scholarly journals Mesoblastic tumours following intraperitoneal injections of 1 : 2 : 5 : 6-Dibenzanthracene in a fatty medium

1932 ◽  
Vol 111 (771) ◽  
pp. 238-247 ◽  
Keyword(s):  
Connective Tissue ◽  
Olive Oil ◽  
Intraperitoneal Injection ◽  
Pure Form ◽  
Carcinogenic Substance ◽  
Gum Acacia ◽  
Subcutaneous Tissues ◽  
Criteria Of Malignancy ◽  
Fluorescent Spectra ◽  
Rats And Mice

Attention was first drawn to 1 : 2 : 5 : 6-dibenzanthracene as a carcinogenic substance during an inquiry into the fluorescent spectra of coal tars carried out by W. Y. Mayneord in collaboration with E. L. Kennaway at this Institute in 1927 and later continued by I. Hieger (1930). Since then the substance has been prepared in a very pure form by J. W. Cook (1931, a), who has made some closely allied compounds which are also carcinogenic (1931, b, c; 1932). Kennaway (1930) and Hieger (1930) have already recorded the causation of epitheliomata by 1:2:5: 6-dibenzanthracene dissolved in benzene applied to the skin of mice ; and Burrows, Hieger and Kennaway (1932) have described the production of connective tissue tumours in rats and mice by injecting 1:2:5: 6-dibenzanthracene dissolved in lard into the subcutaneous tissues. These tumours conformed to the usually accepted criteria of malignancy; grafted strains have now reached the 23rd and 36th generation in mice and the 18th and 20th generation in rats. Technique . The present paper sets out some results of the intraperitoneal injection of fatty solutions of 1 : 2 : 5 : 6-dibenzanthracene. This substance was dissolved in a concentration of 0 • 4 per cent, in olive oil by heating at temperatures not exceeding 100° and the solution was then emulsified in 3 volumes of 5 per cent, gum acacia in water usually made alkaline to 8·2 in order to assist emulsification. The concentration of the hydrocarbon in the emulsion was thus 0·1 per cent.*

Lipoma of the left tonsillar fossa

1994 ◽  
Vol 108 (6) ◽  
pp. 507-508 ◽  
Author(s):  
R. Benson-Mitchell ◽  
N. Tolley ◽  
C. B. Croft ◽  
D. Roberts
Keyword(s):  
Adipose Tissue ◽  
Connective Tissue ◽  
Literature Review ◽  
Clinical Presentation ◽  
Aerodigestive Tract ◽  
Upper Aerodigestive Tract ◽  
Tonsillar Fossa ◽  
Subcutaneous Tissues

AbstractLipomas are common benign connective tissue tumours composed of adult adipose tissue. They are relatively rare in the upper aerodigestive tract, although they occur with considerable frequency in other areas, particularly in the subcutaneous tissues of the neck. Although there are several reports of this tumour occurring in the oropharynx, there is no recorded case of a lipoma of the tonsillar fossa. An 83-year-old man with a left tonsillar fossa lipoma is presented. Clinical presentation, management and a literature review are discussed.

COMPARATIVE EVALUATION OF NEW OSTEOPLASTIC MATERIALS BASED ON THE RESULTS OF ACUTE TOXICITY STUDIES

2021 ◽  
Vol Special issue (2) ◽  
pp. 29-33
Author(s):  
А.N. Akbarov ◽  
◽  
N.S. Ziyadullaeva
Keyword(s):  
Bioactive Glass ◽  
Intraperitoneal Injection ◽  
Comparative Evaluation ◽  
Laboratory Animals ◽  
Toxic Substances ◽  
Series Of Experiments ◽  
Osteoplastic Material ◽  
Rats And Mice ◽  
Lethal Doses

Three series of experiments were carried out and lethal doses of the new osteoplastic material 47.5 V were determined by the intraperitoneal and intragastric injection of the material to laboratory animals. A comparative evaluation with Bioactive glass BG-1D was also carried out. It was found that the LD50of 47,5B was 4274.51:4770.58 mg/kg for intragastric injection and 2358.31:2895.65 mg/kg for intraperitoneal injection to rats. In animals getting Bioactive glass BG-1D, these indicators changed slightly, amounting to 3439.04:3810.53 mg/kg and 1732.77:2730.93 mg/kg, respectively. Thus, according to the classification of substances according to the degree of toxicity, these materials can be attributed to practically non-toxic substances (according to the results of intraperitoneal injection of the material suspension to rats and mice) and low-toxic substances (according to the results of intragastric injection of the material suspension to rats)

Antinociception induced by intraperitoneal injection of gentamicin in rats and mice

Pain ◽  
1990 ◽  
Vol 41 (3) ◽  
pp. 365-371 ◽  
Author(s):  
W. A. Prado ◽  
C. R. Tonussi ◽  
E. M. Rego ◽  
A. P. Corrado
Keyword(s):  
Intraperitoneal Injection ◽  
Rats And Mice

