Achievements of Mesoporous Carbon Solution and Single-Walled Carbon Nanotube Composite on the Sensitive Electrochemical Assay of Ivabradine

In this study, the electrochemical determination of Ivabradine hydrochloride (IH) was studied in detail using a glassy carbon electrode (GCE) modified with mesoporous carbon solution (MCS) and carboxylated group linked single-walled carbon nanotube (SWCNT-COOH). The developed nanosensor showed a significant effect by remarkably increasing the IH signal compared with the bare GCE. Cyclic (CV) and differential pulse voltammetric (DPV) methods were applied to perform electrochemical analysis of IH in pH 3.0 BRB solutions. The calibration plot for IH with a detection limit of 1.47 × 10−7 M was obtained using the DPV technique in the range of 1–10 µM under optimum experimental conditions. The proposed method has been validated and applied for the detection of the IH tablet. The produced nanosensor was also performed for the determination of IH in serum and urine. Excellent recoveries of 98.4%, 98.0%, and 100.2% were achieved for tablet, serum, and urine analysis, respectively.

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Single-Walled-Carbon-Nanotube-Modified Pyrolytic Graphite Electrode Used as a Simple Sensor for the Determination of Salbutamol in Urine

International Journal of Electrochemistry ◽

10.4061/2011/373498 ◽

2011 ◽

Vol 2011 ◽

pp. 1-8 ◽

Cited By ~ 3

Author(s):

Rajendra N. Goyal ◽

Sunita Bishnoi ◽

Bharati Agrawal

Keyword(s):

Carbon Nanotube ◽

Human Urine ◽

Graphite Electrode ◽

Pyrolytic Graphite ◽

Phosphate Buffer Solution ◽

Calibration Plot ◽

Single Walled Carbon Nanotube ◽

Single Walled Carbon ◽

Pyrolytic Graphite Electrode

A fast and sensitive voltammetric method has been proposed for the determination of salbutamol at single-walled-carbon-nanotube-modified edge-plane pyrolytic graphite electrode (SWNT/EPPGE) in human urine. The electrochemical response of salbutamol was determined by square wave voltammetry (SWV) in phosphate buffer solution (PBS) at physiological pH 7.2. The modified electrode showed improved voltammetric response towards the oxidation of salbutamol, and a well-defined anodic peak was observed at~600 mV with enhanced peak current in comparison to the bare electrode. Linear calibration plot using SWNT/EPPGE was obtained in the concentration range of 50 to 2500 ngml-1with sensitivity and detection limit of 2.15 nA/ngml-1and 4.31 ngml-1, respectively. The developed method has been successfully applied for the determination of salbutamol in commercial preparations and human body fluids. Fast analysis of salbutamol in human urine makes the proposed method of great interest for doping control purposes at the site of competitive games.

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Determination of the Absolute Potential of the Single-walled Carbon Nanotube Energy Levels Using Attached Hydrogenase Enzymes

ECS Meeting Abstracts ◽

10.1149/ma2007-01/25/1023 ◽

2007 ◽

Keyword(s):

Carbon Nanotube ◽

Energy Levels ◽

Single Walled Carbon Nanotube ◽

Single Walled Carbon ◽

The Absolute ◽

Hydrogenase Enzymes ◽

Absolute Potential

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Electrocatalytic Study of Paracetamol at a Single-Walled Carbon Nanotube/Nickel Nanocomposite Modified Glassy Carbon Electrode

Advances in Materials Science and Engineering ◽

10.1155/2015/742548 ◽

2015 ◽

Vol 2015 ◽

pp. 1-8 ◽

Cited By ~ 7

Author(s):

Koh Sing Ngai ◽

Wee Tee Tan ◽

Zulkarnain Zainal ◽

Ruzniza Mohd Zawawi ◽

Joon Ching Juan

Keyword(s):

Cyclic Voltammetry ◽

Carbon Nanotube ◽

Glassy Carbon Electrode ◽

Modified Electrode ◽

Glassy Carbon ◽

Carbon Electrode ◽

Single Walled Carbon Nanotube ◽

Paracetamol Concentration ◽

Single Walled Carbon

A rapid, simple, and sensitive method for the electrochemical determination of paracetamol was developed. A single-walled carbon nanotube/nickel (SWCNT/Ni) nanocomposite was prepared and immobilized on a glassy carbon electrode (GCE) surface via mechanical attachment. This paper reports the voltammetry study on the effect of paracetamol concentration, scan rate, pH, and temperature at a SWCNT/Ni-modified electrode in the determination of paracetamol. The characterization of the SWCNT/Ni/GCE was performed by cyclic voltammetry. Variable pressure scanning electron microscopy (VPSEM) and energy dispersive X-ray (EDX) spectrometer were used to examine the surface morphology and elemental profile of the modified electrode, respectively. Cyclic voltammetry showed significant enhancement in peak current for the determination of paracetamol at the SWCNT/Ni-modified electrode. A linear calibration curve was obtained for the paracetamol concentration between 0.05 and 0.50 mM. The SWCNT/Ni/GCE displayed a sensitivity of 64 mA M−1and a detection limit of 1.17 × 10−7 M in paracetamol detection. The proposed electrode can be applied for the determination of paracetamol in real pharmaceutical samples with satisfactory performance. Results indicate that electrodes modified with SWCNT and nickel nanoparticles exhibit better electrocatalytic activity towards paracetamol.

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