Keap1-dependent Proteasomal Degradation of Transcription Factor Nrf2 Contributes to the Negative Regulation of Antioxidant Response Element-driven Gene Expression

Michael McMahon; Ken Itoh; Masayuki Yamamoto; John D. Hayes

doi:10.1074/jbc.m300931200

Keap1-dependent Proteasomal Degradation of Transcription Factor Nrf2 Contributes to the Negative Regulation of Antioxidant Response Element-driven Gene Expression

Journal of Biological Chemistry ◽

10.1074/jbc.m300931200 ◽

2003 ◽

Vol 278 (24) ◽

pp. 21592-21600 ◽

Cited By ~ 706

Author(s):

Michael McMahon ◽

Ken Itoh ◽

Masayuki Yamamoto ◽

John D. Hayes

Keyword(s):

Gene Expression ◽

Transcription Factor ◽

Proteasomal Degradation ◽

Antioxidant Response ◽

Negative Regulation ◽

Antioxidant Response Element ◽

Response Element

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Bach1 Competes with Nrf2 Leading to Negative Regulation of the Antioxidant Response Element (ARE)-mediated NAD(P)H:Quinone Oxidoreductase 1 Gene Expression and Induction in Response to Antioxidants

Journal of Biological Chemistry ◽

10.1074/jbc.m500166200 ◽

2005 ◽

Vol 280 (17) ◽

pp. 16891-16900 ◽

Cited By ~ 240

Author(s):

Saravanakumar Dhakshinamoorthy ◽

Abhinav K. Jain ◽

David A. Bloom ◽

Anil K. Jaiswal

Keyword(s):

Gene Expression ◽

Antioxidant Response ◽

Negative Regulation ◽

Antioxidant Response Element ◽

Response Element

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Characterization of Nrf1b, a Novel Isoform of the Nuclear Factor-Erythroid-2 Related Transcription Factor-1 That Activates Antioxidant Response Element-Regulated Genes

PLoS ONE ◽

10.1371/journal.pone.0048404 ◽

2012 ◽

Vol 7 (10) ◽

pp. e48404 ◽

Cited By ~ 5

Author(s):

Eric K. Kwong ◽

Kyung-Mi Kim ◽

Patrick J. Penalosa ◽

Jefferson Y. Chan

Keyword(s):

Transcription Factor ◽

Antioxidant Response ◽

Nuclear Factor ◽

Antioxidant Response Element ◽

Response Element ◽

Related Transcription Factor ◽

Transcription Factor 1

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Induction of quinone reductase NQO1 by resveratrol involves antioxidant response element ARE and is accompanied by nuclear translocation of transcription factor Nrf2

The FASEB Journal ◽

10.1096/fasebj.20.4.a82 ◽

2006 ◽

Vol 20 (4) ◽

Author(s):

Tze‐chen Hsieh ◽

Xiaohua Lu ◽

Zhirong Wang ◽

Joseph M Wu

Keyword(s):

Transcription Factor ◽

Nuclear Translocation ◽

Antioxidant Response ◽

Quinone Reductase ◽

Antioxidant Response Element ◽

Response Element

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Apoptosis Signal-Regulating Kinase-1 (ASK-1) Knockdown Augments Antioxidant Response Element (ARE)-Mediated Gene Expression Of Phase-II Antioxidant Enzymes (AOES) During Acute Hyperoxia (HO) Exposure

10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a5971 ◽

2011 ◽

Author(s):

Patrudu S. Makena ◽

Manik C. Ghosh ◽

Vijay K. Gorantla ◽

Lavanya Bezawada ◽

Charlean L. Luellen ◽

...

Keyword(s):

Gene Expression ◽

Antioxidant Enzymes ◽

Phase Ii ◽

Antioxidant Response ◽

Antioxidant Response Element ◽

Response Element

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Activation of Mitogen-activated Protein Kinase Pathways Induces Antioxidant Response Element-mediated Gene Expression via a Nrf2-dependent Mechanism

Journal of Biological Chemistry ◽

10.1074/jbc.m004037200 ◽

2000 ◽

Vol 275 (51) ◽

pp. 39907-39913 ◽

Cited By ~ 264

Author(s):

Rong Yu ◽

Chi Chen ◽

Yin-Yuan Mo ◽

Vidya Hebbar ◽

Edward D. Owuor ◽

...

