Veterinary and pharmacological approaches to abnormal repetitive behaviour.

2009 ◽  
pp. 286-324 ◽  
Author(s):  
D. Mills ◽  
A. Luescher
Keyword(s):  
Repetitive Behaviour

The influence of degree of adaptation to tether-housing by sows in relation to behaviour and energy metabolism

1986 ◽  
Vol 42 (2) ◽  
pp. 257-268 ◽  
Author(s):  
G. M. Cronin ◽  
J. M. F. M. van Tartwijk ◽  
W. van der Hel ◽  
M. W. A. Verstegen
Keyword(s):  
Heat Production ◽  
Light Period ◽  
Metabolizable Energy ◽  
Activity Level ◽  
Repetitive Behaviour ◽  
Limited Experience ◽  
Behavioural Patterns ◽  
High Incidence ◽  
Group 2 ◽  
Metabolizable Energy Intake

ABSTRACTIn response to tethering, many sows develop seemingly non-functional repetitive behaviour (stereotypies), which may be performed for several hours in a day.The quality and quantity of activity performed by sows with different degrees of adaptation to tethering was studied in relation to energy expenditure. Three groups of five sows were recognized: (1) High, sows which showed a high incidence of stereotyped activity after prolonged tethering; (2) T/Low, sows with limited experience of tethers; and (3) G/Low, the same sows as in group 2 after regrouping.High sows were about three times more active than T/Low sows: the proportions of time involved in 24 h were 0·35 and 0·13 respectively. Most of the former sows' activity was in the form of sterotypies. The activity level of the G/Low sows was between that of the two tether treatments (proportionately 0·17 of 24 h). Both tethered treatments spent proportionately about 0·05 of 24 h in using drinkers compared with proportionately less than 0·02 of the time for the G/Low sows.High sows produced proportionately 0·36 more heat than T/Low sows during the 12-h light period in each day. During this period, proportionately 0·40 and 0·20 of heat production from High and T/Low sows was associated with activity. The diurnal activity of the G/Low sows was associated with proportionately 0·24 of heat production.Stereotypies and excessive drinker use accounted for proportionately 0·86, 0·52 and 0·24 of the activity of High, T/Low and G/Low sows. The proportions of metabolizable energy intake required for these activities were 0·23, 0·07 and 0·04 respectively for the three treatments. The study concludes that tethering is stressful when sows develop, and then indulge in frequent coping behavioural patterns which increase metabolic rate.

scholarly journals Character Development Creativity in Unit Blocks for Visual Spatial Intellegence Improvement of Children with Special Needs

2021 ◽  
Vol 2 (2) ◽  
Author(s):  
Muhammad Imam Tobroni
Keyword(s):  
Neurodevelopmental Disorder ◽  
Children With Autism ◽  
Repetitive Behaviour ◽  
Spatial Intelligence ◽  
Autism Treatment ◽  
Visual Spatial ◽  
Unit Block ◽  
Character Design ◽  
Different Shapes ◽  
Vision Therapy

Autism is a neurodevelopmental disorder that is present from birth or early childhood. People with autism usually have impaired social interaction, difficulties in verbal and non- verbal communication, and repetitive behaviour. One of the forms of autism treatment is therapy. Vision therapy through toys that require concentration and creativity is able to treat autism as it won’t limit the imagination of children with the disorder. Toys usually have their own patterns and programs that tend to limit children’s creativity, imagination and visual and spatial intelligence. This can lead to children’s stress and lack of confidence. A character design on unit block toys is a form of vision therapy. It develops children’s visual and spatial creativity and intelligence. It also helps children to be independent and helps with their perception. Unit blocks consist of pieces of wooden blocks with different shapes and sizes that can form even bigger shapes, based on children’s imagination and ability to design a space or a building. Children’s visual and spatial intelligence help them visualize and notice shapes, colours, spaces, and designs of the unit blocks accurately, modify their surroundings based upon their perceptions, and recreate the aspects of their visual experiences. Playing Lego blocks will help develop the visual spatial intelligence of children with autism as it stimulates their ability to express ideas and to design a character the way they like. 

