scholarly journals Transducin β-like 1, X-linked and nuclear receptor co-repressor cooperatively augment the ligand-independent stimulation of TRH and TSHβ gene promoters by thyroid hormone receptors

2018 ◽  
Vol 65 (8) ◽  
pp. 805-813 ◽  
Author(s):  
Tetsuya Takamizawa ◽  
Tetsurou Satoh ◽  
Tomoko Miyamoto ◽  
Yasuyo Nakajima ◽  
Takahiro Ishizuka ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Nuclear Receptor ◽  
Hormone Receptors ◽  
Thyroid Hormone Receptors ◽  
Gene Promoters ◽  
Stimulation Of

scholarly journals The Book of Opposites: The Role of the Nuclear Receptor Co-regulators in the Suppression of Epidermal Genes by Retinoic Acid and Thyroid Hormone Receptors

2005 ◽  
Vol 124 (5) ◽  
pp. 1034-1043 ◽  
Author(s):  
Sang H. Jho ◽  
Constantinos Vouthounis ◽  
Brian Lee ◽  
Olivera Stojadinovic ◽  
Mark J. Im ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Thyroid Hormone ◽  
Nuclear Receptor ◽  
Hormone Receptors ◽  
Thyroid Hormone Receptors

scholarly journals The p160 Coactivator PAS-B Motif Stabilizes Nuclear Receptor Binding and Contributes to Isoform-specific Regulation by Thyroid Hormone Receptors

2009 ◽  
Vol 284 (29) ◽  
pp. 19554-19563 ◽  
Author(s):  
Martin L. Privalsky ◽  
Sangho Lee ◽  
Johnnie B. Hahm ◽  
Briana M. Young ◽  
Rebecca N. G. Fong ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Nuclear Receptor ◽  
Receptor Binding ◽  
Hormone Receptors ◽  
Thyroid Hormone Receptors ◽  
Specific Regulation

Thyroid hormone receptors and stimulation of angiotensinogen production in HepG2 cells

1991 ◽  
Vol 27 (1) ◽  
pp. 21-24 ◽  
Author(s):  
Ian A. Darby ◽  
Jacob Bouhnik ◽  
Ericque D. Coezy ◽  
Pierre Corvol
Keyword(s):  
Thyroid Hormone ◽  
Hepg2 Cells ◽  
Hormone Receptors ◽  
Thyroid Hormone Receptors ◽  
Stimulation Of

Differential binding of thyroid hormone receptors to mouse glandular kallikrein gene promoters: evidence for multiple binding regions in the mGK-6 gene

1989 ◽  
Vol 3 (2) ◽  
pp. 79-84 ◽  
Author(s):  
J. W. Barlow ◽  
L. E. Raggatt ◽  
C. C. Drinkwater ◽  
I. G. Lyons ◽  
R. I. Richards
Keyword(s):  
Thyroid Hormone ◽  
Promoter Region ◽  
Hormone Receptors ◽  
Thyroid Hormone Receptor ◽  
Thyroid Hormone Receptors ◽  
Gene Promoters ◽  
Glandular Kallikrein ◽  
Gh Gene ◽  
Preferential Binding ◽  
Cloned Gene

ABSTRACT We have used a DNA-cellulose competition assay to investigate the binding of thyroid hormone receptors to fragments of the mouse glandular kallikrein genes and the human and rat GH genes. Nuclear extracts from human lymphoblastoid IM-9 cells were incubated with [125I]tri-iodothyronine ([125I]T3) and DNA-cellulose. The ability of cloned gene fragments to compete for radiolabelled receptors bound to DNA-cellulose was compared with that of DNA from pBR322. As previously observed, a 900 bp fragment from the human GH gene showed preferential binding to the thyroid hormone receptor. High-affinity binding was observed with a synthetic fragment of the rat GH gene encompassing positions − 163 to − 192 but not with a similar fragment from positions −224 to −192. Preferential binding was also observed with fragments of the mouse glandular kallikrein gene, mGK-6. Binding to the entire gene and fragments containing 2300 and 776 bp of the promoter region was identical. Detectable but reduced binding was seen with a shorter fragment. These results suggest that the T3 receptor binds to multiple sites within the first 776 bp of the mGK-6 gene promoter. Potential thyroid hormone response elements can be identified within this region of the gene. In contrast, the kallikrein gene mGK-3, which shows a different response to thyroid hormone from that of mGK-6, showed no significant binding in the comparable promoter region.

International Union of Pharmacology. LIX. The Pharmacology and Classification of the Nuclear Receptor Superfamily: Thyroid Hormone Receptors

2006 ◽  
Vol 58 (4) ◽  
pp. 705-711 ◽  
Author(s):  
Frédéric Flamant ◽  
John D. Baxter ◽  
Douglas Forrest ◽  
Samuel Refetoff ◽  
Herbert Samuels ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Nuclear Receptor ◽  
Hormone Receptors ◽  
Thyroid Hormone Receptors ◽  
International Union ◽  
Nuclear Receptor Superfamily
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