scholarly journals The MAZ transcription factor is a downstream target of the oncoprotein Cyr61/CCN1 and promotes pancreatic cancer cell invasion via CRAF–ERK signaling

2018 ◽  
Vol 293 (12) ◽  
pp. 4334-4349 ◽  
Author(s):  
Gargi Maity ◽  
Inamul Haque ◽  
Arnab Ghosh ◽  
Gopal Dhar ◽  
Vijayalaxmi Gupta ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Transcription Factor ◽  
Cancer Cell ◽  
Cell Invasion ◽  
Pancreatic Cancer Cell ◽  
Erk Signaling ◽  
Cancer Cell Invasion ◽  
Downstream Target

C6orf106 accelerates pancreatic cancer cell invasion and proliferation via activating ERK signaling pathway

2018 ◽  
Vol 454 (1-2) ◽  
pp. 87-95 ◽  
Author(s):  
Xin Li ◽  
Ming Dong ◽  
Jianping Zhou ◽  
Dehua Zhu ◽  
Jinbo Zhao ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Signaling Pathway ◽  
Cancer Cell ◽  
Cell Invasion ◽  
Pancreatic Cancer Cell ◽  
Erk Signaling ◽  
Cancer Cell Invasion

Pancreatic cancer cell invasion: mesenchymal switch or just hitchhiking?

2016 ◽  
Vol 5 (S6) ◽  
pp. S1093-S1097 ◽  
Author(s):  
Rémi Samain ◽  
Christine Jean ◽  
Corinne Bousquet
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Cell ◽  
Cell Invasion ◽  
Pancreatic Cancer Cell ◽  
Cancer Cell Invasion

COX-2 specific inhibitor reduces pancreatic cancer cell invasion through alteration of cellular adhesion and MMP activation

2001 ◽  
Vol 120 (5) ◽  
pp. A616
Author(s):  
Jiro Okami ◽  
Shoji Nakamori ◽  
Masato Sakon ◽  
Hirofumi Yamamoto ◽  
Nobuaki Hiraok ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Cell ◽  
Cell Invasion ◽  
Pancreatic Cancer Cell ◽  
Specific Inhibitor ◽  
Cellular Adhesion ◽  
Cancer Cell Invasion ◽  
Cox 2

3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors reduce human pancreatic cancer cell invasion and metastasis

2002 ◽  
Vol 122 (2) ◽  
pp. 308-317 ◽  
Author(s):  
Toshiyuki Kusama ◽  
Mutsuko Mukai ◽  
Teruo Iwasaki ◽  
Masaharu Tatsuta ◽  
Yoshirou Matsumoto ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Cell ◽  
Cell Invasion ◽  
Pancreatic Cancer Cell ◽  
Coenzyme A ◽  
Human Pancreatic Cancer ◽  
Cancer Cell Invasion ◽  
Human Pancreatic Cancer Cell ◽  
Invasion And Metastasis ◽  
Reductase Inhibitors

scholarly journals Kallikrein 7 enhances pancreatic cancer cell invasion by shedding E-cadherin

Cancer ◽  
2007 ◽  
Vol 109 (9) ◽  
pp. 1811-1820 ◽  
Author(s):  
Sarah K. Johnson ◽  
Vishnu C. Ramani ◽  
Leah Hennings ◽  
Randy S. Haun
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Cell ◽  
Cell Invasion ◽  
Pancreatic Cancer Cell ◽  
Cancer Cell Invasion ◽  
E Cadherin

scholarly journals GSK3β mediates pancreatic cancer cell invasion in vitro via the CXCR4/MMP-2 Pathway

2015 ◽  
Vol 15 (1) ◽  
Author(s):  
Xu Ying ◽  
Li Jing ◽  
Shijie Ma ◽  
Qianjun Li ◽  
Xiaoling Luo ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Cell ◽  
Cell Invasion ◽  
Pancreatic Cancer Cell ◽  
Cancer Cell Invasion

scholarly journals Localization of KRAS downstream target ARL4C to invasive pseudopods accelerates pancreatic cancer cell invasion

eLife ◽  
2021 ◽  
Vol 10 ◽  
Author(s):  
Akikazu Harada ◽  
Shinji Matsumoto ◽  
Yoshiaki Yasumizu ◽  
Toshiyuki Akama ◽  
Hidetoshi Eguchi ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Patients ◽  
Cancer Cell ◽  
Cell Invasion ◽  
Cancer Cell Invasion ◽  
Interacting Protein ◽  
Downstream Target ◽  
Downstream Effector ◽  
Pancreatic Cancer Cells ◽  
Specific Localization

Pancreatic cancer has a high mortality rate due to metastasis. Whereas KRAS is mutated in most pancreatic cancer patients, controlling KRAS or its downstream effectors has not been succeeded clinically. ARL4C is a small G protein whose expression is induced by the Wnt and EGF-RAS pathways. In the present study, we found that ARL4C is frequently overexpressed in pancreatic cancer patients and showed that its localization to invasive pseudopods is required for cancer cell invasion. IQGAP1 was identified as a novel interacting protein for ARL4C. ARL4C recruited IQGAP1 and its downstream effector, MMP14, to invasive pseudopods. Specific localization of ARL4C, IQGAP1, and MMP14 was the active site of invasion, which induced degradation of the extracellular matrix. Moreover, subcutaneously injected antisense oligonucleotide against ARL4C into tumor-bearing mice suppressed metastasis of pancreatic cancer. These results suggest that ARL4C-IQGAP1-MMP14 signaling is activated at invasive pseudopods of pancreatic cancer cells.

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