scholarly journals Roles of the C Termini of α-, β-, and γ-Subunits of Epithelial Na+Channels (ENaC) in Regulating ENaC and Mediating Its Inhibition by Cytosolic Na+

2001 ◽  
Vol 276 (17) ◽  
pp. 13744-13749 ◽  
Author(s):  
Anuwat Dinudom ◽  
Kieran F. Harvey ◽  
Permsak Komwatana ◽  
Corina N. Jolliffe ◽  
John A. Young ◽  
...  
1997 ◽  
Vol 272 (3) ◽  
pp. L407-L412 ◽  
Author(s):  
G. Yue ◽  
S. Matalon

We instilled 4 ml isotonic fluid containing trace amounts of fluorescently labeled dextran (molecular mass 150 kDa) in the lungs of rats exposed to either 85% O(2) for 7 days or to 85% O(2) for 7 days and 100% O(2) for 3 days. We withdrew the fluid every hour for a 3-h period and calculated alveolar fluid clearance (AFC) from changes in dextran concentration. Postinstillation (3 h), AFC values in the control and the two hyperoxic groups were 51 +/- 1, 63 +/- 2, and 62 +/- 3 (SE), respectively (%instilled volume; n > or = 5; P < 0.05). Addition of either 1 mM amiloride or N-ethyl-N-isopropyl amiloride (EIPA) in the instillate decreased the AFC values in all groups 3 h later to approximately 30% of instilled volume. Instillation of phenamil, an irreversible blocker of epithelial Na+ channels into the lungs of rats exposed to 85% O(2) for 7 days and 100% O(2) for 2 days, resulted in a significant increase of their extravascular lung fluid volumes 24 h later. These results demonstrate the existence of EIPA-inhibitable Na+ channels in alveolar epithelial cells in vivo and indicate that an increase in Na+ transport plays an important role in limiting the amount of alveolar edema in O(2)-damaged lungs.


2004 ◽  
Vol 280 (9) ◽  
pp. 8513-8522 ◽  
Author(s):  
Shaohu Sheng ◽  
Clint J. Perry ◽  
Ossama B. Kashlan ◽  
Thomas R. Kleyman

1996 ◽  
Vol 432 (5) ◽  
pp. 760-766 ◽  
Author(s):  
A. E. Busch ◽  
H. Suessbrich ◽  
K. Kunzelmann ◽  
A. Hipper ◽  
R. Greger ◽  
...  

2018 ◽  
Vol 596 (16) ◽  
pp. 3585-3602 ◽  
Author(s):  
Gustavo Frindt ◽  
Lei Yang ◽  
Krister Bamberg ◽  
Lawrence G. Palmer

Physiology ◽  
1995 ◽  
Vol 10 (2) ◽  
pp. 61-67 ◽  
Author(s):  
LG Palmer

Epithelial Na channels help maintain Na homeostasis by controlling the rate of Na absorption by the kidney and other organs. Surprisingly, they show homology with genes involved in mechanical sensing and transduction. This suggests that epithelial Na channels and stretch-activated channels may be in the same family.


1985 ◽  
Vol 86 (1) ◽  
pp. 69-77 ◽  
Author(s):  
Kathy Lazorick ◽  
Christopher Miller ◽  
Sarah Sariban-Sohraby ◽  
Dale Benos

1999 ◽  
Vol 274 (53) ◽  
pp. 37693-37704 ◽  
Author(s):  
Hong-Long Ji ◽  
Catherine M. Fuller ◽  
Dale J. Benos

2004 ◽  
Vol 279 (30) ◽  
pp. 31687-31696 ◽  
Author(s):  
Shaohu Sheng ◽  
Clint J. Perry ◽  
Thomas R. Kleyman

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