Anti-inflammatory effect of the hydralcoholic extract of Zingiber officinale rhizomes on rat paw and skin edema

Purpose: To evaluate the effect of denatonium benzoate (DB) in histamine-induced model of inflammation and the effect of the selective H1 receptor agonist (2-(2-Pyridyl) ethylamine) on rat gastric smooth muscle strips pretreated with DB.Methods: The anti-inflammatory effect of DB was evaluated in vivo on histamine-induced rat paw edema. In vitro studies on spontaneous muscle contraction were performed on smooth muscle strips isolated from rat gastric corpus.Results: The results showed a well-defined anti-inflammatory effect of DB (15 mg/kg) during the early stage of rat paw edema at the 15th (p < 0.001), 30th (p < 0.01) and 60th min (p < 0.001) compared to control. In vitro experiments indicated reduced spontaneous contractile activity of smooth muscle strips to H1 receptor agonist in the presence of DB (0.5 μM). The vascular effects of histamine are mediated by H1 receptors. Substances, which reduce the effect of histamine on the H1 receptors could influence the early stage of histamine-induced inflammation.Conclusion: The results show that the anti-inflammatory activity of DB probably is related to its antagonistic activity on histamine H1 receptors. The results would contribute to the search for new antiinflammatory drugs. Keywords: Denatonium benzoate, Inflammation, Histamine, Muscle contraction

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Anti-Inflammatory Evaluation of NLC (Nanostructured Lipid Carriers) Meloxicam In-Vivo

International Journal of Drug Delivery Technology ◽

10.25258/ijddt.v7i04.10657 ◽

2017 ◽

Vol 7 (04) ◽

Author(s):

Widyaningrum I. ◽

Hariyadi D. M. ◽

Hendradi E.

Keyword(s):

Particle Size ◽

Research Result ◽

Entrapment Efficiency ◽

Solid Lipid ◽

Rat Paw Edema ◽

Auc Value ◽

Anti Inflammatory ◽

Rat Paw ◽

Inflammatory Effect

Objective: The aim of this research study was to investigate the anti-inflammatory effect of NLC meloxicam. NLC contains solid and liquid lipid. Monostearin as solid lipid and Miglyol 808 as liquid lipid. Methods : NLC meloxicam was repared using emulsification methodwith three different lipid ratio. . NLC meloxicam was prepared and characterized for measuring the pH, viscocity, particle size, and entrapment efficiency. The rat paw edema test was performed to evaluate the antiinflammatory activity of three formulations NLC meoxicam. Results : based on research result shows that the smaller the solid lipid concentrations, particle size is the larger, the greater viscosity, thus increasing occlusive NLC to the skin. The third formula hasthe greatest solid lipid concentration shows the smallest AUC value but once in a statistical test known to be significantly different from the three formulas. Conclusions : NLC meloxicam showed that it had anti-inflammatory effectiveness

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Effect of Essential Oils from Ginger (Zingiber officinale) and Turmeric (Curcuma longa) Rhizomes on Some Inflammatory Biomarkers in Cadmium Induced Neurotoxicity in Rats

Journal of Toxicology ◽

10.1155/2018/4109491 ◽

2018 ◽

Vol 2018 ◽

pp. 1-7 ◽

Cited By ~ 3

Author(s):

Ayodele Jacob Akinyemi ◽

Philip Adeyemi Adeniyi

Keyword(s):

Prefrontal Cortex ◽

Essential Oil ◽

Essential Oils ◽

Neurological Diseases ◽

Curcuma Longa ◽

Zingiber Officinale ◽

Inflammatory Biomarkers ◽

Tnf Alpha ◽

Anti Inflammatory ◽

Inflammatory Effect

Studies have revealed that anti-inflammatory agents could provide beneficial effect in lowering the incidence/progression of neurological diseases. Hence, this study sought to investigate the effect of essential oils from Nigeria ginger and turmeric rhizomes on some cytokines in cadmium induced neurotoxicity. The result revealed that essential oil from ginger and turmeric rhizomes exerts anti-inflammatory effect by preventing alterations of some cytokines/inflammatory biomarkers (IL-6, IL-10 and TNF-Alpha) levels and inhibits both hippocampus and prefrontal cortex acetylcholinesterase (AChE) and adenosine deaminase (ADA) activities (important enzymes relevant in the management/prevention of neurodegenerative diseases) in Cd treated rats. In conclusion, essential oil from ginger and turmeric rhizomes exerts anti-inflammatory properties in Cd induced neurotoxicity. The observed effect could be due to the volatile compounds as revealed by GC-MS analysis.

