Circadian rhythm of serum and lymph apolipoprotein AIV in ad libitum-fed and fasted rats

1994 ◽  
Vol 267 (5) ◽  
pp. R1385-R1390 ◽  
Author(s):  
K. Fukagawa ◽  
H. M. Gou ◽  
R. Wolf ◽  
P. Tso
Keyword(s):  
Circadian Rhythm ◽  
Important Determinant ◽  
Lymph Flow ◽  
Right Atrial ◽  
Sprague Dawley ◽  
Mesenteric Lymph ◽  
Sprague Dawley Rats ◽  
Ad Libitum ◽  
Ad Libitum Feeding ◽  
Fasted Rats

The aim of the present study was to determine if there is a circadian rhythm in serum and lymph apolipoprotein (apo) AIV and what factors determine this rhythm. Male Sprague-Dawley rats with chronic right atrial catheter were housed in a room illuminated from 0600 to 1800. With ad libitum feeding, serum apo AIV concentration showed a circadian rhythm concomitant with the feeding pattern. In 24-h fasted rats, the serum apo AIV concentration maintained a circadian rhythm and was high during the dark. With mesenteric lymph diversion, serum apo AIV concentration diminished and the circadian rhythm was abolished. The lymph flow, lymph apo AIV, cholesterol, triacylglycerol, and phospholipid contents all exhibited the same circadian rhythm in fasting, with the levels higher in the dark. These circadian rhythms were abolished after bile diversion. In conclusion, serum apo AIV in ad libitum-fed and fasted rats exhibits a circadian rhythm governed by lymph apo AIV output. Furthermore, bile was an important determinant of the circadian rhythm of lymph flow, lymph apo AIV, triacylglycerol, cholesterol, and phospholipid output.

The Effects of Ad Libitum Feeding and Marked Dietary Restriction on Spontaneous Skeletal Muscle Pathology in Sprague–Dawley Rats

2005 ◽  
Vol 33 (5) ◽  
pp. 600-608 ◽  
Author(s):  
Sylvain Molon-Noblot ◽  
Marie-Françoise Hubert ◽  
Chao-Min Hoe ◽  
Kevin Keenan ◽  
Philippe Laroque
Keyword(s):  
Skeletal Muscle ◽  
Dietary Restriction ◽  
Muscle Pathology ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
Ad Libitum ◽  
Ad Libitum Feeding

Light and electron microscopic investigation of adenohypophyses of germfree, food-restricted, and germfree-food restricted aging, male lobund-wistar rats

1988 ◽  
Vol 46 ◽  
pp. 352-353
Author(s):  
G. Ilse ◽  
K. Kovacs ◽  
N. Ryan ◽  
T. Sano ◽  
L. Stefaneanu ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Microscopic Investigation ◽  
Electron Microscopic Investigation ◽  
Aging Male ◽  
Sprague Dawley ◽  
Electron Microscopic ◽  
Sprague Dawley Rats ◽  
Old Rats ◽  
Ad Libitum ◽  
Microscopic Findings

Germfree state and food restriction have been shown to increase life span and delay tumor occurrence in rats. We report here the histologic, immunocytochemical and electron microscopic findings of adenohypophyses of aging, male Lobund-Wistar rats raised at Lobund Laboratories. In our previous study, the morphologic changes in the adenohypophyses of old rats have been extensively investigated by histology, immunocytochemistry and electron microscopy. Lactotroph adenomas were frequent in Long-Evans and Sprague-Dawley rats, whereas gonadotroph adenomas were frequent in Sprague-Dawley and Wistar rats.Male Lobund-Wistar rats were divided into four groups: 1) conventional, which were raised under normal non-germfree environment and received food ad libitum; 2) germfree-food ad libitum; 3) conventional environment-food restricted and 4) germfree-food restricted. The adenohypophyses were removed from 6-month-, 18-month- and 30-month-old rats. For light microscopy, adenohypophyses were fixed in formalin and embedded in paraffin.

Circadian rhythms of acid and bicarbonate efflux in fasting rat stomach

1991 ◽  
Vol 260 (4) ◽  
pp. G610-G614 ◽  
Author(s):  
K. R. Larsen ◽  
J. G. Moore ◽  
M. T. Dayton
Keyword(s):  
Circadian Rhythms ◽  
Test Solution ◽  
Circadian Rhythmicity ◽  
Sprague Dawley ◽  
Rat Stomach ◽  
Cosinor Analysis ◽  
Sprague Dawley Rats ◽  
Gastric Lumen ◽  
Sampling Times ◽  
Fasted Rats

One model of gastric ulcerogenesis implicates a disruption of complementary circadian rhythms between protective and destructive factors. The purpose of this study was to compare circadian rhythms in gastric production of H+ and HCO3- in fasted rats. Sprague-Dawley rats were acclimatized in sound-attenuating, light-proof chambers for 3 wk on a 12:12-h light-dark schedule. Eighteen-hour fasted rats were studied at each of eight sampling times. After anesthesia, the stomachs were cannulated and filled with test solution. Thirty-minute gastric samples were titrated for H+ or assayed for HCO3-. Cosinor analysis of the data showed significant (P less than 0.05) circadian rhythms for both H+ and HCO3-. Peak times were 22:45 HALO (hours after lights on) (4:45 A.M.) for H+ and 05:41 HALO (11:41 A.M.) for HCO3-. These data demonstrate that H+ and HCO3- secretion in the fasting rat gastric lumen follow circadian rhythms with different peak times. Theoretically, this may result in circadian rhythmicity of relative mucosal vulnerability to injury.

