Subjective health complaints and quality of life in patients with irritable bowel syndrome followingGiardia lambliainfection: A case control study

ABSTRACT BACKGROUND: Irritable bowel syndrome is a functional and chronic gastrointestinal disorder that may cause abdominal pain and altered bowel habits, affecting the nutritional status and quality of life of its carriers. Its prevalence is high, affecting about 10% to 15% of the general population in developed countries, being more prevalent in women than in men in the proportion 2:1. OBJECTIVE: The aim of our study was to compare the profile of body adiposity, life habits, and the quality of life of women with irritable bowel syndrome with a healthy control group. METHODS: Case-control study on 70 women, 34 with irritable bowel syndrome and 36 healthy. We applied the “Irritable Bowel Syndrome Quality of Life Questionnaire”to assess quality of life. Body adiposity was assessed from body mass index, waist circumference, and waist-to-hip ratio. We investigated the self-reporting of gastrointestinal symptoms with food deemed as problematic for carriers of irritable bowel syndrome and the presence of typical comorbidities. Assessment of life habits included: practice of physical activities, alcoholism, smoking, daytime sleepiness, and exclusion of foods from the feeding routine. For statistical analysis we used the IBM SPSS program, with a significance level at 5%. RESULTS: There was higher volume of central and general adiposity in the case group compared with the control group (P<0.05). Cases presented a higher chance of developing IBS-related comorbidities (P<0.05). About of 80% of patients with irritable bowel syndrome have excluded some food from the diet (P<0.01) and the total amount of troublesome foods varied from 7 to 21 (P<0.01). The case group featured worse quality of life compared with the control (P<0.05). CONCLUSION: Compared to the control group, women with irritable bowel syndrome showed greater body adiposity, higher frequency of comorbidities, greater restriction on the consumption of problematic foods and worse quality of life.

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Faculty Opinions recommendation of Prevalence of small intestinal bacterial overgrowth in children with irritable bowel syndrome: a case-control study.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1164023.624683 ◽

2009 ◽

Author(s):

Annamaria Staiano ◽

Roberta Buonavolontà

Keyword(s):

Irritable Bowel Syndrome ◽

Case Control Study ◽

Bacterial Overgrowth ◽

Small Intestinal Bacterial Overgrowth ◽

Case Control ◽

Intestinal Bacterial Overgrowth ◽

Small Intestinal ◽

Irritable Bowel ◽

Control Study

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Irritable bowel syndrome and Parkinson’s disease risk: register-based studies

npj Parkinson s Disease ◽

10.1038/s41531-020-00145-8 ◽

2021 ◽

Vol 7 (1) ◽

Author(s):

Bojing Liu ◽

Arvid Sjölander ◽

Nancy L. Pedersen ◽

Jonas F. Ludvigsson ◽

Honglei Chen ◽

...

Keyword(s):

Parkinson’S Disease ◽

Irritable Bowel Syndrome ◽

Case Control Study ◽

Case Control ◽

Twin Registry ◽

Increased Risk ◽

Irritable Bowel ◽

Nested Case Control ◽

Control Study ◽

Swedish Twin Registry

AbstractTo examine whether irritable bowel syndrome (IBS) was related to the future risk of Parkinson’s disease (PD), we conducted a nested case-control study in the Swedish total population including 56,564 PD cases identified from the Swedish Patient Register and 30 controls per case individually matched by sex and year of birth. Odds ratios (ORs) with 95% confidence intervals (CIs) for having a prior diagnosis of IBS were estimated using conditional logistic regression. We furthermore conducted a cohort study using the Swedish Twin Registry following 3046 IBS patients identified by self-reported abdominal symptoms and 41,179 non-IBS individuals. Through Cox proportional hazard models, we estimated hazard ratios (HRs) and 95% CIs for PD risk. In the nested case-control study, 253 (0.4%) PD cases and 5204 (0.3%) controls had a previous IBS diagnosis. IBS diagnosis was associated with a 44% higher risk of PD (OR = 1.44, 95% CI 1.27–1.63). Temporal relationship analyses showed 53% and 38% increased risk of PD more than 5 and 10 years after IBS diagnosis, respectively. In the cohort analysis based on the Swedish Twin Registry, there was no statistically significantly increased risk of PD related to IBS (HR = 1.25, 95% CI = 0.87–1.81). Our results suggest a higher risk of PD diagnosis after IBS. These results provide additional evidence supporting the importance of the gut–brain axis in PD.

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