THE VARIATION WITH BODY WEIGHT OF THE WATER-BINDING PROPERTIES OF COMMON CONNECTIVE TISSUE

1961 ◽  
Vol 39 (10) ◽  
pp. 1535-1542
Author(s):  
Michael C. Hall
Keyword(s):  
Body Weight ◽  
Connective Tissue ◽  
Linear Relationship ◽  
Albino Rats ◽  
Binding Properties ◽  
Binding Ability ◽  
Water Binding ◽  
Velocity Constant ◽  
Subcutaneous Tissues ◽  
Standard Pressure

A standard volume of saline was introduced at standard pressure into the reflected subcutaneous tissues in 79 male albino rats, forming gelatinous bullae. The rate at which the saline was lost from the bullae after it had been dissected free was estimated by periodic weighings, and a velocity constant of this rate was derived. There was found to be a linear relationship between this constant and the weight of the animal. It is believed that the injected saline combines with the connective tissue, and that the alteration with body weight of the rate of loss of the saline subsequent to the injection is an expression of the change of the water-binding ability of this tissue.

Dietary lipid modulation of connective tissue matrix in rat abdominal aorta

1992 ◽  
Vol 262 (3) ◽  
pp. R389-R394 ◽  
Author(s):  
D. D. Hodgkin ◽  
R. D. Gilbert ◽  
P. J. Roos ◽  
L. B. Sandberg ◽  
R. J. Boucek
Keyword(s):  
Fatty Acid ◽  
Connective Tissue ◽  
Olive Oil ◽  
Morphometric Analysis ◽  
Corn Oil ◽  
Dietary Lipid ◽  
Low Fat ◽  
Abdominal Aortic ◽  
Connective Tissue Matrix ◽  
Tissue Matrix

Dietary lipid modulation of structural and passive mechanical properties of isolated rat abdominal aortic segments were assessed during the early developmental period. Rats were raised from conception to 90 days of age on semisynthetic diets containing various types and amounts of lipids. Aortic segments from three groups of rats fed high-fat diets (15%, wt/wt) consisting of olive oil, corn oil, or lard as the sole lipid sources were compared with those from rats fed a low-fat control diet containing corn oil (5%, wt/wt). Morphometric analysis of the tunica media demonstrated that rats raised on diets with a relatively low polyunsaturated fatty acid content (olive oil and lard) had greater numbers of elastic lamellae than rats raised on diets with opposite fatty acid indexes (high- and low-fat corn oil). Changes in elastin content of the tunica media, determined biochemically, paralleled those seen by morphometric analysis of the elastic lamellar number. Altered dietary fatty acid ratios were also associated with changes in smooth muscle cell number. In this regard, a decreased cellular density was observed in the olive oil and lard diets compared with the corn oil diet. The olive oil diet was unique amongst the dietary lipid regimens in raising, whereas the lard-containing diet lowered, indexes of aortic tissue elasticity. These results demonstrate an effect of chronic feeding of high dietary fat on the composition and biomechanical properties of the connective tissue matrix of abdominal aortic rings from young Sprague-Dawley rats.

Uptake of liposome-entrapped mannitol by diaphragm

1979 ◽  
Vol 57 (7) ◽  
pp. 756-759 ◽  
Author(s):  
K. Nakatsu ◽  
D. A. Cameron
Keyword(s):  
Intraperitoneal Injection ◽  
Tissue Uptake ◽  
Rats And Mice

Tissue uptake of liposome-entrapped radioactive mannitol was examined in rats and mice after both intravenous and intraperitoneal injection. In accord with results from other laboratories, liver and spleen effectively accumulated liposomes. Diaphragm also took up significant amounts of label. In nearly all cases the radioactive content of perfused tissues was less than tissues which were not perfused but this was statistically significant in only a few comparisons.

THE INHIBITION OF TRYPTOPHAN PYRROLASE BY ALLOPURINOL, AN INHIBITOR OF XANTHINE OXIDASE

1967 ◽  
Vol 45 (11) ◽  
pp. 1667-1672 ◽  
Author(s):  
G. C. Becking ◽  
W. J. Johnson
Keyword(s):  
Xanthine Oxidase ◽  
Intraperitoneal Injection ◽  
Plasma Tryptophan ◽  
Single Intraperitoneal Injection ◽  
Tryptophan Pyrrolase ◽  
Noncompetitive Inhibitor ◽  
In Vitro Inhibition ◽  
Rats And Mice

The effect of allopurinol (4-hydroxypyrazolo(3,4-d)pyrimidine) on tryptophan pyrrolase activity of rats and mice was determined. After a single intraperitoneal injection of allopurinol at levels equal to or slightly greater than those given orally for the treatment of gout in humans, the drug was found to be an inhibitor of tryptophan pyrrolase activity. After injection of allopurinol, rats excreted significantly less kynurenine, but the drug did not alter plasma tryptophan levels. A study was made of the in vitro inhibition of tryptophan pyrrolase by allopurinol. The drug was found to be a very potent noncompetitive inhibitor of tryptophan pyrrolase with a Ki value of 8 × 10−7 M. Allopurinol at 1.5 × 10−6 M concentration inhibited the enzyme 50%.

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