EM algorithm-based likelihood estimation for a generalized Gompertz regression model in presence of survival data with long-term survivors: an application to uterine cervical cancer data

2017 ◽  
Vol 87 (9) ◽  
pp. 1712-1722 ◽  
Author(s):  
Patrick Borges
Keyword(s):  
Cervical Cancer ◽  
Em Algorithm ◽  
Regression Model ◽  
Survival Data ◽  
Likelihood Estimation ◽  
Uterine Cervical Cancer ◽  
Cancer Data ◽  
Long Term Survivors

scholarly journals A BAYESIAN WEIBULL ANALYSIS OF BREAST CANCER DATA WITH LONG-TERM SURVIVORS IN PARANA STATE, BRAZIL

2021 ◽  
Vol 39 (2) ◽  
pp. 293-310
Author(s):  
Talita Evelin Nabarrete Tristão de MORAES ◽  
Isolde PREVIDELLI ◽  
Giovani Loiola da SILVA
Keyword(s):  
Breast Cancer ◽  
Survival Data ◽  
White Women ◽  
Age Groups ◽  
Population Based ◽  
Breast Cancer Data ◽  
Weibull Regression ◽  
Cancer Data ◽  
Long Term Survivors

Breast cancer is one of the most common diseases among women worldwide with about 25% of new cases each year. In Brazil, 59,700 new cases of breast cancer were expected in 2019, according to the Brazilian National Cancer Institute (INCA). Survival analysis has been an useful tool for the identifying the risk and prognostic factors for cancer patients. This work aims to characterize the prognostic value of demographic, clinical and pathological variables in relation to the survival time of 2,092 patients diagnosed with breast cancer in Parana State, Brazil, from 2004 to 2016. In this sense, we propose a Bayesian analysis of survival data with long-term survivors by using Weibull regression models through integrated nested Laplace approximations (INLA). The results point to a proportion of long-term survivors around 57:6% in the population under study. In regard to potential risk factors, we namely concluded that 40-50 year age group has superior survival than younger and older age groups, white women have higher breast cancer risk than other races, and marital status decreases that risk. Caution on the general use of these results is nevertheless advised, since we have analyzed population-based breast cancer data without proper monitoring by a healthprofessional.

scholarly journals Nadarajah-Haghighi Model for Survival Data With Long Term Survivors in the Presence of Right Censored Data

2021 ◽  
pp. 695-709
Author(s):  
Umar Usman ◽  
Shamsuddeen Suleiman ◽  
Bello Magaji Arkilla ◽  
Yakubu Aliyu
Keyword(s):  
Survival Data ◽  
Likelihood Estimation ◽  
Estimation Procedure ◽  
Right Censoring ◽  
Right Censored Data ◽  
Term Survival ◽  
Proposed Model ◽  
Cure Fraction ◽  
Long Term Survivors

In this paper, a new long term survival model called Nadarajah-Haghighi model for survival data with long term survivors was proposed. The model is used in fitting data where the population of interest is a mixture of individuals that are susceptible to the event of interest and individuals that are not susceptible to the event of interest. The statistical properties of the proposed model including quantile function, moments, mean and variance were provided. Maximum likelihood estimation procedure was used to estimate the parameters of the model assuming right censoring. Furthermore, Bayesian method of estimation was also employed in estimating the parameters of the model assuming right censoring. Simulations study was performed in order to ascertain the performances of the MLE estimators. Random samples of different sample sizes were generated from the model with some arbitrary values for the parameters for 5%, 1:3% and 1:5% cure fraction values. Bias, standard error and mean square error were used as discrimination criteria. Additionally, we compared the performance of the proposed model with some competing models. The results of the applications indicates that the proposed model is more efficient than the models compared with. Finally, we fitted some models considering type of treatment as a covariate. It was observed that the covariate  have effect on the shape parameter of the proposed model.

scholarly journals Treatment complications among long-term survivors of cervical cancer: treated by surgery or radiotherapy

2011 ◽  
Vol 5 (4) ◽  
pp. 261
Author(s):  
Kamal A. Elghamrawi ◽  
Mamdouh H. Haggag ◽  
Emmad E. Habib
Keyword(s):  
Cervical Cancer ◽  
Treatment Protocol ◽  
Bowel Dysfunction ◽  
Cervix Uteri ◽  
Bowel Habit ◽  
P Value ◽  
Patients Âgés ◽  
Age Related ◽  
Long Term Survivors

This study assesses the morbidity and complications of treatment among long-term survivors of cervical cancer. Ninety-eight female patients who were diagnosed and treated from invasive carcinoma of the cervix uteri 5 years or more are included in this study. All the cases were free of disease and had survived up to December 2010. Forty-one cases were treated with radical hysterectomy with removal of the lymph nodes (Wertheim’s surgery) (42%). Radical radiation therapy was given to 57 cases (58%) according to our treatment protocol; weekly cisplatin was given concomitantly with radiation. Although urinary adverse effects were more prevalent among the radiation group, the difference was not statistically significant. Bowel dysfunction was more prevalent and statistically significant (p\0.001) among the radiotherapy arm. Dysfunctions recorded included change in bowel habit, diarrhea, constipation, tenesmus, soiling of clothes and or flatulence. However, their severity was grade 1–2 only. The frequency of small intestinal obstruction was comparable in both arms. Pelvic vein thromboses had a tendency to occur among the surgical group especially in obese females (p value 0.005). The frequency of sexual dysfunction was comparable in both groups with no statistical difference. It was age related. The younger the patients’ ages, the more was the sexual complaint irrespective to the treatment modality. Sexual problems included dyspareunia from vaginal stenosis shortening or dryness, vulval soreness from itching and dryness. Bearing in mind that many patients had more than one health complaint. The remaining cases denied the presence of any complications and stated that they had a normal life style.

