scholarly journals A Cytoplasmic Tyrosine Is Essential for the Basolateral Localization of Mutants of the Human Nerve Growth Factor Receptor in Madin- Darby Canine Kidney Cells

1995 ◽  
Vol 270 (20) ◽  
pp. 12219-12225 ◽  
Author(s):  
Laure Monlauzeur ◽  
Ayyapan Rajasekaran ◽  
Moses Chao ◽  
Enrique Rodriguez-Boulan ◽  
André Le Bivic
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Growth Factor Receptor ◽  
Nerve Growth Factor Receptor ◽  
Kidney Cells ◽  
Madin Darby Canine Kidney ◽  
Nerve Growth ◽  
Human Nerve ◽  
Darby Canine Kidney ◽  
Canine Kidney

mLin-7 is localized to the basolateral surface of renal epithelia via its NH2 terminus

2000 ◽  
Vol 278 (3) ◽  
pp. F464-F475 ◽  
Author(s):  
Samuel W. Straight ◽  
David Karnak ◽  
Jean-Paul Borg ◽  
Emmanuel Kamberov ◽  
Heidi Dare ◽  
...  
Keyword(s):  
Amino Acids ◽  
Growth Factor ◽  
Receptor Tyrosine Kinase ◽  
Growth Factor Receptor ◽  
Kidney Cells ◽  
Madin Darby Canine Kidney ◽  
Renal Epithelia ◽  
Renal Epithelial Cells ◽  
Darby Canine Kidney ◽  
Canine Kidney

In Caenorhabditis elegans, the basolateral localization of the Let-23 growth factor receptor tyrosine kinase requires the expression of three genes: lin-2, lin-7, and lin-10. Mammalian homologs of these three genes have been identified, and a complex of their protein products exists in mammalian neurons. In this paper, we examine the interaction of these mammalian proteins in renal epithelia. Coprecipitation experiments demonstrated that mLin-2/CASK binds to mLin-7, and immunofluorescent labeling showed that these proteins colocalized at the basolateral surface of Madin-Darby canine kidney cells and renal epithelia. Although labeling intensity varied markedly among different renal epithelial cells, those cells strongly expressing mLin-7 also showed intense mLin-2/CASK labeling. We have also demonstrated that mLin-2/CASK binding requires amino acids 12–32 of mLin-7 and have shown that this region of mLin-7 is also necessary for the targeting of mLin-7 to the basolateral surface. Furthermore, the overexpression of mLin-2/CASK mutants in Madin-Darby canine kidney cells caused endogenous mLin-7 to mislocalize. In summary, the NH2 terminus of mLin-7 is crucial for its basolateral localization, likely through its interaction with mLin-2/CASK.

Zhangfei, a novel regulator of the human nerve growth factor receptor, trkA

2008 ◽  
Vol 14 (5) ◽  
pp. 425-436 ◽  
Author(s):  
Ximena Valderrama ◽  
Ximena Valderrama ◽  
Noreen Rapin ◽  
Vikram Misra
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Growth Factor Receptor ◽  
Nerve Growth Factor Receptor ◽  
Nerve Growth ◽  
Human Nerve

Transient expression of full-length and truncated forms of the human nerve growth factor receptor

1990 ◽  
Vol 8 (2) ◽  
pp. 137-141 ◽  
Author(s):  
Usha Rani Reddy ◽  
Gita Venkatakrishnan ◽  
Gerd G. Maul ◽  
Amit K. Roy ◽  
Alonzo H. Ross
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Transient Expression ◽  
Growth Factor Receptor ◽  
Nerve Growth Factor Receptor ◽  
Full Length ◽  
Nerve Growth ◽  
Human Nerve

Expression of human nerve growth factor receptor on cells derived from all three germ layers

1988 ◽  
Vol 174 (2) ◽  
pp. 533-539 ◽  
Author(s):  
Timothy M. Thomson ◽  
Wolfgang J. Rettig ◽  
Pilar Garin Chesa ◽  
Steven H. Green ◽  
Alfredo Carrato Mena ◽  
...  
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Growth Factor Receptor ◽  
Nerve Growth Factor Receptor ◽  
Germ Layers ◽  
Nerve Growth ◽  
Human Nerve

P75 Nerve Growth Factor Receptor Is Expressed in Regenerating Human Nerve Grafts

2008 ◽  
Vol 146 (2) ◽  
pp. 254-261 ◽  
Author(s):  
Tuija M. Ylä-Kotola ◽  
M. Susanna C. Kauhanen ◽  
Sirpa L. Asko-Seljavaara ◽  
Caj H. Haglund ◽  
Erkki Tukiainen ◽  
...  
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Growth Factor Receptor ◽  
Nerve Growth Factor Receptor ◽  
Nerve Growth ◽  
Nerve Grafts ◽  
Human Nerve
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