scholarly journals Structural Basis for Modulation of Gating Property of G Protein-gated Inwardly Rectifying Potassium Ion Channel (GIRK) by i/o-family G Protein α Subunit (Gαi/o)

2012 ◽  
Vol 287 (23) ◽  
pp. 19537-19549 ◽  
Author(s):  
Yoko Mase ◽  
Mariko Yokogawa ◽  
Masanori Osawa ◽  
Ichio Shimada
Keyword(s):  
Ion Channel ◽  
G Protein ◽  
Potassium Ion ◽  
Structural Basis ◽  
Potassium Ion Channel ◽  
Α Subunit ◽  
G Protein Α Subunit ◽  
Inwardly Rectifying

Co-localization of the Inwardly Rectifying Potassium Ion Channel, Kir2.2, and the Substance P Receptor in Single Locus Coeruleus Neurons

1999 ◽  
Vol 897 (1 NEUROPEPTIDES) ◽  
pp. 429-431 ◽  
Author(s):  
ANTHONY H. STONEHOUSE ◽  
J. HOWARD PRINGLE ◽  
ROBERT I. NORMAN ◽  
PETER R. STANFIELD ◽  
EDWARD C. CONLEY ◽  
...  
Keyword(s):  
Substance P ◽  
Ion Channel ◽  
Locus Coeruleus ◽  
Potassium Ion ◽  
Single Locus ◽  
Potassium Ion Channel ◽  
Substance P Receptor ◽  
Inwardly Rectifying

Myrsinane and related diterpenes from Euphorbia falcata with selective potassium ion channel activity

Planta Medica ◽  
2015 ◽  
Vol 81 (16) ◽  
Author(s):  
A Vasas ◽  
P Orvos ◽  
L Tálosi ◽  
P Forgo ◽  
G Pinke ◽  
...  
Keyword(s):  
Ion Channel ◽  
Potassium Ion ◽  
Channel Activity ◽  
Potassium Ion Channel

scholarly journals The G-Protein α-Subunit GasC Plays a Major Role in Germination in the Dimorphic FungusPenicillium marneffei

Genetics ◽  
2003 ◽  
Vol 164 (2) ◽  
pp. 487-499 ◽  
Author(s):  
Sophie Zuber ◽  
Michael J Hynes ◽  
Alex Andrianopoulos
Keyword(s):  
G Protein ◽  
Germination Rate ◽  
Yeast Cells ◽  
Class Iii ◽  
Temperature Dependent ◽  
Gene Encoding ◽  
Α Subunit ◽  
G Protein Α Subunit ◽  
Opportunistic Human Pathogen

AbstractThe opportunistic human pathogen Penicillium marneffei exhibits a temperature-dependent dimorphic switch. At 25°, multinucleate, septate hyphae that can undergo differentiation to produce asexual spores (conidia) are produced. At 37° hyphae undergo arthroconidiation to produce uninucleate yeast cells that divide by fission. This work describes the cloning of the P. marneffei gasC gene encoding a G-protein α-subunit that shows high homology to members of the class III fungal Gα-subunits. Characterization of a ΔgasC mutant and strains carrying a dominant-activating gasCG45R or a dominant-interfering gasCG207R allele show that GasC is a crucial regulator of germination. A ΔgasC mutant is severely delayed in germination, whereas strains carrying a dominant-activating gasCG45R allele show a significantly accelerated germination rate. Additionally, GasC signaling positively affects the production of the red pigment by P. marneffei at 25° and negatively affects the onset of conidiation and the conidial yield, showing that GasC function overlaps with functions of the previously described Gα-subunit GasA. In contrast to the S. cerevisiae ortholog Gpa2, our data indicate that GasC is not involved in carbon or nitrogen source sensing and plays no major role in either hyphal or yeast growth or in the switch between these two forms.

Analysis by mRNA levels of the expression of six G protein α-subunit genes in mammalian cells and tissues

1991 ◽  
Vol 1094 (2) ◽  
pp. 193-199 ◽  
Author(s):  
Jermelina Linor R. Garibay ◽  
Tohru Kozasa ◽  
Hiroshi Itoh ◽  
Toshihiko Tsukamoto ◽  
Masaaki Matsuoka ◽  
...  
Keyword(s):  
G Protein ◽  
Mammalian Cells ◽  
Mrna Levels ◽  
Α Subunit ◽  
G Protein Α Subunit
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