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PRELIMINARY PHYTOCHEMICAL SCREENING AND ANTI-INFLAMMATORY EFFECT OF THE AQUEOUS EXTRACT OF TABERNAEMONTANA DIVARICATA FLOWER IN WISTER RATS

International Journal of Current Pharmaceutical Research ◽

10.22159/ijcpr.2017v9i5.22128 ◽

2017 ◽

pp. 9-12

Author(s):

Deepankar Garga ◽

Trishna Das

Keyword(s):

Aqueous Extract ◽

Inflammatory Activity ◽

Phytochemical Analysis ◽

Standard Drug ◽

Tabernaemontana Divaricata ◽

Rat Paw Edema ◽

Oil Extract ◽

Anti Inflammatory ◽

Rat Paw ◽

Inflammatory Effect

Objective: To determine the phytochemical analysis and anti-inflammatory effect of the aqueous extract of Tabernaemontanadivaricata flower in Wister Rats.Methods: The aqueous extract of fresh flowers of the plant Tabernaemontanadivaricata (family-Apocyanaceae) were prepared and analyzed for phytochemical constituents using standard methods. The anti-inflammatory activity of the plant extracts was examined with the help of rat models by taking diclofenac as a standard drug against T. divericata oil extract by using carrageenan induced rat paw edema method with the help of the instrument plethesmometer.Results: The present experiment shows the phytochemical analysis, anti-inflammatory activity of the aqueous extract of fresh flowers of the plant Tabernaemontanadivaricata (family-Apocyanaceae). Various phytochemical analysis revealed the presence of saponins, flavonoids, glycosides, steroids, proteins, phenols, amino acids and tannins. The oil extract of the plant showed much effective anti-inflammatory activity against the standard drug.Conclusion: It can be concluded aqueous extract of the flower of the plant Tabernaemontanadivaricata (family-Apocyanaceae) contain the high presence of phytochemicals. This extract was found to possess promising antimicrobial activity when compared with the standards.

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Influence of metaprot and hypoxen on the inflammatory reaction development in the experiment

Reviews on Clinical Pharmacology and Drug Therapy ◽

10.17816/rcf10463-66 ◽

2012 ◽

Vol 10 (4) ◽

pp. 63-66

Author(s):

Vasiliy Yegorovich Novikov ◽

Sergey Alekseyevich Ilyukhin ◽

Yelena Vasilyevna Pozhilova

Keyword(s):

Free Radical ◽

Acetylsalicylic Acid ◽

Free Radical Oxidation ◽

Acute Inflammatory Response ◽

Paw Edema ◽

Radical Oxidation ◽

Enteral Administration ◽

Anti Inflammatory ◽

Rat Paw ◽

Inflammatory Effect

The dynamics of the acute inflammatory response was observed in the experiment modeling caragenin-induced rat paw inflammation. The changes in the volume of damaged limb (paw edema) and indices of free radical oxidation were registered. Acetylsalicylic acid in the dose of 100 mg/kg was shown to reduce the development of inflammation. Hypoxen and metaprot in the dose of 50 mg/kg have got low anti-inflammatory activity, but potentiated the effect of acetylsalicylic acid. Simultaneous enteral administration of hypoxen and metaprot with the acetylsalicylic acid during the treatment with caragenin the powerful anti-inflammatory effect was marked, it was presented with a significant decrease in the parameters of inflammation recorded and rapid recovery of the damaged limb. The combination of hypoxen with acetylsalicylic acid was the most effective one.

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