scholarly journals Treatment complications among long-term survivors of cervical cancer: treated by surgery or radiotherapy

2011 ◽  
Author(s):  
Kamal A. Elghamrawi ◽  
Mamdouh H. Haggag ◽  
Emmad E. Habib
Keyword(s):  
Cervical Cancer ◽  
Treatment Protocol ◽  
Bowel Dysfunction ◽  
Cervix Uteri ◽  
Bowel Habit ◽  
P Value ◽  
Patients Âgés ◽  
Age Related ◽  
Long Term Survivors

This study assesses the morbidity and complications of treatment among long-term survivors of cervical cancer. Ninety-eight female patients who were diagnosed and treated from invasive carcinoma of the cervix uteri 5 years or more are included in this study. All the cases were free of disease and had survived up to December 2010. Forty-one cases were treated with radical hysterectomy with removal of the lymph nodes (Wertheim’s surgery) (42%). Radical radiation therapy was given to 57 cases (58%) according to our treatment protocol; weekly cisplatin was given concomitantly with radiation. Although urinary adverse effects were more prevalent among the radiation group, the difference was not statistically significant. Bowel dysfunction was more prevalent and statistically significant (p\0.001) among the radiotherapy arm. Dysfunctions recorded included change in bowel habit, diarrhea, constipation, tenesmus, soiling of clothes and or flatulence. However, their severity was grade 1–2 only. The frequency of small intestinal obstruction was comparable in both arms. Pelvic vein thromboses had a tendency to occur among the surgical group especially in obese females (p value 0.005). The frequency of sexual dysfunction was comparable in both groups with no statistical difference. It was age related. The younger the patients’ ages, the more was the sexual complaint irrespective to the treatment modality. Sexual problems included dyspareunia from vaginal stenosis shortening or dryness, vulval soreness from itching and dryness. Bearing in mind that many patients had more than one health complaint. The remaining cases denied the presence of any complications and stated that they had a normal life style.

Long‐term evaluation of renal function and neurogenic bladder following radical hysterectomy in patients with uterine cervical cancer

2020 ◽  
Vol 46 (10) ◽  
pp. 2108-2114
Author(s):  
Hiroaki Komatsu ◽  
Tetsuro Oishi ◽  
Daiken Osaku ◽  
Akiko Kudoh ◽  
Ruri Shimogai ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Renal Function ◽  
Neurogenic Bladder ◽  
Radical Hysterectomy ◽  
Uterine Cervical Cancer ◽  
Term Evaluation

scholarly journals Characteristics of long‐term survivors with multiple myeloma: A National Cancer Data Base analysis

Cancer ◽  
2019 ◽  
Vol 125 (20) ◽  
pp. 3574-3581
Author(s):  
Ronan W. Hsieh ◽  
Ronald S. Go ◽  
Jithma P. Abeykoon ◽  
Prashant Kapoor ◽  
Shaji K. Kumar ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Data Base ◽  
National Cancer Data Base ◽  
Cancer Data ◽  
Base Analysis ◽  
Long Term Survivors

Data Quality in Rare Cancers Registration: The Report of the RARECARE Data Quality Study

2016 ◽  
Vol 103 (1) ◽  
pp. 22-32 ◽  
Author(s):  
Annalisa Trama ◽  
Rafael Marcos-Gragera ◽  
Maria Josè Sánchez Pérez ◽  
Jan Maarten van der Zwan ◽  
Eva Ardanaz ◽  
...  
Keyword(s):  
Oral Cavity ◽  
Data Quality ◽  
Germ Cell Tumors ◽  
Endocrine Tumors ◽  
Cancer Data ◽  
Rare Cancers ◽  
Common Cancer ◽  
Long Term Survivors

Purpose Rare cancers represent 22% of all tumors in Europe; however, the quality of the data of rare cancers may not be as good as the quality of data for common cancer. The project surveillance of rare cancers in Europe (RARECARE) had, among others, the objective of assessing rare cancer data quality in population-based cancer registries (CRs). Eight rare cancers were considered: mesothelioma, liver angiosarcoma, sarcomas, tumors of oral cavity, CNS tumors, germ cell tumors, leukemia, and malignant digestive endocrine tumors. Methods We selected data on 18,000 diagnoses and revised, on the basis of the pathologic and clinical reports (but not on pathologic specimens), unspecified morphology and topography codes originally attributed by CR officers and checked the quality of follow-up of long-term survivors of poor prognosis cancers. Results A total of 38 CRs contributed from 13 European countries. The majority of unspecified morphology and topography cases were confirmed as unspecified. The few unspecified cases that, after the review, changed to a more specific diagnosis increased the incidence of the common cancer histotypes. For example, 11% of the oral cavity epithelial cancers were reclassified from unspecified to more specific diagnoses: 8% were reclassified as squamous cell carcinoma (commoner) and only 1% as adenocarcinoma (rarer). The revision confirmed the majority of long-term survivors revealing a relative high proportion of mesothelioma long-term survivors. The majority of appendix carcinoids changed behavior from malignant to borderline lesions. Conclusions Our study suggests that the problem of poorly specified morphology and topography cases is mainly one of difficulty in reaching a precise diagnosis. The awareness of the importance of data quality for rare cancers should increase among registrars, pathologists, and clinicians.

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