scholarly journals Structure and expression of a mouse major histocompatibility antigen gene, H-2Ld.

1982 ◽  
Vol 79 (6) ◽  
pp. 1994-1998 ◽  
Author(s):  
G. A. Evans ◽  
D. H. Margulies ◽  
R. D. Camerini-Otero ◽  
K. Ozato ◽  
J. G. Seidman
Keyword(s):  
Histocompatibility Antigen ◽  
Major Histocompatibility ◽  
Major Histocompatibility Antigen ◽  
Antigen Gene

Activation of a Qa/Tla class I major histocompatibility antigen gene is a general feature of oncogenesis in the mouse

Nature ◽  
1983 ◽  
Vol 306 (5945) ◽  
pp. 756-760 ◽  
Author(s):  
Paul M. Brickell ◽  
David S. Latchman ◽  
David Murphy ◽  
Keith Willison ◽  
Peter W. J. Rigby
Keyword(s):  
General Feature ◽  
Histocompatibility Antigen ◽  
Class I ◽  
Major Histocompatibility ◽  
Major Histocompatibility Antigen ◽  
Antigen Gene

The class I major histocompatibility antigen gene activated in a line of SV40-transformed mouse cells is H–2Dd, not Qa/Tla

Nature ◽  
1985 ◽  
Vol 316 (6024) ◽  
pp. 162-163 ◽  
Author(s):  
Paul M. Brickell ◽  
David S. Latchman ◽  
David Murphy ◽  
Keith Willison ◽  
Peter W. J. Rigby
Keyword(s):  
Histocompatibility Antigen ◽  
Class I ◽  
Major Histocompatibility ◽  
Major Histocompatibility Antigen ◽  
Antigen Gene ◽  
Mouse Cells

Differential expression of porcine major histocompatibility DNA sequences introduced into mouse L cells

1983 ◽  
Vol 3 (11) ◽  
pp. 2006-2016
Author(s):  
M L Satz ◽  
D S Singer
Keyword(s):  
Dna Sequences ◽  
Genomic Dna ◽  
Histocompatibility Antigen ◽  
Transformed Cells ◽  
Major Histocompatibility ◽  
Major Histocompatibility Antigen ◽  
L Cells ◽  
Foreign Dna ◽  
Differential Transcription ◽  
Major Histocompatibility Gene

The expression of a porcine genomic DNA segment containing a major histocompatibility gene and its chromatin structure in mouse L cells have been investigated. The transformed cells, which contain about two copies of the 17.8-kilobase pig DNA insert per haploid genome, stably and uniformly express major histocompatibility antigen on their surfaces. This expression is the result of differential transcription of the 3-kilobase major histocompatibility gene; the other 14 kilobases of pig sequences flanking the coding sequence are not transcribed. Although the entire pig DNA segment is packaged into nucleosomes, only the transcriptionally active DNA sequences are packaged in a DNase I-sensitive conformation. These results suggest that the expression of this foreign DNA is actively regulated in L cells.

scholarly journals The failure of a major histocompatibility antigen to stimulate a thyroid allograft reaction after culture in oxygen.

1983 ◽  
Vol 157 (3) ◽  
pp. 898-906 ◽  
Author(s):  
F G La Rosa ◽  
D W Talmage
Keyword(s):  
Lymphocytic Infiltration ◽  
Histocompatibility Antigen ◽  
High Variability ◽  
Host Factors ◽  
Striking Difference ◽  
Major Histocompatibility ◽  
Major Histocompatibility Antigen ◽  
Similar Correlation ◽  
Highly Correlated ◽  
A Minor

The lymphocytic infiltration found in multiple cultured BALB/c thyroids placed in the same C57BL/6 recipient was found to be highly correlated and the high variability between animals was not influenced by the number of lobes. It was concluded that the variable infiltration was largely due to host factors. Because a similar correlation was found between BALB/c and C3H grafts, the response to a minor antigen common to these two strains was suggested as a cause of the infiltration. When the response of C57BL/6 mice to cultured B6.C (H-2d) and BALB.B (H-2b) grafts was compared, a synergism between major and minor antigens was suggested. However, when the time of culture was increased from 48 to 60 h and the response of BALB/c and C57BL/6 mice were compared with identically cultured B6.C (H-2d) grafts, a striking difference between major and minor antigens was observed. None of 10 such grafts in C57BL/6 recipients (major antigens only) showed any infiltration, whereas 8 out of the 9 grafts in BALB/c recipients (minor antigens only) were infiltrated.

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