Evaluation of the antiparkinsonism and neuroprotective effects of hydrogen sulfide in acute 6-hydroxydopamine-induced animal model of Parkinson’s disease: behavioral, histological and biochemical studies

2018 ◽  
Vol 40 (7) ◽  
pp. 525-533 ◽  
Author(s):  
Mohammad Sarukhani ◽  
Hashem Haghdoost-Yazdi ◽  
Ali Sarbazi Golezari ◽  
Arvin Babayan-Tazehkand ◽  
Tahere Dargahi ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Animal Model ◽  
Hydrogen Sulfide ◽  
Neuroprotective Effects ◽  
Biochemical Studies ◽  
6 Hydroxydopamine

Sex dimorphisms in the neuroprotective effects of estrogen in an animal model of Parkinson's disease

2004 ◽  
Vol 78 (3) ◽  
pp. 513-522 ◽  
Author(s):  
Glenda E Gillies ◽  
Hilary E Murray ◽  
David Dexter ◽  
Simon McArthur
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Animal Model ◽  
Neuroprotective Effects

scholarly journals Effects of Hypericum perforatum on turning behavior in an animal model of Parkinson's disease

2015 ◽  
Vol 51 (1) ◽  
pp. 111-115 ◽  
Author(s):  
Débora Dalla Vecchia ◽  
Marissa Giovanna Schamne ◽  
Marcelo Machado Ferro ◽  
Ana Flávia Chaves dos Santos ◽  
Camila Lupepsa Latyki ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Animal Model ◽  
Hypericum Perforatum ◽  
Neurodegenerative Disorder ◽  
Neuroprotective Effect ◽  
Turning Behavior ◽  
Age Related ◽  
Lesion Side ◽  
6 Hydroxydopamine

Parkinson's disease (PD) is an age-related neurodegenerative disorder characterized by the slow and progressive death of dopaminergic neurons in the (substantia nigra pars compact). Hypericum perforatum (H. perforatum) is a plant widely used as an antidepressant, that also presents antioxidant and anti-inflammatory properties. We evaluated the effects of H. perforatum on the turning behavior of rats submitted to a unilateral administration of 6-hydroxydopamine (6-OHDA) into the medial forebrain bundle as an animal model of PD. The animals were treated with H. perforatum (100, 200, or 400 mg/kg, v.o.) for 35 consecutive days (from the 28th day before surgery to the 7th day after). The turning behavior was evaluated at 7, 14 and 21 days after the surgery, and the turnings were counted as contralateral or ipsilateral to the lesion side. All tested doses significantly reduced the number of contralateral turns in all days of evaluation, suggesting a neuroprotective effect. However, they were not able to prevent the 6-OHDA-induced decrease of tyrosine hydroxylase expression in the lesioned striatum. We propose that H. perforatum may counteract the overexpression of dopamine receptors on the lesioned striatum as a possible mechanism for this effect. The present findings provide new evidence that H. perforatum may represent a promising therapeutic tool for PD.

Physical training exerts neuroprotective effects in the regulation of neurochemical factors in an animal model of Parkinson’s disease

Neuroscience ◽  
2012 ◽  
Vol 227 ◽  
pp. 305-312 ◽  
Author(s):  
T. Tuon ◽  
S.S. Valvassori ◽  
J. LOPES-BORGES ◽  
T. Luciano ◽  
C.B. Trom ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Animal Model ◽  
Physical Training ◽  
Neuroprotective Effects
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