The Effects of Ad Libitum Feeding and Marked Dietary Restriction on Spontaneous Skeletal Muscle Pathology in Sprague–Dawley Rats

2005 ◽  
Vol 33 (5) ◽  
pp. 600-608 ◽  
Author(s):  
Sylvain Molon-Noblot ◽  
Marie-Françoise Hubert ◽  
Chao-Min Hoe ◽  
Kevin Keenan ◽  
Philippe Laroque
Keyword(s):  
Skeletal Muscle ◽  
Dietary Restriction ◽  
Muscle Pathology ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
Ad Libitum ◽  
Ad Libitum Feeding

Circadian rhythm of serum and lymph apolipoprotein AIV in ad libitum-fed and fasted rats

1994 ◽  
Vol 267 (5) ◽  
pp. R1385-R1390 ◽  
Author(s):  
K. Fukagawa ◽  
H. M. Gou ◽  
R. Wolf ◽  
P. Tso
Keyword(s):  
Circadian Rhythm ◽  
Important Determinant ◽  
Lymph Flow ◽  
Right Atrial ◽  
Sprague Dawley ◽  
Mesenteric Lymph ◽  
Sprague Dawley Rats ◽  
Ad Libitum ◽  
Ad Libitum Feeding ◽  
Fasted Rats

The aim of the present study was to determine if there is a circadian rhythm in serum and lymph apolipoprotein (apo) AIV and what factors determine this rhythm. Male Sprague-Dawley rats with chronic right atrial catheter were housed in a room illuminated from 0600 to 1800. With ad libitum feeding, serum apo AIV concentration showed a circadian rhythm concomitant with the feeding pattern. In 24-h fasted rats, the serum apo AIV concentration maintained a circadian rhythm and was high during the dark. With mesenteric lymph diversion, serum apo AIV concentration diminished and the circadian rhythm was abolished. The lymph flow, lymph apo AIV, cholesterol, triacylglycerol, and phospholipid contents all exhibited the same circadian rhythm in fasting, with the levels higher in the dark. These circadian rhythms were abolished after bile diversion. In conclusion, serum apo AIV in ad libitum-fed and fasted rats exhibits a circadian rhythm governed by lymph apo AIV output. Furthermore, bile was an important determinant of the circadian rhythm of lymph flow, lymph apo AIV, triacylglycerol, cholesterol, and phospholipid output.

The Effects of Ad Libitum Overfeeding and Moderate and Marked Dietary Restriction on Age-Related Spontaneous Pituitary Gland Pathology in Sprague—Dawley Rats

2003 ◽  
Vol 31 (3) ◽  
pp. 310-320 ◽  
Author(s):  
Sylvain Molon-Noblot ◽  
Philippe Laroque ◽  
John B. Coleman ◽  
Chao-Min Hoe ◽  
Kevin P. Keenan
Keyword(s):  
Pituitary Gland ◽  
Dietary Restriction ◽  
Sprague Dawley ◽  
Age Related ◽  
Sprague Dawley Rats ◽  
Ad Libitum

The Effects of Ad Libitum Overfeeding and Moderate and Marked Dietary Restriction on Age-Related Spontaneous Pituitary Gland Pathology in Sprague-Dawley Rats

2003 ◽  
Vol 31 (3) ◽  
pp. 310-320 ◽  
Author(s):  
Sylvain Molon-Noblot ◽  
Philippe Laroque ◽  
John B. Coleman ◽  
Chao-Min Hoe ◽  
Kevin P. Keenan
Keyword(s):  
Pituitary Gland ◽  
Dietary Restriction ◽  
Sprague Dawley ◽  
Age Related ◽  
Sprague Dawley Rats ◽  
Ad Libitum

scholarly journals In utero glucocorticoid exposure reduces fetal skeletal muscle mass in rats independent of effects on maternal nutrition

2012 ◽  
Vol 302 (10) ◽  
pp. R1143-R1152 ◽  
Author(s):  
Ganga Gokulakrishnan ◽  
Irma J. Estrada ◽  
Horacio A. Sosa ◽  
Marta L. Fiorotto
Keyword(s):  
Skeletal Muscle ◽  
Food Intake ◽  
Maternal Nutrition ◽  
Muscle Protein ◽  
Fetal Liver ◽  
Muscle Growth ◽  
Tyrosine Aminotransferase ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
Ad Libitum

