Cytological criteria of malignancy.

Malignant pheochromocytoma is a rare disease and surgical resectionis the only curative treatment. There are no definitive histologicalor cytological criteria of malignancy, as it is impossible todetermine this condition in the absence of advanced locoregionaldisease or metastases. We report a case of a patient with a giantretroperitoneal tumour, the second largest to be published, whichwas diagnosed as a malignant pheochromocytoma; it was treatedwith surgery. The literature is reviewed to evaluate tumour featuresand criteria to distinguish between benign and malignantpheochromocytomas.

Download Full-text

Malignant female adnexal tumour of probable Wolffian origin: criteria of malignancy

Histopathology ◽

10.1111/j.1365-2559.2005.02035.x ◽

2005 ◽

Vol 46 (6) ◽

pp. 716-718 ◽

Cited By ~ 9

Author(s):

E Sivridis ◽

A Giatromanolaki ◽

N Koutlaki ◽

P Anastasiadis

Keyword(s):

Criteria Of Malignancy ◽

Adnexal Tumour

Download Full-text

Criteria of Malignancy

Radiology ◽

10.1148/37.5.521 ◽

1941 ◽

Vol 37 (5) ◽

pp. 521-532

Author(s):

Allen Graham

Keyword(s):

Criteria Of Malignancy

Download Full-text

Giant Malignant Pheochromocytoma with Palpable Rib Metastases

Case Reports in Urology ◽

10.1155/2014/354687 ◽

2014 ◽

Vol 2014 ◽

pp. 1-4 ◽

Cited By ~ 3

Author(s):

Esat Korgali ◽

Gokce Dundar ◽

Gokhan Gokce ◽

Fatih Kilicli ◽

Sahande Elagoz ◽

...

Keyword(s):

Retroperitoneal Tumor ◽

Malignant Pheochromocytoma ◽

Neuroendocrine Neoplasm ◽

Therapeutic Approaches ◽

Multiple Metastases ◽

Potentially Malignant ◽

Criteria Of Malignancy

Pheochromocytoma is a rare and usually benign neuroendocrine neoplasm. Only 10% of all these tumors are malignant and there are no definitive histological or cytological criteria of malignancy. Single malignancy criteria are the presence of advanced locoregional disease or metastases. We report a case, with a giant retroperitoneal tumor having multiple metastases including palpable rib metastases, who was diagnosed as a malignant pheochromocytoma. The patient was treated with surgery. The literature was reviewed to evaluate tumor features and current diagnostic and therapeutic approaches for patients with metastatic or potentially malignant pheochromocytoma.

Download Full-text

Mesoblastic tumours following intraperitoneal injections of 1 : 2 : 5 : 6-Dibenzanthracene in a fatty medium

Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character ◽

10.1098/rspb.1932.0054 ◽

1932 ◽

Vol 111 (771) ◽

pp. 238-247 ◽

Cited By ~ 18

Keyword(s):

Connective Tissue ◽

Olive Oil ◽

Intraperitoneal Injection ◽

Pure Form ◽

Carcinogenic Substance ◽

Gum Acacia ◽

Subcutaneous Tissues ◽

Criteria Of Malignancy ◽

Fluorescent Spectra ◽

Rats And Mice

Attention was first drawn to 1 : 2 : 5 : 6-dibenzanthracene as a carcinogenic substance during an inquiry into the fluorescent spectra of coal tars carried out by W. Y. Mayneord in collaboration with E. L. Kennaway at this Institute in 1927 and later continued by I. Hieger (1930). Since then the substance has been prepared in a very pure form by J. W. Cook (1931, a), who has made some closely allied compounds which are also carcinogenic (1931, b, c; 1932). Kennaway (1930) and Hieger (1930) have already recorded the causation of epitheliomata by 1:2:5: 6-dibenzanthracene dissolved in benzene applied to the skin of mice ; and Burrows, Hieger and Kennaway (1932) have described the production of connective tissue tumours in rats and mice by injecting 1:2:5: 6-dibenzanthracene dissolved in lard into the subcutaneous tissues. These tumours conformed to the usually accepted criteria of malignancy; grafted strains have now reached the 23rd and 36th generation in mice and the 18th and 20th generation in rats. Technique . The present paper sets out some results of the intraperitoneal injection of fatty solutions of 1 : 2 : 5 : 6-dibenzanthracene. This substance was dissolved in a concentration of 0 • 4 per cent, in olive oil by heating at temperatures not exceeding 100° and the solution was then emulsified in 3 volumes of 5 per cent, gum acacia in water usually made alkaline to 8·2 in order to assist emulsification. The concentration of the hydrocarbon in the emulsion was thus 0·1 per cent.*

