Evaluation of species differences in the metabolism of the selective NaV1.7 inhibitor DS-1971a, a mixed substrate of cytochrome P450 and aldehyde oxidase

Xenobiotica ◽  
2021 ◽  
pp. 1-43
Author(s):  
Daigo Asano ◽  
Takahiro Shibayama ◽  
Hideyuki Shiozawa ◽  
Shin-ichi Inoue ◽  
Tsuyoshi Shinozuka ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Species Differences ◽  
Aldehyde Oxidase ◽  
Mixed Substrate

Species differences in hepatic and intestinal metabolic activities for 43 human cytochrome P450 substrates between humans and rats or dogs

Xenobiotica ◽  
2013 ◽  
Vol 43 (11) ◽  
pp. 948-955 ◽  
Author(s):  
Haruka Nishimuta ◽  
Tetsuya Nakagawa ◽  
Naruaki Nomura ◽  
Masashi Yabuki
Keyword(s):  
Cytochrome P450 ◽  
Species Differences ◽  
Human Cytochrome ◽  
Metabolic Activities

Species Differences in Intestinal Metabolic Activities of Cytochrome P450 isoforms between Cynomolgus Monkeys and Humans

2011 ◽  
Vol 26 (3) ◽  
pp. 300-306 ◽  
Author(s):  
Haruka Nishimuta ◽  
Kimihiko Sato ◽  
Yasuyuki Mizuki ◽  
Masashi Yabuki ◽  
Setsuko Komuro
Keyword(s):  
Cytochrome P450 ◽  
Species Differences ◽  
Cynomolgus Monkeys ◽  
Cytochrome P450 Isoforms ◽  
Metabolic Activities

Species differences in enantioselective 2-oxidations of RS-8359, a selective and reversible MAO-A inhibitor, and cinchona alkaloids by aldehyde oxidase

2006 ◽  
Vol 27 (3) ◽  
pp. 133-139 ◽  
Author(s):  
Kunio Itoh ◽  
Mayumi Yamamura ◽  
Wataru Takasaki ◽  
Takamitsu Sasaki ◽  
Akiko Masubuchi ◽  
...  
Keyword(s):  
Species Differences ◽  
Aldehyde Oxidase ◽  
Cinchona Alkaloids ◽  
Mao A

Strain Difference of Oxidative Metabolism of the Sedative-hypnotic Zaleplon by Aldehyde Oxidase and Cytochrome P450 In Vivo and In Vitro in Rats

2013 ◽  
Vol 28 (3) ◽  
pp. 269-273 ◽  
Author(s):  
Chiaki Tanoue ◽  
Kazumi Sugihara ◽  
Naoto Uramaru ◽  
Yoko Watanabe ◽  
Yoshitaka Tayama ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Oxidative Metabolism ◽  
Strain Difference ◽  
Aldehyde Oxidase

Species differences in the covalent binding of [14C]tamoxifen to liver microsomes and the forms of cytochrome P450 involved

1995 ◽  
Vol 49 (8) ◽  
pp. 1035-1042 ◽  
Author(s):  
Ian N.H. White ◽  
Francesco De Matteis ◽  
Anthony H. Gibbs ◽  
Chang Kee Lim ◽  
C.Roland Wolf ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Species Differences ◽  
Covalent Binding ◽  
Liver Microsomes
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