Spotlight on a mouse model of obsessive-compulsive disorder

2013 ◽  
Vol 28 (S2) ◽  
pp. 17-17
Author(s):  
E. Burguière
Keyword(s):  
Basal Ganglia ◽  
Mouse Model ◽  
Obsessive Compulsive Disorder ◽  
Response Inhibition ◽  
Mutant Mouse ◽  
Repetitive Behavior ◽  
Inhibitory Neurons ◽  
Obsessive Compulsive ◽  
Repetitive Behaviour ◽  
Compulsive Disorder

It has been shown these last years that optogenetic tool, that uses a combination of optics and genetics technics to control neuronal activity with light on behaving animals, allows to establish causal relationship between brain activity and normal or pathological behaviors [3]. In combination with animal model of neuropsychiatric disorder, optogenetic could help to identify deficient circuitry in numerous pathologies by exploring functional connectivity, with a specificity never reached before, while observing behavioral and/or physiological correlates. To illustrate the promising potential of these tools for the understanding of psychiatric diseases, we will present our recent study where we used optogenetic to block abnormal repetitive behavior in a mutant mouse model of obsessive-compulsive disorder [1]. Using a delay-conditioning task we showed that these mutant mouse model had a deficit in response inhibition that lead to repetitive behaviour. With optogenetic, we could stimulate a specific circuitry in the brain that connect the orbitofrontal cortex with the basal ganglia; a circuitry that has been shown to be dysfunctional in compulsive behaviors. We observed that these optogenetic stimulations, through their effect on inhibitory neurons of the basal ganglia, could restore the behavioral response inhibition and alleviate the compulsive behavior. These findings raise promising potential for the design of targeted deep brain stimulation therapy for disorders involving excessive repetitive behavior and/or for the optimization of already existing stimulation protocol [2].

scholarly journals Placental neurosteroids shape cerebellar development and social behaviour

2019 ◽  
Author(s):  
Claire-Marie Vacher ◽  
Jiaqi J. O’Reilly ◽  
Jacquelyn Salzbank ◽  
Helene Lacaille ◽  
Dana Bakalar ◽  
...  
Keyword(s):  
Brain Structures ◽  
Autism Spectrum ◽  
Late Gestation ◽  
Strong Positive Correlation ◽  
Repetitive Behaviour ◽  
Gene Encoding ◽  
Gaba A ◽  
Positive Modulator ◽  
Placental Hormone ◽  
Male Specific

ABSTRACTCompromised placental function or premature loss has been linked to diverse neurodevelopmental disorders 1,2. The placenta is the first functional foetal endocrine organ, but the direct impact of placental hormone loss on foetal brain in late gestation has not been empirically tested. Allopregnanolone (ALLO) is a non-glucocorticoid, progesterone derivative that acts as a positive modulator of GABA-A receptor activity3 with the potential to alter critical GABA-mediated developmental processes 4,5. To directly test the role of placental ALLO, we generated a novel mouse model in which the gene encoding the synthetic enzyme for ALLO (Akr1c14) is specifically deleted in trophoblasts using a tissue-specific Cre-Lox strategy. ALLO concentrations are significantly decreased in late gestation in placenta and brain when placental Akr1c14 is removed, indicating placenta as the primary gestational ALLO source. We now demonstrate that targeted placental ALLO loss leads to permanent changes in brain development in a sex- and regionally-specific manner. Placental ALLO insufficiency led to male-specific cerebellar white matter (WM) abnormalities characterized by excess myelination with increased myelin protein expression, similar to changes reported in boys with autism spectrum disorders (ASD)6,7. Behavioural testing of these mice revealed increased repetitive behaviour and sociability deficits, two hallmarks of ASD, only in male offspring with placental ALLO insufficiency. Notably, a strong positive correlation was seen between the cerebellar contents of myelin basic protein (MBP) and the severity of ASD-like behaviours. A single injection of ALLO during gestation was sufficient to rescue both cerebellar MBP levels and aberrant behaviours. This study reveals a new role for a placental hormone in shaping specific brain structures and behaviours, and suggests that identifying placental hormone insufficiency or preterm loss may offer novel therapeutic opportunities to prevent later neurobehavioural disorders.

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