Download Full-text

Solitary Fibrous Tumor of the Pancreas: A Case Report and Review of the Literature

PRILOZI ◽

10.1515/prilozi-2016-0024 ◽

2016 ◽

Vol 37 (2-3) ◽

pp. 115-120 ◽

Cited By ~ 3

Author(s):

Liljana Spasevska ◽

Vesna Janevska ◽

Vlado Janevski ◽

Biljana Noveska ◽

Julija Zhivadinovik

Keyword(s):

Solitary Fibrous Tumor ◽

Epigastric Pain ◽

Pancreatic Tissue ◽

Biological Behavior ◽

Radiologic Findings ◽

Cystic Component ◽

Long Time ◽

History Of ◽

Criteria Of Malignancy ◽

Fibrous Tumor

Abstract Pancreas is an extremely rare abdominal localization of the solitary fibrous tumor (SFT). It usually grows asymptomatically for a long time before a diagnosis can be made on the basis of symptoms and/or mechanical complications. Due to the rarity and nonspecific clinical presentation, this entity is diagnostically challenging. We present a 47-year-old man with a history of progressive epigastric pain for the last two weeks, and jaundice, who was admitted to hospital for further investigation. Cystadenocarcinoma was suspected based on the radiologic findings, and a pancreatoduodenectomy was performed. The removed portion of the pancreas contained a 3.5 × 2 × 1.8 cm well-circumscribed, but not encapsulated white tumor mass with smooth cut surface, cystic component and duct dilatation within the tumor and within the adjacent pancreatic tissue. Based on the histology and immunostaining profile, a diagnosis of the solitary fibrous tumor was made. One week post-operatively, the patient died due to surgical complications. Microscopic and immunohistochemical examinations are necessary for accurate diagnosis of cystic SFT of the pancreas. Because there is limited data regarding the biological behavior of SFT with extra-pleural localization the authors recommend clinical follow-up for SFT treatment if the criteria of malignancy are not met.

Download Full-text

Canine smooth muscle tumors: A clinicopathological study

Veterinary Pathology ◽

10.1177/03009858211066862 ◽

2021 ◽

pp. 030098582110668

Author(s):

Giancarlo Avallone ◽

Valeria Pellegrino ◽

Luisa Vera Muscatello ◽

Paola Roccabianca ◽

Gastone Castellani ◽

...

Keyword(s):

Smooth Muscle ◽

Soft Tissue ◽

Genital Tract ◽

Female Genital Tract ◽

Mitotic Count ◽

Labeling Index ◽

Ki67 Labeling Index ◽

Smooth Muscle Tumors ◽

Criteria Of Malignancy ◽

Female Genital

Canine smooth muscle tumors (SMTs) commonly develop in the alimentary and female genital tracts and less frequently in soft tissue. The definition of histological criteria of malignancy is less detailed for SMTs in dogs than in humans. This study evaluated the clinicopathologic features of canine SMTs and compared the veterinary and human medical criteria of malignancy. A total of 105 canine SMTs were evaluated histologically and classified according to both veterinary and human criteria. The Ki67 labeling index was assessed in all SMTs. Estrogen receptor (ER) and progesterone receptor (PR) expression was evaluated for soft tissue SMTs. Follow-up data were available in 25 cases. SMTs were diagnosed in the female genital tract (42%), alimentary tract (22%), and soft tissue (20%). Soft tissue SMTs frequently arose in the perigenital area, pelvic cavity, and retroperitoneum. A subset of soft tissue SMTs expressed ER and/or PR, resembling the gynecologic type of soft tissue SMT in humans. SMTs were less frequently malignant when assessed with human criteria than with veterinary criteria, better reflecting their benign behavior, especially in the genital tract where human criteria tolerate a higher mitotic count for leiomyoma. Decreased differentiation was correlated with increased proliferation, necrosis, and reduced desmin expression. Mitotic count, Ki67 labeling index, and necrosis were correlated with metastases and tumor-related death. Further prognostic studies are warranted to confirm the better performance of the human criteria when assessing SMT malignancy, especially genital cases, to confirm their usefulness in ER/PR-expressing soft tissue SMTs, and to better define the most useful prognostic parameters for canine SMTs.

Download Full-text