scholarly journals Functional Role of Fatty Acyl-Coenzyme A Synthetase in the Transmembrane Movement and Activation of Exogenous Long-chain Fatty Acids

2002 ◽  
Vol 277 (33) ◽  
pp. 29369-29376 ◽  
Author(s):  
James D. Weimar ◽  
Concetta C. DiRusso ◽  
Raymond Delio ◽  
Paul N. Black
Keyword(s):  
Fatty Acids ◽  
Functional Role ◽  
Coenzyme A ◽  
Fatty Acyl ◽  
Long Chain Fatty Acids ◽  
Acyl Coenzyme A ◽  
Long Chain ◽  
Chain Fatty Acids

scholarly journals The Inflammatory Response in Acyl-CoA Oxidase 1 Deficiency (Pseudoneonatal Adrenoleukodystrophy)

Endocrinology ◽  
2012 ◽  
Vol 153 (6) ◽  
pp. 2568-2575 ◽  
Author(s):  
H. I. El Hajj ◽  
A. Vluggens ◽  
P. Andreoletti ◽  
K. Ragot ◽  
S. Mandard ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Inflammatory Process ◽  
Kinase Inhibitors ◽  
Coenzyme A ◽  
Human Fibroblasts ◽  
Long Chain Fatty Acids ◽  
Inflammatory Status ◽  
Acyl Coenzyme A ◽  
Long Chain ◽  
Chain Fatty Acids

Among several peroxisomal neurodegenerative disorders, the pseudoneonatal adrenoleukodystrophy (P-NALD) is characterized by the acyl-coenzyme A oxidase 1 (ACOX1) deficiency, which leads to the accumulation of very-long-chain fatty acids (VLCFA) and inflammatory demyelination. However, the components of this inflammatory process in P-NALD remain elusive. In this study, we used transcriptomic profiling and PCR array analyses to explore inflammatory gene expression in patient fibroblasts. Our results show the activation of IL-1 inflammatory pathway accompanied by the increased secretion of two IL-1 target genes, IL-6 and IL-8 cytokines. Human fibroblasts exposed to very-long-chain fatty acids exhibited increased mRNA expression of IL-1α and IL-1β cytokines. Furthermore, expression of IL-6 and IL-8 cytokines in patient fibroblasts was down-regulated by MAPK, p38MAPK, and Jun N-terminal kinase inhibitors. Thus, the absence of acyl-coenzyme A oxidase 1 activity in P-NALD fibroblasts triggers an inflammatory process, in which the IL-1 pathway seems to be central. The use of specific kinase inhibitors may permit the modulation of the enhanced inflammatory status.

scholarly journals The Role of Long-Chain Fatty Acids in Inflammatory Bowel Disease

2019 ◽  
Vol 2019 ◽  
pp. 1-10 ◽  
Author(s):  
Chunxiang Ma ◽  
Reshma Vasu ◽  
Hu Zhang
Keyword(s):  
Inflammatory Bowel Disease ◽  
Fatty Acids ◽  
Bowel Disease ◽  
Mucosal Healing ◽  
Long Chain Fatty Acids ◽  
Inflammatory Bowel ◽  
Underlying Mechanisms ◽  
Long Chain ◽  
Chain Fatty Acids

Inflammatory bowel disease (IBD) is a complicated disease involving multiple pathogenic factors. The complex relationships between long-chain fatty acids (LCFAs) and the morbidity of IBD drive numerous studies to unravel the underlying mechanisms. A better understanding of the role of LCFAs in IBD will substitute or boost the current IBD therapies, thereby obtaining mucosal healing. In this review, we focused on the roles of LCFAs on the important links of inflammatory regulation in IBD, including in the pathogen recognition phase and in the inflammatory resolving phase, and the effects of LCFAs on immune cells in IBD.

scholarly journals Role of Stargardt-3 macular dystrophy protein (ELOVL4) in the biosynthesis of very long chain fatty acids

2008 ◽  
Vol 105 (35) ◽  
pp. 12843-12848 ◽  
Author(s):  
M.-P. Agbaga ◽  
R. S. Brush ◽  
M. N. A. Mandal ◽  
K. Henry ◽  
M. H. Elliott ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Macular Dystrophy ◽  
Long Chain Fatty Acids ◽  
Long Chain ◽  
Chain Fatty Acids

scholarly journals Molecular mechanisms of long-chain fatty acids absorption

2018 ◽  
Vol 9 (3) ◽  
pp. 29-36
Author(s):  
A. Kh. Kade ◽  
A. I. Trofimenko ◽  
P. P. Polyakov ◽  
L. R. Gusaruk ◽  
O. P. Ishevskaia ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Molecular Mechanisms ◽  
Brush Border Membrane ◽  
Web Of Science ◽  
Lipid Binding ◽  
Long Chain Fatty Acids ◽  
Lipid Binding Proteins ◽  
Long Chain ◽  
Chain Fatty Acids

The article presents about the role of several lipid-binding proteins expressed by the small intestine brush border membrane in the main steps of intestinal absorption of long-chain fatty acids and about changes in lipid profile caused by failed absorbtion. The system literature search is performed on Scopus databases, Web of Science, MedLine.

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