Persistent effects of the orexin-1 receptor antagonist SB-334867 on naloxone precipitated morphine withdrawal symptoms and nociceptive behaviors in morphine dependent rats

2020 ◽  
pp. 1-10
Author(s):  
Masoumeh Kourosh-Arami ◽  
Mohammad-Taghi Joghataei ◽  
Alireza Komaki ◽  
Masoumeh Gholami ◽  
Zohreh Najafi ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Morphine Withdrawal ◽  
Withdrawal Symptoms

The selective cholecystokininB receptor antagonist L-365,260 diminishes the expression of naloxone-induced morphine withdrawal symptoms in normal and neuropathic rats

Life Sciences ◽  
1998 ◽  
Vol 62 (10) ◽  
pp. 947-952 ◽  
Author(s):  
Valérie Kayser ◽  
Juhana J. Idänpään-Hekkilä ◽  
Dennis Christensen ◽  
Gisèle Guilbaud
Keyword(s):  
Receptor Antagonist ◽  
Morphine Withdrawal ◽  
Withdrawal Symptoms

A new way to treat morphinism

1930 ◽  
Vol 26 (10) ◽  
pp. 1056-1056
Author(s):  
M. Sokel
Keyword(s):  
Morphine Withdrawal ◽  
Withdrawal Symptoms ◽  
New Treatment

Abstracts. Neuropathology and Psychiatry. Dr. M. Sokel describes (D. m. W. 1930, no. 42) a new treatment for morphinism. With the sudden withdrawal of morphine to avoid the phenomena of morphine withdrawal a. in the first 6-8 days he injected a large amount of insulin (up to 80 units of insulin "Leo" in 24 hours) without wine. Sahara. The amount of insulin depended on the severity of the withdrawal symptoms. A total of 15 patients were treated.

Mefloquine attenuated morphine withdrawal symptoms in rat

2016 ◽  
Vol 26 ◽  
pp. S688-S689
Author(s):  
S. Moradi ◽  
R. Motahari ◽  
K. Hassanzadeh
Keyword(s):  
Morphine Withdrawal ◽  
Withdrawal Symptoms

Evaluation on the Treatment of Morphine Addiction by Acupuncture Chinese Herbs and Opioid Peptides

1986 ◽  
Vol 14 (01n02) ◽  
pp. 46-50 ◽  
Author(s):  
Mabel M.P. Yang ◽  
John S. L. Kwok
Keyword(s):  
Opioid Peptides ◽  
Side Effect ◽  
Experimental Studies ◽  
Sedative Effect ◽  
Morphine Withdrawal ◽  
Chinese Herbs ◽  
Withdrawal Symptoms ◽  
Morphine Addiction ◽  
Supplementary Treatment

Experimental studies on the effects of acupuncture, combined Chinese herbs, and opioid peptides on morphine withdrawal symptoms were carried out in 119 addicted rats. Electroacupuncture was found to be the most effective method as it reduced the morphine withdrawal scores to -85%. The combined herbs, Qiang Huo, Gou Teng, Chuan Xion, Fu Zi and Yan Hu Suo suppressed the withdrawal scores of – 68%. The opioid peptides, endorphin, enkephalin, and dynorphin, produced marked sedative effect and alleviated the withdrawal symptoms, reducing the scores from -28% to -74%. It is suggested that acupuncture and herbs, being non-opiate and having less side effect, might be used as alternative supplementary treatment on morphine addiction.

Long-term treatment with SR141716A, the CB1 receptor antagonist, influences morphine withdrawal syndrome

Life Sciences ◽  
2000 ◽  
Vol 66 (22) ◽  
pp. 2213-2219 ◽  
Author(s):  
Tiziana Rubino ◽  
Paola Massi ◽  
Daniela Viganò ◽  
Domenica Fuzio ◽  
Daniela Parolaro
Keyword(s):  
Receptor Antagonist ◽  
Withdrawal Syndrome ◽  
Cb1 Receptor ◽  
Term Treatment ◽  
Morphine Withdrawal ◽  
Long Term Treatment ◽  
Cb1 Receptor Antagonist

Effects of morphine withdrawal on catecholaminergic neurons on heart right ventricle; implication of dopamine receptors

2001 ◽  
Vol 79 (10) ◽  
pp. 885-891 ◽  
Author(s):  
M V Milanés ◽  
M T Marín ◽  
M L Laorden
Keyword(s):  
Right Ventricle ◽  
Receptor Antagonist ◽  
Dopamine Receptors ◽  
Biochemical Analysis ◽  
Sch 23390 ◽  
Receptor Activation ◽  
Morphine Withdrawal ◽  
Dopamine Turnover ◽  
Catecholaminergic Neurons ◽  
The Right

The purpose of our study was to examine the effects of D1-and D2-dopamine receptors blockade on the changes in the ventricular content of catecholamines in rats withdrawn from morphine. Rats were given morphine by subcutaneous (sc) implantation of morphine pellets for 5 days. On the eighth day, morphine withdrawal was induced by sc administration of naloxone (1 mg/kg), and rats were killed 30 min later. Pretreatment with SCH 23390 (dopamine D1, D5 receptor antagonist) 15 min prior to naloxone administration suppressed some the behavioural signs of morphine withdrawal, whereas eticlopride (dopamine D2, D3, D4 receptor antagonist) did not. In addition, biochemical analysis indicate that SCH 23390 completely abolished the withdrawal-induced increase in noradrenaline and dopamine turnover in the right ventricle. By contrast, eticlopride did not block the hyperactivity of catecholaminergic neurons in the heart during morphine withdrawal. These data suggest that the hyperactivity of catecholaminergic neurons in the heart during morphine withdrawal is dependent upon D1 dopamine receptor activation. In addition, our results exclude the involvement of D2 dopamine receptors.Key words: morphine withdrawal, right ventricle, catecholaminergic activity.

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