scholarly journals Extracellular Cleavage of the Vascular Endothelial Growth Factor 189-Amino Acid Form by Urokinase Is Required for Its Mitogenic Effect

1997 ◽  
Vol 272 (20) ◽  
pp. 13390-13396 ◽  
Author(s):  
Jean Plouët ◽  
Francoise Moro ◽  
Stéphane Bertagnolli ◽  
Nadine Coldeboeuf ◽  
Honore Mazarguil ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Amino Acid ◽  
Growth Factor ◽  
Vascular Endothelial ◽  
Acid Form ◽  
Mitogenic Effect ◽  
Amino Acid Form ◽  
Endothelial Growth Factor

scholarly journals 2′-Fluoropyrimidine RNA-based Aptamers to the 165-Amino Acid Form of Vascular Endothelial Growth Factor (VEGF165)

1998 ◽  
Vol 273 (32) ◽  
pp. 20556-20567 ◽  
Author(s):  
Judy Ruckman ◽  
Louis S. Green ◽  
Jim Beeson ◽  
Sheela Waugh ◽  
Wendy L. Gillette ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Amino Acid ◽  
Growth Factor ◽  
Vascular Endothelial ◽  
Acid Form ◽  
Amino Acid Form ◽  
Endothelial Growth Factor

A nonsense variation p.Arg325X in the vascular endothelial growth factor-A gene may be associated with congenital tricuspid aortic valve stenosis

2011 ◽  
Vol 22 (3) ◽  
pp. 316-322 ◽  
Author(s):  
Wu Zhao ◽  
Jian Wang ◽  
Jie Shen ◽  
Kun Sun ◽  
Yiwei Chen ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Amino Acid ◽  
Growth Factor ◽  
Aortic Valve ◽  
Aortic Valve Stenosis ◽  
Stop Codon ◽  
Vascular Endothelial ◽  
Tricuspid Aortic Valve ◽  
Cardiac Phenotype ◽  
Endothelial Growth Factor

AbstractBackgroundIn our recent study, we first reported that mutation in vascular endothelial growth factor-A is associated with bicuspid aortic valve stenosis. However, to date no groups have explored the role of vascular endothelial growth factor-A variations in the aetiology of congenital tricuspid aortic valve stenosis.MethodsWe sequenced all eight coding exons and exon–intron boundaries of the vascular endothelial growth factor-A gene in deoxyribonucleic acid samples of a cohort of 32 sporadic patients with tricuspid aortic valve stenosis, 300 normal controls, and 103 disease controls – conotruncal defects – in order to identify sequence variants.ResultsWe identified a c.973C > T heterozygous nonsense variation in exon 6 of the vascular endothelial growth factor-A gene in a patient with an isolated tricuspid aortic valve stenosis. The c.973C > T variation, which was absent in all controls, changes a highly conserved arginine at amino acid position 325 to a stop codon (p.Arg325X) and is predicted to produce a truncated protein of 324 amino acid residues. The proband's parents had a normal cardiac phenotype; however, his father was a carrier of the p.Arg325X variation, which indicates that the p.Arg325X variation is inherited and incompletely penetrant.ConclusionWe report for the first time that the p.Arg325X nonsense variation in the vascular endothelial growth factor-A gene may be associated with congenital tricuspid aortic valve stenosis.

scholarly journals Prokineticin receptors (version 2020.4) in the IUPHAR/BPS Guide to Pharmacology Database

2020 ◽  
Vol 2020 (4) ◽  
Author(s):  
Rebecca Hills ◽  
Adam J. Pawson ◽  
Philippe Rondard ◽  
Oualid Sbai ◽  
Qun-Yong Zhou
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Amino Acid ◽  
Growth Factor ◽  
Endocrine Gland ◽  
Vascular Endothelial ◽  
High Potency ◽  
Prokineticin 2 ◽  
Selective Agonist ◽  
Macrophage Chemotaxis ◽  
Endothelial Growth Factor

Prokineticin receptors, PKR1 and PKR2 (provisional nomenclature as recommended by NC-IUPHAR [23]) respond to the cysteine-rich 81-86 amino-acid peptides prokineticin-1 (also known as endocrine gland-derived vascular endothelial growth factor, mambakine) and prokineticin-2 (protein Bv8 homologue). An orthologue of PROK1 from black mamba (Dendroaspis polylepis) venom, mamba intestinal toxin 1 (MIT1, [65]) is a potent, non-selective agonist at prokineticin receptors [41], while Bv8, an orthologue of PROK2 from amphibians (Bombina sp., [44]), is equipotent at recombinant PKR1 and PKR2 [48], and has high potency in macrophage chemotaxis assays, which are lost in PKR1-null mice.

scholarly journals Prokineticin receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

2019 ◽  
Vol 2019 (4) ◽  
Author(s):  
Rebecca Hills ◽  
Philippe Rondard ◽  
Oualid Sbai ◽  
Qun-Yong Zhou
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Amino Acid ◽  
Growth Factor ◽  
Endocrine Gland ◽  
Vascular Endothelial ◽  
High Potency ◽  
Prokineticin 2 ◽  
Selective Agonist ◽  
Macrophage Chemotaxis ◽  
Endothelial Growth Factor

Prokineticin receptors, PKR1 and PKR2 (provisional nomenclature as recommended by NC-IUPHAR [23]) respond to the cysteine-rich 81-86 amino-acid peptides prokineticin-1 (also known as endocrine gland-derived vascular endothelial growth factor, mambakine) and prokineticin-2 (protein Bv8 homologue). An orthologue of PROK1 from black mamba (Dendroaspis polylepis) venom, mamba intestinal toxin 1 (MIT1, [65]) is a potent, non-selective agonist at prokineticin receptors [41], while Bv8, an orthologue of PROK2 from amphibians (Bombina sp., [44]), is equipotent at recombinant PKR1 and PKR2 [48], and has high potency in macrophage chemotaxis assays, which are lost in PKR1-null mice.

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