Effects of a pneumatic tube system on the hemolysis of blood samples: a PRISMA-compliant meta-analysis

Abstract Context.—Technologic advances affecting analyzers used in clinical laboratories have changed the methods used to obtain many laboratory measurements, and many novel parameters are now available. The effects of specimen transport through a pneumatic tube system on laboratory results obtained with such modern instruments are unclear. Objective.—To determine the effects of sample transport through a pneumatic tube system on routine and novel hematology and coagulation parameters obtained on state-of-the-art analyzers. Design.—Paired blood samples from 33 healthy volunteers were either hand delivered to the clinical laboratory or transported through a pneumatic tube system. Results.—No statistically significant differences were observed for routine complete blood cell count and white cell differential parameters or markers of platelet activation, such as the mean platelet component, or of red cell fragmentation. When 2 donors who reported aspirin intake were excluded from the analysis, there was a statistically, but not clinically, significant impact of transport through the pneumatic tube system on the mean platelet component. There were no statistically significant differences for prothrombin time, activated partial thromboplastin time, waveform slopes for prothrombin time or activated partial thromboplastin time, fibrinogen, or fibrin monomers. Conclusions.—Although further study regarding the mean platelet component may be required, transport through a pneumatic tube system has no clinically significant effect on hematology and coagulation results obtained with certain modern instruments in blood samples from healthy volunteers.

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Hemolysis Associated With Pneumatic Tube System Transport For Blood Samples

Pakistan Journal of Medical Sciences ◽

10.12669/pjms.301.4228 ◽

1969 ◽

Vol 30 (1) ◽

Author(s):

Hasan Kara ◽

Aysegul Bayir ◽

Ahmet Ak ◽

Selim Degirmenci ◽

Murat Akinci ◽

...

Keyword(s):

Tube System ◽

Blood Samples ◽

Pneumatic Tube ◽

Pneumatic Tube System

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Are TEG®results in healthy blood donors affected by the transport of blood samples in a pneumatic tube system?

International Journal of Laboratory Hematology ◽

10.1111/ijlh.12494 ◽

2016 ◽

Vol 38 (4) ◽

pp. e73-e76 ◽

Cited By ~ 4

Author(s):

A. Espinosa ◽

A. Ruckert ◽

J. Navarro ◽

V. Videm ◽

B. V. Sletta

Keyword(s):

Blood Donors ◽

Tube System ◽

Blood Samples ◽

Pneumatic Tube ◽

Pneumatic Tube System

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Immunologic Studies of Blood Samples Transported by a Pneumatic Tube System

American Journal of Clinical Pathology ◽

10.1093/ajcp/68.4.508 ◽

1977 ◽

Vol 68 (4) ◽

pp. 508-510 ◽

Cited By ~ 3

Author(s):

Robert M. Greendyk ◽

Jane C. Banzhaf ◽

Sophia Pelysko ◽

Beverly Bauman

Keyword(s):

Tube System ◽

Blood Samples ◽

Pneumatic Tube ◽

Pneumatic Tube System

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The impact of pneumatic tube system on routine laboratory parameters: a systematic review and meta-analysis

Clinical Chemistry and Laboratory Medicine (CCLM) ◽

10.1515/cclm-2017-0008 ◽

2017 ◽

Vol 55 (12) ◽

Cited By ~ 7

Author(s):

Georgia V. Kapoula ◽

Panagiota I. Kontou ◽

Pantelis G. Bagos

Keyword(s):

Systematic Review ◽

Clinical Effect ◽

Meta Analysis ◽

Routine Laboratory ◽

Tube System ◽

Laboratory Parameters ◽

Pneumatic Tube ◽

The Mean ◽

The Impact ◽

Pneumatic Tube System

AbstractBackground:Pneumatic tube system (PTS) is a widely used method of transporting blood samples in hospitals. The aim of this study was to evaluate the effects of the PTS transport in certain routine laboratory parameters as it has been implicated with hemolysis.Methods:A systematic review and a meta-analysis were conducted. PubMed and Scopus databases were searched (up until November 2016) to identify prospective studies evaluating the impact of PTS transport in hematological, biochemical and coagulation measurements. The random-effects model was used in the meta-analysis utilizing the mean difference (MD). Heterogeneity was quantitatively assessed using the Cohran’sResults:From a total of 282 studies identified by the searching procedure, 24 were finally included in the meta-analysis. The meta-analysis yielded statistically significant results for potassium (K) [MD=0.04 mmol/L; 95% confidence interval (CI)=0.015–0.065; p=0.002], lactate dehydrogenase (LDH) (MD=10.343 U/L; 95% CI=6.132–14.554; p<10Conclusions:This meta-analysis suggests that PTS may be associated with alterations in K, LDH and AST measurements. Although these findings may not have any significant clinical effect on laboratory results, it is wise that each hospital validates their PTS.

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Pneumatic tube validation: Reducing the need for donor samples by integrating a vial-embedded data logger

Annals of Clinical Biochemistry International Journal of Laboratory Medicine ◽

10.1177/0004563221992822 ◽

2021 ◽

pp. 000456322199282

Author(s):

Ida Stangerup ◽

Franziska Broell ◽

Julie van der Hoop ◽

Henriette P Sennels

Keyword(s):

Lactate Dehydrogenase ◽

Laboratory Data ◽

Area Under The Curve ◽

Tube System ◽

Data Logger ◽

Blood Samples ◽

Pneumatic Tube ◽

The Stability ◽

Pneumatic Tube System

Background The most common way to validate a pneumatic tube system is to compare pneumatic tube system-transported blood samples to blood samples carried by hand. The importance of measuring the forces inside the pneumatic tube system has also been emphasized. The aim of this study was to define a validation protocol using a mini data logger (VitalVial, Motryx Inc., Canada) to reduce the need for donor samples in pneumatic tube system validation. Methods As an indicator of the total vibration, the blood samples are exposed to under pneumatic tube system transportation; the area under the curve was determined by a VitalVial for all hospital Tempus600 lines using a five-day validation protocol. Only the three lines with the highest area under the curves were clinically validated by analysing potassium, lactate dehydrogenase and aspartate aminotransferase. A month after pneumatic tube system commissioning, a follow-up on laboratory data was performed. Results Mean area under the curve of the six lines ranged between 347 and 581. The variability of the area under the curve was between 1.51 and 11.55%. In the laboratory data follow-up, an increase in lactate dehydrogenase haemolysis was seen from the three lines with the highest area under the curve and the emergency department, which was not detected in the clinical validation. When the Tempus600 system was in commission, a higher mean area under the curve was measured. Conclusion A three-day validation protocol using VitalVials is enough to determine the stability of a Tempus600 system and can greatly reduce the need for donor samples. When in commission, the stability of the pneumatic tube system should be verified and lactate dehydrogenase haemolysis should be routinely checked.

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