scholarly journals SMRTe, a silencing mediator for retinoid and thyroid hormone receptors-extended isoform that is more related to the nuclear receptor corepressor

1999 ◽  
Vol 96 (7) ◽  
pp. 3519-3524 ◽  
Author(s):  
E.-J. Park ◽  
D. J. Schroen ◽  
M. Yang ◽  
H. Li ◽  
L. Li ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Nuclear Receptor ◽  
Hormone Receptors ◽  
Thyroid Hormone Receptors ◽  
Nuclear Receptor Corepressor

scholarly journals The Book of Opposites: The Role of the Nuclear Receptor Co-regulators in the Suppression of Epidermal Genes by Retinoic Acid and Thyroid Hormone Receptors

2005 ◽  
Vol 124 (5) ◽  
pp. 1034-1043 ◽  
Author(s):  
Sang H. Jho ◽  
Constantinos Vouthounis ◽  
Brian Lee ◽  
Olivera Stojadinovic ◽  
Mark J. Im ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Thyroid Hormone ◽  
Nuclear Receptor ◽  
Hormone Receptors ◽  
Thyroid Hormone Receptors

scholarly journals The p160 Coactivator PAS-B Motif Stabilizes Nuclear Receptor Binding and Contributes to Isoform-specific Regulation by Thyroid Hormone Receptors

2009 ◽  
Vol 284 (29) ◽  
pp. 19554-19563 ◽  
Author(s):  
Martin L. Privalsky ◽  
Sangho Lee ◽  
Johnnie B. Hahm ◽  
Briana M. Young ◽  
Rebecca N. G. Fong ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Nuclear Receptor ◽  
Receptor Binding ◽  
Hormone Receptors ◽  
Thyroid Hormone Receptors ◽  
Specific Regulation

scholarly journals Transducin β-like 1, X-linked and nuclear receptor co-repressor cooperatively augment the ligand-independent stimulation of TRH and TSHβ gene promoters by thyroid hormone receptors

2018 ◽  
Vol 65 (8) ◽  
pp. 805-813 ◽  
Author(s):  
Tetsuya Takamizawa ◽  
Tetsurou Satoh ◽  
Tomoko Miyamoto ◽  
Yasuyo Nakajima ◽  
Takahiro Ishizuka ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Nuclear Receptor ◽  
Hormone Receptors ◽  
Thyroid Hormone Receptors ◽  
Gene Promoters ◽  
Stimulation Of

scholarly journals Nuclear Receptor Corepressor Recruitment by Unliganded Thyroid Hormone Receptor in Gene Repression during Xenopus laevis Development

2002 ◽  
Vol 22 (24) ◽  
pp. 8527-8538 ◽  
Author(s):  
Laurent M. Sachs ◽  
Peter L. Jones ◽  
Emmanuelle Havis ◽  
Nicole Rouse ◽  
Barbara A. Demeneix ◽  
...  
Keyword(s):  
Gene Expression ◽  
Thyroid Hormone ◽  
Xenopus Laevis ◽  
Nuclear Receptor ◽  
Molecular Mechanisms ◽  
Hormone Receptors ◽  
Thyroid Hormone Receptor ◽  
Dominant Negative ◽  
Gene Repression ◽  
Nuclear Receptor Corepressor

ABSTRACT Thyroid hormone receptors (TR) act as activators of transcription in the presence of the thyroid hormone (T3) and as repressors in its absence. While many in vitro approaches have been used to study the molecular mechanisms of TR action, their physiological relevance has not been addressed. Here we investigate how TR regulates gene expression during vertebrate postembryonic development by using T3-dependent amphibian metamorphosis as a model. Earlier studies suggest that TR acts as a repressor during premetamorphosis when T3 is absent. We hypothesize that corepressor complexes containing the nuclear receptor corepressor (N-CoR) are key factors in this TR-dependent gene repression, which is important for premetamorphic tadpole growth. To test this hypothesis, we isolated Xenopus laevis N-CoR (xN-CoR) and showed that it was present in pre- and metamorphic tadpoles. Using a chromatin immunoprecipitation assay, we demonstrated that xN-CoR was recruited to the promoters of T3 response genes during premetamorphosis and released upon T3 treatment, accompanied by a local increase in histone acetylation. Furthermore, overexpression of a dominant-negative N-CoR in tadpole tail muscle led to increased transcription from a T3-dependent promoter. Our data indicate that N-CoR is recruited by unliganded TR to repress target gene expression during premetamorphic animal growth, an important process that prepares the tadpole for metamorphosis.

International Union of Pharmacology. LIX. The Pharmacology and Classification of the Nuclear Receptor Superfamily: Thyroid Hormone Receptors

2006 ◽  
Vol 58 (4) ◽  
pp. 705-711 ◽  
Author(s):  
Frédéric Flamant ◽  
John D. Baxter ◽  
Douglas Forrest ◽  
Samuel Refetoff ◽  
Herbert Samuels ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Nuclear Receptor ◽  
Hormone Receptors ◽  
Thyroid Hormone Receptors ◽  
International Union ◽  
Nuclear Receptor Superfamily
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