Maternal stress and undernutrition can occur together and expose the fetus to high glucocorticoid (GLC) levels during this vulnerable period. To determine the consequences of GLC exposure on fetal skeletal muscle independently of maternal food intake, groups of timed-pregnant Sprague-Dawley rats ( n = 7/group) were studied: ad libitum food intake (control, CON); ad libitum food intake with 1 mg dexamethasone/l drinking water from embryonic day (ED)13 to ED21 (DEX); pair-fed (PF) to DEX from ED13 to ED21. On ED22, dams were injected with [3H]phenylalanine for measurements of fetal leg muscle and diaphragm fractional protein synthesis rates (FSR). Fetal muscles were analyzed for protein and RNA contents, [3H]phenylalanine incorporation, and MuRF1 and atrogin-1 (MAFbx) mRNA expression. Fetal liver tyrosine aminotransferase (TAT) expression was quantified to assess fetal exposure to GLCs. DEX treatment reduced maternal food intake by 13% ( P < 0.001) and significantly reduced placental mass relative to CON and PF dams. Liver TAT expression was elevated only in DEX fetuses ( P < 0.01). DEX muscle protein masses were 56% and 70% than those of CON ( P < 0.01) and PF ( P < 0.05) fetuses, respectively; PF muscles were 80% of CON ( P < 0.01). Muscle FSR decreased by 35% in DEX fetuses ( P < 0.001) but were not different between PF and CON. Only atrogin-1 expression was increased in DEX fetus muscles. We conclude that high maternal GLC levels and inadequate maternal food intake impair fetal skeletal muscle growth, most likely through different mechanisms. When combined, the effects of decreased maternal intake and maternal GLC intake on fetal muscle growth are additive.

scholarly journals The Effects of Ad Libitum Overfeeding and Moderate and Marked Dietary Restriction on Age-Related Spontaneous Pancreatic Islet Pathology in Sprague—Dawley Rats

2001 ◽  
Vol 29 (3) ◽  
pp. 353-362 ◽  
Author(s):  
Sylvain Molon-Noblot ◽  
Kevin P. Keenan ◽  
John B. Coleman ◽  
Chao-Min Hoe ◽  
Philippe Laroque
Keyword(s):  
Pancreatic Islet ◽  
Dietary Restriction ◽  
Sprague Dawley ◽  
Age Related ◽  
Sprague Dawley Rats ◽  
Ad Libitum

Light and electron microscopic investigation of adenohypophyses of germfree, food-restricted, and germfree-food restricted aging, male lobund-wistar rats

1988 ◽  
Vol 46 ◽  
pp. 352-353
Author(s):  
G. Ilse ◽  
K. Kovacs ◽  
N. Ryan ◽  
T. Sano ◽  
L. Stefaneanu ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Microscopic Investigation ◽  
Electron Microscopic Investigation ◽  
Aging Male ◽  
Sprague Dawley ◽  
Electron Microscopic ◽  
Sprague Dawley Rats ◽  
Old Rats ◽  
Ad Libitum ◽  
Microscopic Findings

Germfree state and food restriction have been shown to increase life span and delay tumor occurrence in rats. We report here the histologic, immunocytochemical and electron microscopic findings of adenohypophyses of aging, male Lobund-Wistar rats raised at Lobund Laboratories. In our previous study, the morphologic changes in the adenohypophyses of old rats have been extensively investigated by histology, immunocytochemistry and electron microscopy. Lactotroph adenomas were frequent in Long-Evans and Sprague-Dawley rats, whereas gonadotroph adenomas were frequent in Sprague-Dawley and Wistar rats.Male Lobund-Wistar rats were divided into four groups: 1) conventional, which were raised under normal non-germfree environment and received food ad libitum; 2) germfree-food ad libitum; 3) conventional environment-food restricted and 4) germfree-food restricted. The adenohypophyses were removed from 6-month-, 18-month- and 30-month-old rats. For light microscopy, adenohypophyses were fixed in formalin and embedded in paraffin.

Effect of low-potassium diet on rat exercise hyperthermia and heatstroke mortality

1981 ◽  
Vol 51 (1) ◽  
pp. 8-13 ◽  
Author(s):  
R. W. Hubbard ◽  
M. Mager ◽  
W. D. Bowers ◽  
I. Leav ◽  
G. Angoff ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Body Weight ◽  
Plasma Potassium ◽  
Heat Illness ◽  
Sprague Dawley ◽  
Heat Gain ◽  
Sprague Dawley Rats ◽  
Low Potassium ◽  
Work Done ◽  
Low K

A total of 182 male Sprague-Dawley rats weighing 250–300 g were fed either a control (n = 122) diet for 32 days. The diets contained either 125 or 8 meq potassium/kg, respectively. Rats fed the low-K diet gained weight at only one-third the rate of controls (1.7 vs. 5.2 g/day), and their skeletal muscle and plasma potassium levels were reduced by 28 and 47%, respectively. When run to exhaustion at either 15 or 20 degrees C, low K+-fed rats accomplished less than one-half of the work done by the controls (26 vs. 53 kg. m) but exhibited a markedly greater rate of heat gain per kilogram-meter of work than controls (0.12 vs. 0.05 degrees C)ambient temperature of 20 degrees C, the rats of the low-K+ group despite large differences in body weight (-25%), run time temperature and twice (33 vs 17%) the mortality rate of the controls. Postexercise increases in circulating potassium (less than 90%) of heat-injured rats raised the plasma levels of low K+-fed rats to normal (5.9 +/- 2.2 meq/l). These results appear to characterize the existence of an insidious and, therefore, undocumented form of fatal exertion-induced heat illness.

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