Anterior thalamic nuclei deep brain stimulation reduces disruption of the blood–brain barrier, albumin extravasation, inflammation and apoptosis in kainic acid-induced epileptic rats

2017 ◽  
Vol 39 (12) ◽  
pp. 1103-1113 ◽  
Author(s):  
Ying-Chuan Chen ◽  
Guan-Yu Zhu ◽  
Xiu Wang ◽  
Lin Shi ◽  
Ting-Ting Du ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Kainic Acid ◽  
Blood Brain Barrier ◽  
Brain Stimulation ◽  
Brain Barrier ◽  
Thalamic Nuclei ◽  
Blood Brain ◽  
Anterior Thalamic Nuclei ◽  
Deep Brain

Headache Perception in an Epilepsy Patient with Neuromodulation by Anterior Thalamic Nuclei Deep Brain Stimulation: A Case Report

2020 ◽  
Vol 81 (04) ◽  
pp. 368-371
Author(s):  
Bogdan Pintea ◽  
Rainer Surges ◽  
Jan Boström
Keyword(s):  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Chronic Headache ◽  
Pain Perception ◽  
Focal Epilepsy ◽  
Thalamic Nuclei ◽  
Pain Anxiety ◽  
Anterior Thalamic Nuclei ◽  
Pain Anxiety Symptoms Scale ◽  
Deep Brain

Abstract Objective Headache disorders are frequently associated with epilepsy. Some neuromodulation techniques for refractory epilepsy have been reported to positively influence the associated chronic headache. However, the exact mechanism of action of vagus nerve stimulation (VNS) and anterior thalamic nuclei-deep brain stimulation (ANT-DBS) on pain perception is unclear. Method We report a structured assessment of pain perception in a patient who experienced headache relief after ANT-DBS for refractory focal epilepsy and compare it with pain perception of epilepsy patients with chronic headache who were treated with and without VNS. Results The pain-associated symptoms in the ANT-DBS case were on the Pain Anxiety Symptoms Scale (PASS-40) subscore “physiological anxiety” closer to the control collective, whereas in patients with VNS, this was more likely for the PASS-40 subscores “cognitive anxiety” or “escape and avoidance.” Conclusion ANT-DBS and VNS may influence epilepsy-associated chronic headache in different ways.

Effects of anterior thalamic nuclei deep brain stimulation on neurogenesis in epileptic and healthy rats

2017 ◽  
Vol 1672 ◽  
pp. 65-72 ◽  
Author(s):  
Ying-Chuan Chen ◽  
Lin Shi ◽  
Guan-Yu Zhu ◽  
Xiu Wang ◽  
De-feng Liu ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Thalamic Nuclei ◽  
Anterior Thalamic Nuclei ◽  
Deep Brain

scholarly journals High-fidelity transmission of high-frequency burst stimuli from peripheral nerve to thalamic nuclei in children with dystonia

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Estefanía Hernandez-Martin ◽  
Enrique Arguelles ◽  
Yifei Zheng ◽  
Ruta Deshpande ◽  
Terence D. Sanger
Keyword(s):  
Deep Brain Stimulation ◽  
Peripheral Nerve ◽  
Brain Stimulation ◽  
High Frequency ◽  
Sensory Information ◽  
Brain Structures ◽  
High Fidelity ◽  
Thalamic Nuclei ◽  
Frequency Burst ◽  
Deep Brain

AbstractHigh-frequency peripheral nerve stimulation has emerged as a noninvasive alternative to thalamic deep brain stimulation for some patients with essential tremor. It is not known whether such techniques might be effective for movement disorders in children, nor is the mechanism and transmission of the peripheral stimuli to central brain structures understood. This study was designed to investigate the fidelity of transmission from peripheral nerves to thalamic nuclei in children with dystonia undergoing deep brain stimulation surgery. The ventralis intermediate (VIM) thalamus nuclei showed a robust evoked response to peripheral high-frequency burst stimulation, with a greatest response magnitude to intra-burst frequencies between 50 and 100 Hz, and reliable but smaller responses up to 170 Hz. The earliest response occurred at 12–15 ms following stimulation onset, suggesting rapid high-fidelity transmission between peripheral nerve and thalamic nuclei. A high-bandwidth, low-latency transmission path from peripheral nerve to VIM thalamus is consistent with the importance of rapid and accurate sensory information for the control of coordination and movement via the cerebello-thalamo-cortical pathway. Our results suggest the possibility of non-invasive modulation of thalamic activity in children with dystonia, and therefore the possibility that a subset of children could have beneficial clinical response without the need for invasive deep brain stimulation.

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