Endemie Trypanosoma cruzi infection in Indian populations of the Gran Chaco territory of South America: performance of diagnostic assays and epidemiological features

SUMMARYCalculating epidemiological measures of infection by Trypanosoma cruzi, the causative agent of Chagas disease, is complex, because it involves several species, different stages of infection in humans and multiple transmission routes. Using the next-generation matrix method, we analysed a model which considers the three stages of human infection, triatomines and dogs (the main domestic reservoirs of T. cruzi when triatomines are present) and the main transmission routes. We derived R0 and type-reproduction numbers T. We deduced formulas for the number of new infections generated through each transmission route by each infected individual. We applied our findings in Argentine Gran Chaco. The expressions achieved allowed quantifying the high infectivity of dogs and emphasizing the epidemiological importance of the long and asymptomatic chronic indeterminate stage in humans in the spread of the infection. According to the model, it is expected that one infected human infects 21 triatomines, that 100 infected triatomines are necessary to infect one human and 34 to infect a dog, and that each dog infects on average one triatomine per day. Our results may allow quantifying the effect of control measures on infected humans, triatomines and dogs (or other highly infected vertebrate) or on a specific route of transmission, in other scenarios.

Download Full-text

Seroprevalence of Trypanosoma cruzi infection and vector control activities in rural communities of the southern Gran Chaco (Argentina)

Acta Tropica ◽

10.1016/j.actatropica.2009.11.007 ◽

2010 ◽

Vol 113 (3) ◽

pp. 257-262 ◽

Cited By ~ 5

Author(s):

Mariana Laura Moreno ◽

Edgardo Moretti ◽

Beatriz Basso ◽

Maria Frias Céspedes ◽

Silvia S. Catalá ◽

...

Keyword(s):

Rural Communities ◽

Trypanosoma Cruzi ◽

Vector Control ◽

Gran Chaco ◽

Cruzi Infection

Download Full-text

Clinical and epidemiological features of chronic Trypanosoma cruzi infection in patients with HIV/AIDS in Buenos Aires, Argentina

International Journal of Infectious Diseases ◽

10.1016/j.ijid.2017.11.027 ◽

2018 ◽

Vol 67 ◽

pp. 118-121 ◽

Cited By ~ 4

Author(s):

Andrés Guillermo Benchetrit ◽

Marisa Fernández ◽

Amadeo Javier Bava ◽

Marcelo Corti ◽

Norma Porteiro ◽

...

Keyword(s):

Trypanosoma Cruzi ◽

Buenos Aires ◽

Epidemiological Features ◽

Cruzi Infection ◽

Hiv Aids

Download Full-text

Serological follow-up of Trypanosoma cruzi infection from 1987 to 1994 in 32 counties of the State of Jalisco, Mexico: preliminary report

Cadernos de Saúde Pública ◽

10.1590/s0102-311x1995000300026 ◽

1995 ◽

Vol 11 (3) ◽

pp. 501-505

Author(s):

Francisco Trujillo-Contreras ◽

Maria Angeles V. Yerenas

Keyword(s):

Immune Response ◽

South America ◽

Trypanosoma Cruzi ◽

Preliminary Report ◽

The State ◽

Laboratory Techniques ◽

The University ◽

Mexican Strains ◽

Cruzi Infection

In 1987 the University of Guadalajara performed a seroepidemiological survey on the prevalence of Chagas’ disease in the 124 counties of the State of Jalisco, Mexico, arriving at a rate of 21.6 per 100 inhabitants. From December 1993 to June 1994, we studied 2238 individuals from 32 rural counties in this State. Of these, we found 276 positives (12.33%) and 1962 negatives (87.66%). Nevertheless, the series of serological differences found are very striking, since out of the 655 individuals that were seropositive in 1987, we noted that 276 individuals remained positive, while 50 individuals (7.63%) became negative. There were no flaws in the laboratory techniques. We believe that either the immune response of Mexicans is different or that the virulence of the Mexican strains of Trypanosoma cruzi may be not as great as that in the South America countries.

Download Full-text