scholarly journals The Major Core Protein of Messenger Ribonucleoprotein Particles (p50) Promotes Initiation of Protein Biosynthesisin Vitro

1998 ◽  
Vol 273 (6) ◽  
pp. 3574-3581 ◽  
Author(s):  
Valentina M. Evdokimova ◽  
Elizaveta A. Kovrigina ◽  
Dmitry V. Nashchekin ◽  
Elena K. Davydova ◽  
John W. B. Hershey ◽  
...  
Keyword(s):  
Core Protein ◽  
Ribonucleoprotein Particles ◽  
Messenger Ribonucleoprotein ◽  
Major Core Protein

Expression of maedi-visna virus major core protein, p25: development of a sensitive p25 antigen detection assay

1992 ◽  
Vol 37 (3) ◽  
pp. 305-320 ◽  
Author(s):  
H.T. Reyburn ◽  
D.J. Roy ◽  
B.A. Blacklaws ◽  
D.R. Sargan ◽  
I. McConnell
Keyword(s):  
Core Protein ◽  
Antigen Detection ◽  
Visna Virus ◽  
Detection Assay ◽  
Maedi Visna Virus ◽  
Major Core Protein

scholarly journals In Silico Studies on Development of Novel Virostatic Agents against Bluetongue Virus

ISRN Virology ◽  
2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Pandrangi Anupama
Keyword(s):  
Bluetongue Virus ◽  
Core Protein ◽  
Critical Role ◽  
Docking Studies ◽  
Site Specific ◽  
The Core ◽  
In Silico Studies ◽  
Vp7 Protein ◽  
Major Core Protein

The core of BTV is organized into three concentric structures of which VP7 protein forms the major core protein. The subcore consists of VP3 protein and the innermost part of the core is made of three minor proteins: VP1, VP4, and VP6. Earlier it was reported that core-like particles (CLPs) composed of viral VP7 and VP3 proteins were produced in order to study role of VP7 protein in intermolecular interactions in the BTV assembly process. Site specific mutational studies revealed that substitution of the single lysine residue of VP7 (Lys-255) by leucine abrogated CLP formation, indicating a critical role for this lysine. In the present study, homology modeling, mutagenesis, and docking studies were carried out in order to design potent leads in modulation of VP7 protein in abrogating CLP formation.

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