A Sensitive Electrochemical Assay for Early Detection of HIV-1 Protease Using Ferrocene-Peptide Conjugate/Au Nanoparticle/Single Walled Carbon Nanotube Modified Electrode

A rapid, simple, and sensitive method for the electrochemical determination of paracetamol was developed. A single-walled carbon nanotube/nickel (SWCNT/Ni) nanocomposite was prepared and immobilized on a glassy carbon electrode (GCE) surface via mechanical attachment. This paper reports the voltammetry study on the effect of paracetamol concentration, scan rate, pH, and temperature at a SWCNT/Ni-modified electrode in the determination of paracetamol. The characterization of the SWCNT/Ni/GCE was performed by cyclic voltammetry. Variable pressure scanning electron microscopy (VPSEM) and energy dispersive X-ray (EDX) spectrometer were used to examine the surface morphology and elemental profile of the modified electrode, respectively. Cyclic voltammetry showed significant enhancement in peak current for the determination of paracetamol at the SWCNT/Ni-modified electrode. A linear calibration curve was obtained for the paracetamol concentration between 0.05 and 0.50 mM. The SWCNT/Ni/GCE displayed a sensitivity of 64 mA M−1and a detection limit of 1.17 × 10−7 M in paracetamol detection. The proposed electrode can be applied for the determination of paracetamol in real pharmaceutical samples with satisfactory performance. Results indicate that electrodes modified with SWCNT and nickel nanoparticles exhibit better electrocatalytic activity towards paracetamol.

Download Full-text

A Metal-Free, Non-Enzymatic Electrochemical Glucose Sensor with a de-Bundled Single-Walled Carbon Nanotube-Modified Electrode

Bulletin of the Korean Chemical Society ◽

10.1002/bkcs.11358 ◽

2017 ◽

Vol 39 (2) ◽

pp. 141-145 ◽

Cited By ~ 2

Author(s):

Dinakaran Thirumalai ◽

Devaraju Subramani ◽

Bosung Shin ◽

Hyun-jong Paik ◽

Seung-Cheol Chang

Keyword(s):

Carbon Nanotube ◽

Modified Electrode ◽

Glucose Sensor ◽

Single Walled Carbon Nanotube ◽

Metal Free ◽

Single Walled Carbon

Download Full-text

Achievements of Mesoporous Carbon Solution and Single-Walled Carbon Nanotube Composite on the Sensitive Electrochemical Assay of Ivabradine

Analytica ◽

10.3390/analytica2040017 ◽

2021 ◽

Vol 2 (4) ◽

pp. 195-205

Author(s):

Merve Yence ◽

Leyla Karadurmus ◽

Goksu Ozcelikay ◽

Nurgul K. Bakirhan ◽

Sibel A. Ozkan

Keyword(s):

Carbon Nanotube ◽

Mesoporous Carbon ◽

Urine Analysis ◽

Calibration Plot ◽

Electrochemical Assay ◽

Experimental Conditions ◽

Single Walled Carbon Nanotube ◽

Single Walled Carbon ◽

Serum And Urine

In this study, the electrochemical determination of Ivabradine hydrochloride (IH) was studied in detail using a glassy carbon electrode (GCE) modified with mesoporous carbon solution (MCS) and carboxylated group linked single-walled carbon nanotube (SWCNT-COOH). The developed nanosensor showed a significant effect by remarkably increasing the IH signal compared with the bare GCE. Cyclic (CV) and differential pulse voltammetric (DPV) methods were applied to perform electrochemical analysis of IH in pH 3.0 BRB solutions. The calibration plot for IH with a detection limit of 1.47 × 10−7 M was obtained using the DPV technique in the range of 1–10 µM under optimum experimental conditions. The proposed method has been validated and applied for the detection of the IH tablet. The produced nanosensor was also performed for the determination of IH in serum and urine. Excellent recoveries of 98.4%, 98.0%, and 100.2% were achieved for tablet, serum, and urine analysis, respectively.

Download Full-text