Enantioselective Separation of Racemic Amlodipine by Two-Phase Chiral Extraction ContainingO,O′-Dibenzoyl-(2S,3S)-Tartaric Acid as Chiral Selector

2013 ◽  
Vol 48 (15) ◽  
pp. 2363-2371 ◽  
Author(s):  
Niti Sunsandee ◽  
Ura Pancharoen ◽  
Paitoon Rashatasakhon ◽  
Prakorn Ramakul ◽  
Natchanun Leepipatpiboon
Keyword(s):  
Tartaric Acid ◽  
Chiral Selector ◽  
Enantioselective Separation ◽  
Two Phase ◽  
Chiral Extraction

scholarly journals Enantioselective Extraction of Phenylalanine Enantiomers Using Environmentally Friendly Aqueous Two-Phase Systems

Processes ◽  
2018 ◽  
Vol 6 (11) ◽  
pp. 212 ◽  
Author(s):  
Danyu Sun ◽  
Runping Wang ◽  
Fenfang Li ◽  
Lianglei Liu ◽  
Zhijian Tan
Keyword(s):  
Ionic Liquids ◽  
Environmentally Friendly ◽  
Deep Eutectic Solvents ◽  
Chiral Selector ◽  
Extraction Temperature ◽  
Two Phase ◽  
Aqueous Two Phase Systems ◽  
Enantioselective Extraction ◽  
Chiral Extraction ◽  
Phase Systems

(1) Background: The environmentally friendly choline-amino acid ionic liquids (ChAAILs) and deep eutectic solvents (DESs) have been used as excellent alternatives to volatile organic compounds (VOCs) and ionic liquids (ILs) in recent years; (2) Methods: Thus, ChAAILs/salt and DESs/salt aqueous two-phase systems (ATPSs) were developed for the chiral extraction of phenylalanine enantiomers. The optimum ATPS of [Ch][L-Pro]/K3PO4 was chosen, and the influencing parameters were investigated, including ChAAILs concentration, salt concentration, chiral selector concentration, extraction temperature, phenylalanine concentration, and system pH; (3) Results: The phenylalanine enantiomers were mainly extracted into the top phase (ChAAIL-rich phase), meanwhile, the (S)-phenylalanine [(S)-Phe)] was preferentially recognized by the chiral selector in the top phase. The maximum separation factor (α) of 2.05 was obtained under the optimal conditions; and (4) Conclusions: This ATPS that was used for the chiral extraction of enantiomers is much more environmentally friendly, simple, and rapid, and has the potential to be used in the enantioselective extraction of other enantiomers.

Enantioselective separation of phenylglycidates by capillary electrophoresis employing sulfated β-cyclodextrin as chiral selector

2007 ◽  
Vol 850 (1-2) ◽  
pp. 560-563 ◽  
Author(s):  
Jianjun Wang ◽  
Qipeng Yuan ◽  
David G. Evans ◽  
Liu Yang ◽  
Guojun Zheng ◽  
...  
Keyword(s):  
Capillary Electrophoresis ◽  
Chiral Selector ◽  
Enantioselective Separation

Enantioselective separation of R,S-phenylsuccinic acid by biphasic recognition chiral extraction

2009 ◽  
Vol 64 (18) ◽  
pp. 4081-4088 ◽  
Author(s):  
Kewen Tang ◽  
Jianmin Yi ◽  
Yongbing Liu ◽  
Xinyu Jiang ◽  
Yang Pan
Keyword(s):  
Enantioselective Separation ◽  
Phenylsuccinic Acid ◽  
Chiral Extraction

Biphasic Enantioselective Partitioning of R,S-Omeprazole Enantiomers Using Chiral Extraction

2014 ◽  
Vol 1030-1032 ◽  
pp. 2334-2339
Author(s):  
Yan Liang Li ◽  
Zhong Zhen Liu ◽  
Yu Fen Huang ◽  
Lan Wei ◽  
Lian Xi Huang ◽  
...  
Keyword(s):  
Tartaric Acid ◽  
Organic Phase ◽  
Separation Factor ◽  
Extraction Efficiency ◽  
Distribution Coefficients ◽  
Variable Parameters ◽  
Chiral Selectors ◽  
Tartaric Acid Derivatives ◽  
Hexyl Ester ◽  
Chiral Extraction

Enantioselective partitioning of racemic omeprazole enantiomers was studied using a biphasic recognition chiral extraction system. Hydrophilic hydroxypropyl-ڂ-cyclodextrin in aqueous phase and hydrophobic D-tartaric acid hexyl ester in organic phase as chiral selectors which preferentially recognize (R)-omeprazole enantiomer and (S)-omeprazole enantiomer, respectively. Different experimental variable parameters could affect the chiral extraction efficiency. The largest distribution coefficientskS,kRand separation factorځwere obtained at concentrations o f 0.1 mol/L HP-ڂ-CD and 0.2 mol/L D-tartaric acid hexyl ester, which were 47.38, 58.65 and 1.24, respectively.kRis always larger thankSwhen using different kinds of tartaric acid derivatives as chiral selectors in organic phase. The present study also reveal the mechanism of biphasic recognition chiral extraction forR,S-omeprazole enantiomers.

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