scholarly journals Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins

2002 ◽  
Vol 99 (20) ◽  
pp. 12753-12758 ◽  
Author(s):  
D. Yabe ◽  
M. S. Brown ◽  
J. L. Goldstein
Keyword(s):  
Endoplasmic Reticulum ◽  
Binding Proteins ◽  
Regulatory Element ◽  
Endoplasmic Reticulum Protein ◽  
Sterol Regulatory Element

New insights into the activation of sterol regulatory element-binding proteins by proteolytic processing

2013 ◽  
Vol 4 (4) ◽  
pp. 417-423 ◽  
Author(s):  
Jun Inoue ◽  
Ryuichiro Sato
Keyword(s):  
Endoplasmic Reticulum ◽  
Small Molecules ◽  
Recent Progress ◽  
Binding Proteins ◽  
Regulatory Element ◽  
Acid Synthesis ◽  
Proteolytic Processing ◽  
Endoplasmic Reticulum Membrane ◽  
Post Translational Modification ◽  
Sterol Regulatory Element

AbstractSterol regulatory element-binding proteins (SREBPs) are transcription factors that regulate a wide variety of genes involved in cholesterol and fatty acid synthesis. After transcription, SREBPs are controlled at multiple post-transcriptional levels, including proteolytic processing and post-translational modification. Among these, proteolytic processing is a crucial regulatory step that activates SREBPs, which are synthesized as inactive endoplasmic reticulum membrane proteins. In this review, we focus on recent progress with regard to signaling pathways and small molecules that affect activation of SREBPs by proteolytic processing.

PO7-181 DESMOSTEROL CAN REGULATE THE PROCESSING OF THE STEROL REGULATORY ELEMENT BINDING PROTEINS AND THE EXPRESSION OF TARGET GENES

2007 ◽  
Vol 8 (1) ◽  
pp. 62
Author(s):  
S. Rodriguez-Acebes ◽  
J. Martinez-Botas ◽  
A. Davalos ◽  
M.A. Lasuncion ◽  
R.B. Rawson ◽  
...  
Keyword(s):  
Binding Proteins ◽  
Target Genes ◽  
Regulatory Element ◽  
Sterol Regulatory Element

Sterol regulatory element-binding proteins

1999 ◽  
Vol 10 (2) ◽  
pp. 143-150 ◽  
Author(s):  
Jay D. Morton ◽  
Lichiro Shimomura
Keyword(s):  
Binding Proteins ◽  
Regulatory Element ◽  
Sterol Regulatory Element

scholarly journals Soy Isoflavones Affect Sterol Regulatory Element Binding Proteins (SREBPs) and SREBP-Regulated Genes in HepG2 Cells

2004 ◽  
Vol 134 (11) ◽  
pp. 2942-2947 ◽  
Author(s):  
Eimear Mullen ◽  
Rachel M. Brown ◽  
Timothy F. Osborne ◽  
Neil F. Shay
Keyword(s):  
Hepg2 Cells ◽  
Binding Proteins ◽  
Regulatory Element ◽  
Soy Isoflavones ◽  
Sterol Regulatory Element
Sign in / Sign up

Export Citation Format

Share Document