scholarly journals Exosomes Derived from HIV-1-infected Cells Contain Trans-activation Response Element RNA

2013 ◽  
Vol 288 (27) ◽  
pp. 20014-20033 ◽  
Author(s):  
Aarthi Narayanan ◽  
Sergey Iordanskiy ◽  
Ravi Das ◽  
Rachel Van Duyne ◽  
Steven Santos ◽  
...  
Keyword(s):  
Response Element ◽  
Infected Cells ◽  
Activation Response ◽  
Hiv 1

scholarly journals Role of the Trans-activation Response Element in Dimerization of HIV-1 RNA

2004 ◽  
Vol 279 (21) ◽  
pp. 22243-22249 ◽  
Author(s):  
Ebbe S. Andersen ◽  
Sonia Antoranz Contera ◽  
Bjarne Knudsen ◽  
Christian K. Damgaard ◽  
Flemming Besenbacher ◽  
...  
Keyword(s):  
Response Element ◽  
Activation Response ◽  
Hiv 1

scholarly journals APOBEC3G Inhibits HIV-1 RNA Elongation by Inactivating the Viral Trans-Activation Response Element

2014 ◽  
Vol 426 (15) ◽  
pp. 2840-2853 ◽  
Author(s):  
Roni Nowarski ◽  
Ponnandy Prabhu ◽  
Edan Kenig ◽  
Yoav Smith ◽  
Elena Britan-Rosich ◽  
...  
Keyword(s):  
Response Element ◽  
Activation Response ◽  
Hiv 1

scholarly journals In vitro Evaluation of Bis-3-chloropiperidines as RNA Modulators Targeting TAR and TAR-protein Interaction

2021 ◽  
Author(s):  
Alice Sosic ◽  
Giulia Olivato ◽  
Caterina Carraro ◽  
Richard Göttlich ◽  
Dan Fabris ◽  
...  
Keyword(s):  
Protein Interaction ◽  
Chaperone Activity ◽  
Next Generation ◽  
Response Element ◽  
In Vitro Evaluation ◽  
Loop Domain ◽  
Activation Response ◽  
Hiv 1

After a long limbo, RNA has gained its credibility as a druggable target, fully earning its de-served role in the next-generation area of pharmaceutical R&D. We have recently probed the Trans-Activation Response element (TAR), a RNA stem–bulge–loop domain of the HIV-1 genome with bis-3-chloropiperidines (B-CePs), and revealed the compounds unique behavior in stabiliz-ing TAR structure, thus impairing in vitro the chaperone activity of the HIV-1 nucleocapsid (NC) protein. Seeking to elucidate the determinants of B-CePs inhibition, we have further characterized here their effects on the target TAR and its NC recognition, while developing quantitative analyti-cal approaches for the study of multicomponent RNA-based interactions.

scholarly journals Human GLI-2 Is a Tat Activation Response Element-Independent Tat Cofactor

2001 ◽  
Vol 75 (5) ◽  
pp. 2314-2323 ◽  
Author(s):  
Catherine M. Browning ◽  
Michael J. Smith ◽  
Nina M. Clark ◽  
Brian R. Lane ◽  
Camilo Parada ◽  
...  
Keyword(s):  
Regulatory Proteins ◽  
Tata Box ◽  
Hiv Replication ◽  
Response Element ◽  
Cyclin T1 ◽  
Gli Proteins ◽  
Dna Binding Site ◽  
Immunodeficiency Virus ◽  
Activation Response ◽  
Hiv 1

ABSTRACT Zinc finger-containing GLI proteins are involved in the development of Caenorhabditis elegans, Xenopus, Drosophila, zebrafish, mice, and humans. In this study, we show that an isoform of human GLI-2 strongly synergizes with the Tat transactivating proteins of human immunodeficiency virus types 1 and 2 (HIV-1 and -2) and markedly stimulates viral replication. GLI-2 also synergizes with the previously described Tat cofactor cyclin T1 to stimulate Tat function. Surprisingly, GLI-2/Tat synergy is not dependent on either a typical GLI DNA binding site or an intact Tat activation response element but does require an intact TATA box. Thus, GLI-2/Tat synergy results from a mechanism of action which is novel both for a GLI protein and for a Tat cofactor. These findings link the GLI family of transcriptional and developmental regulatory proteins to Tat function and HIV replication.

scholarly journals Conformational Dynamics of the HIV-1 Trans-Activation Response Element RNA Hairpin Bound to a Lab-Evolved Peptide

2018 ◽  
Vol 114 (3) ◽  
pp. 337a
Author(s):  
Chapin E. Cavender ◽  
Ivan A. Belashov ◽  
Joseph E. Wedekind ◽  
David H. Mathews
Keyword(s):  
Conformational Dynamics ◽  
Response Element ◽  
Activation Response ◽  
Rna Hairpin ◽  
Hiv 1

Identification of thienopyridine carboxamides as selective binders of HIV-1 trans Activation Response (TAR) and Rev Response Element (RRE) RNAs

2018 ◽  
Vol 16 (47) ◽  
pp. 9191-9196 ◽  
Author(s):  
Xue-Dong Li ◽  
Li Liu ◽  
Liang Cheng
Keyword(s):  
Structural Studies ◽  
Response Element ◽  
Rev Response Element ◽  
Activation Response ◽  
Hiv 1

The synthesis, biochemical and structural studies of two novel thienopyridine carboxamide derivatives that selectively recognize HIV-1 TAR and RRE RNAs were described.

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