Keyword(s):

Gene Expression ◽

Protein Kinase ◽

Antioxidant Response ◽

Mitogen Activated Protein Kinase ◽

Antioxidant Response Element ◽

Response Element ◽

Mitogen Activated Protein ◽

Dependent Mechanism

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Phosphorylation of Nrf2 at Ser40 by Protein Kinase C in Response to Antioxidants Leads to the Release of Nrf2 from INrf2, but Is Not Required for Nrf2 Stabilization/Accumulation in the Nucleus and Transcriptional Activation of Antioxidant Response Element-mediated NAD(P)H:Quinone Oxidoreductase-1 Gene Expression

Journal of Biological Chemistry ◽

10.1074/jbc.m307633200 ◽

2003 ◽

Vol 278 (45) ◽

pp. 44675-44682 ◽

Cited By ~ 345

Author(s):

David A. Bloom ◽

Anil K. Jaiswal

Keyword(s):

Gene Expression ◽

Protein Kinase C ◽

Protein Kinase ◽

Transcriptional Activation ◽

Antioxidant Response ◽

Antioxidant Response Element ◽

Response Element ◽

Kinase C

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Regulatory Mechanisms Controlling Gene Expression Mediated by the Antioxidant Response Element

Annals of the New York Academy of Sciences ◽

10.1196/annals.1323.001 ◽

2005 ◽

Vol 1055 (1) ◽

pp. 219-219 ◽

Cited By ~ 1

Author(s):

T. W. KENSLER

Keyword(s):

Gene Expression ◽

Antioxidant Response ◽

Regulatory Mechanisms ◽

Antioxidant Response Element ◽

Response Element

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Antioxidant response element cytoprotective response in aortic endothelial cells coordinated by transcription factor Nrf2 is regulated through frequency-modulated translocational oscillations

Atherosclerosis ◽

10.1016/j.atherosclerosis.2015.04.024 ◽

2015 ◽

Vol 241 (1) ◽

pp. e2

Author(s):

M. Xue ◽

H. Momiji ◽

N. Rabbani ◽

G. Barker ◽

T. Bretschneider ◽

...

Keyword(s):

Endothelial Cells ◽

Transcription Factor ◽

Antioxidant Response ◽

Antioxidant Response Element ◽

Response Element ◽

Aortic Endothelial Cells ◽

Cytoprotective Response ◽

Aortic Endothelial

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REGULATORY MECHANISMS CONTROLLING GENE EXPRESSION MEDIATED BY THE ANTIOXIDANT RESPONSE ELEMENT

The Annual Review of Pharmacology and Toxicology ◽

10.1146/annurev.pharmtox.43.100901.140229 ◽

2003 ◽

Vol 43 (1) ◽

pp. 233-260 ◽

Cited By ~ 850

Author(s):

Truyen Nguyen ◽

Philip J. Sherratt ◽

Cecil B. Pickett

Keyword(s):

Gene Expression ◽

Antioxidant Response ◽

Regulatory Mechanisms ◽

Antioxidant Response Element ◽

Response Element

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Role of protein kinase C δ in curcumin-induced antioxidant response element-mediated gene expression in human monocytes

Biochemical and Biophysical Research Communications ◽

10.1016/j.bbrc.2006.01.065 ◽

2006 ◽

Vol 341 (4) ◽

pp. 1007-1016 ◽

Cited By ~ 126

Author(s):

Stuart A. Rushworth ◽

Richard M. Ogborne ◽

Charles A. Charalambos ◽

Maria A. O’Connell

Keyword(s):

Gene Expression ◽

Protein Kinase C ◽

Protein Kinase ◽

Antioxidant Response ◽

Antioxidant Response Element ◽

Human Monocytes ◽

Response Element ◽

Kinase C

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