scholarly journals Differential Intrinsic Enzymatic Activity of Syk and Zap-70 Protein-tyrosine Kinases

1996 ◽  
Vol 271 (37) ◽  
pp. 22782-22790 ◽  
Author(s):  
Sylvain Latour ◽  
Lionel M. L. Chow ◽  
André Veillette
Keyword(s):  
Enzymatic Activity ◽  
Tyrosine Kinases ◽  
Protein Tyrosine Kinases ◽  
Protein Tyrosine

scholarly journals Functional interrogation and therapeutic targeting of protein tyrosine phosphatases

2021 ◽  
Author(s):  
Aaron D. Krabill ◽  
Zhong-Yin Zhang
Keyword(s):  
Enzymatic Activity ◽  
Tyrosine Kinases ◽  
Drug Target ◽  
Protein Tyrosine Phosphatases ◽  
Protein Tyrosine Kinases ◽  
Protein Tyrosine Phosphorylation ◽  
Tyrosine Phosphatases ◽  
Therapeutic Targeting ◽  
Protein Tyrosine ◽  
Disease States

Protein tyrosine phosphatases (PTPs) counteract the enzymatic activity of protein tyrosine kinases to modulate levels of both normal and disease-associated protein tyrosine phosphorylation. Aberrant activity of PTPs has been linked to the progression of many disease states, yet no PTP inhibitors are currently clinically available. PTPs are without a doubt a difficult drug target. Despite this, many selective, potent, and bioavailable PTP inhibitors have been described, suggesting PTPs should once again be looked at as viable therapeutic targets. Herein, we summarize recently discovered PTP inhibitors and their use in the functional interrogation of PTPs in disease states. In addition, an overview of the therapeutic targeting of PTPs is described using SHP2 as a representative target.

Naturally Occurring Homoisoflavonoids as Potent Protein Tyrosine Kinases Inhibitors

Planta Medica ◽  
2008 ◽  
Vol 74 (03) ◽  
Author(s):  
Y Ye ◽  
LG Lin ◽  
H Xie ◽  
HL Li ◽  
HL Jiang ◽  
...  
Keyword(s):  
Tyrosine Kinases ◽  
Protein Tyrosine Kinases ◽  
Protein Tyrosine ◽  
Naturally Occurring

Differential Effects of Somatostatin and Its Analog on Protein Tyrosine Kinases Activity in the Rat Pituitary and the Murine Colonic Tumors

1998 ◽  
Vol 246 (2) ◽  
pp. 375-377 ◽  
Author(s):  
Marek Pawlikowski ◽  
Lilla Lachowicz ◽  
Jolanta Kunert-Radek ◽  
Katarzyna Winczyk ◽  
Grażyna Janiszewska ◽  
...  
Keyword(s):  
Tyrosine Kinases ◽  
Protein Tyrosine Kinases ◽  
Differential Effects ◽  
Protein Tyrosine ◽  
Rat Pituitary

Structure-Based Design of a Potent, Selective, and Irreversible Inhibitor of the Catalytic Domain of the erbB Receptor Subfamily of Protein Tyrosine Kinases

1997 ◽  
Vol 40 (7) ◽  
pp. 1130-1135 ◽  
Author(s):  
Juswinder Singh ◽  
Ellen M. Dobrusin ◽  
David W. Fry ◽  
Taraneh Haske ◽  
Adrian Whitty ◽  
...  
Keyword(s):  
Tyrosine Kinases ◽  
Catalytic Domain ◽  
Protein Tyrosine Kinases ◽  
Erbb Receptor ◽  
Irreversible Inhibitor ◽  
Protein Tyrosine
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