scholarly journals Interaction of Heparan Sulfate from Mammary Cells with Acidic Fibroblast Growth Factor (FGF) and Basic FGF

1998 ◽  
Vol 273 (13) ◽  
pp. 7303-7310 ◽  
Author(s):  
Hassan Rahmoune ◽  
Hai-Lan Chen ◽  
John T. Gallagher ◽  
Philip S. Rudland ◽  
David G. Fernig
Keyword(s):  
Growth Factor ◽  
Heparan Sulfate ◽  
Fibroblast Growth Factor ◽  
Mammary Cells ◽  
Fibroblast Growth ◽  
Acidic Fibroblast Growth Factor ◽  
Basic Fgf

Extracellular matrix heparan sulfate proteoglycans modulate the mitogenic capacity of acidic fibroblast growth factor

1989 ◽  
Vol 140 (3) ◽  
pp. 584-592 ◽  
Author(s):  
Portia B. Gordon ◽  
Haing U. Choi ◽  
Greg Conn ◽  
Asra Ahmed ◽  
Bettina Ehrmann ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Growth Factor ◽  
Heparan Sulfate ◽  
Fibroblast Growth Factor ◽  
Heparan Sulfate Proteoglycans ◽  
Fibroblast Growth ◽  
Acidic Fibroblast Growth Factor

Acidic fibroblast growth factor (FGF) but not basic FGF induces sleep and fever in rabbits

1995 ◽  
Vol 269 (1) ◽  
pp. R87-R91 ◽  
Author(s):  
M. Knefati ◽  
C. Somogyi ◽  
L. Kapas ◽  
T. Bourcier ◽  
J. M. Krueger
Keyword(s):  
Growth Factor ◽  
Dna Synthesis ◽  
Fibroblast Growth Factor ◽  
Brain Temperature ◽  
Interleukin 1 ◽  
Fibroblast Growth ◽  
Sleep Regulation ◽  
Acidic Fibroblast Growth Factor ◽  
Basic Fgf ◽  
Functional Features

Acidic fibroblast growth factor (FGF) and basic FGF belong to a growth factor family. Interleukin-1, another member of that family, is involved in sleep regulation. FGFs and interleukin-1 share structural and functional features. We therefore determined whether acidic FGF and basic FGF were somnogenic. Male New Zealand White rabbits were provided with electroencephalographic (EEG) electrodes, a brain thermistor, and a lateral intracerebroventricular (icv) cannula. The animals were injected icv with isotonic NaCl (control) and on separate days with one of three doses of acidic or basic FGF (0.01, 0.1, or 1.0 micrograms) or with heat-treated acidic FGF (1.0 micrograms). The EEG, brain temperature, and motor activity were recorded for 23 h. The biological activity of basic FGF was determined in vitro by its ability to induce DNA synthesis in rat aortic smooth muscle cells. Acidic FGF induced prolonged dose-related increases in non-rapid eye movement sleep beginning in the 1st postinjection h and continuing for 12-23 h after the treatment. Acidic FGF also induced fevers of approximately 1 degree C after the 1.0 micrograms dose. Both activities of acidic FGF were lost after heat treatment. In contrast, basic FGF lacked somnogenic and pyrogenic activity, although it did induce DNA synthesis. Current results suggest that acidic FGF is part of the complex cytokine network in brain involved in sleep regulation.

scholarly journals Purification of Acidic Fibroblast Growth Factor from Bovine Heart and Its Localization in the Cardiac Myocytes

1989 ◽  
Vol 264 (29) ◽  
pp. 17606-17612
Author(s):  
H Sasaki ◽  
H Hoshi ◽  
Y M Hong ◽  
T Suzuki ◽  
T Kato ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Cardiac Myocytes ◽  
Fibroblast Growth ◽  
Acidic Fibroblast Growth Factor ◽  
Bovine Heart

Interaction of Fibroblast Growth Factor-1 and Related Peptides with Heparan Sulfate and Its Oligosaccharides

1997 ◽  
Vol 346 (2) ◽  
pp. 252-262 ◽  
Author(s):  
Jonathan R. Fromm ◽  
Ronald E. Hileman ◽  
John M. Weiler ◽  
Robert J. Linhardt
Keyword(s):  
Growth Factor ◽  
Heparan Sulfate ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth
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