Glutamine promotes triglyceride absorption in a dose-dependent manner

2002 ◽  
Vol 282 (2) ◽  
pp. G317-G323 ◽  
Author(s):  
Jeffrey B. Schwimmer ◽  
Looi Ee ◽  
Shuqin Zheng ◽  
Patrick Tso
Keyword(s):  
Amino Acid ◽  
Amino Acid Mixture ◽  
Lipid Absorption ◽  
Acid Mixture ◽  
Dependent Manner ◽  
Sprague Dawley ◽  
Feeding Tubes ◽  
Mesenteric Lymph ◽  
Sprague Dawley Rats ◽  
Dose Dependent

Dietary proteins may play a role in lipid absorption. Whether amino acids are specifically involved is unknown. We hypothesized that enterally administered l-glutamine (l-Gln) given with a lipid meal increases triglyceride (TG) absorption in rats. Mesenteric lymph fistulae and gastroduodenal feeding tubes were placed in adult male Sprague-Dawley rats. The animals received an enteral bolus of Intralipid (5 ml) followed by enteral infusion of increasing concentrations of l-Gln in saline (0, 85, 170, or 340 mM) or equimolar concentrations of the inactive isomer d-Gln or an essential amino acid mixture without Gln. Lymph was collected continuously for 6 h and analyzed for TG content. Animals infused with 85 mM l-Gln had a 64% increase in total TG output vs. controls ( P < 0.05) despite no difference in lymph flow rate. Total TG output for animals infused with 340 mMl-Gln declined by 43% vs. controls ( P < 0.05). The effect of Gln in promoting lymphatic fat transport is specific to l-Gln and not shared by d-Gln or an equivalent amino acid mixture. l-Gln is capable of either promoting or impairing lymphatic TG transport in a dose-dependent manner.

scholarly journals Chronic Nephropathy in Ad Libitum Overfed Sprague-Dawley Rats and Its Early Attenuation by Increasing Degrees of Dietary (Caloric) Restriction to Control Growth

2000 ◽  
Vol 28 (6) ◽  
pp. 788-798 ◽  
Author(s):  
Kevin P. Keenan ◽  
John B. Coleman ◽  
Carol L. Mccoy ◽  
Chao-Min Hoe ◽  
Keith A. Soper ◽  
...  
Keyword(s):  
Caloric Restriction ◽  
Sprague Dawley ◽  
Chronic Nephropathy ◽  
Sprague Dawley Rats ◽  
Control Growth ◽  
Ad Libitum

The Effects of Ad Libitum Overfeeding and Moderate and Marked Dietary Restriction on Age-Related Spontaneous Pituitary Gland Pathology in Sprague—Dawley Rats

2003 ◽  
Vol 31 (3) ◽  
pp. 310-320 ◽  
Author(s):  
Sylvain Molon-Noblot ◽  
Philippe Laroque ◽  
John B. Coleman ◽  
Chao-Min Hoe ◽  
Kevin P. Keenan
Keyword(s):  
Pituitary Gland ◽  
Dietary Restriction ◽  
Sprague Dawley ◽  
Age Related ◽  
Sprague Dawley Rats ◽  
Ad Libitum

Latency to Leave an Elevated Platform, Activity in a Dark Chamber, and Weight in Aging Sprague-Dawley Rats

1975 ◽  
Vol 36 (1) ◽  
pp. 231-236 ◽  
Author(s):  
C. I. Thompson ◽  
Thomas R. Fitzsimons
Keyword(s):  
Young Adult ◽  
Young Adulthood ◽  
Learning Ability ◽  
Sprague Dawley ◽  
Age Changes ◽  
Dark Chamber ◽  
Memory Research ◽  
Sprague Dawley Rats ◽  
Ad Libitum ◽  
Step Down

Young adult, middle-aged, and old male Sprague-Dawley rats ( n = 42) were compared for differences in step-down latency and activity in a darkened chamber. Ad libitum weights also were recorded. Latencies to leave a step-down platform increased about 400% from 4 to 9 mo. and then stabilized, suggesting that performance in this apparatus, commonly used in memory research, is very sensitive to age changes in rats less than 1 yr. old. Activity in the darkened chamber continued to decrease linearly from young adulthood to senility. Thus decreases in activity with age follow differing slopes, depending upon the task. Ad libitum weights increased linearly from 5 to 22.5 mo. A possible methodological implication for between-age comparisons of learning ability motivated by food was noted.

scholarly journals Differential Effects of Long-Term Caloric Restriction and Dietary Protein Source on Bone and Marrow Fat of the Aging Rat

2020 ◽  
Vol 75 (11) ◽  
pp. 2031-2036 ◽  
Author(s):  
Gustavo Duque ◽  
Ahmed Al Saedi ◽  
Daniel Rivas ◽  
Stéphanie Miard ◽  
Guylaine Ferland ◽  
...  
Keyword(s):  
Caloric Restriction ◽  
Bone Quality ◽  
Tissue Expression ◽  
Sprague Dawley ◽  
Marrow Fat ◽  
Differential Effects ◽  
Sprague Dawley Rats ◽  
Negative Effect ◽  
Ad Libitum

Abstract Long-term caloric restriction (CR) has been shown to be beneficial to various tissues and organs. In contrast, CR exerts differential effects on bone, which could be due in part to the nature of the protein regime utilized. Male Sprague Dawley rats (8-month-old) were subjected for 12 months to 40% CR in macronutrients and compared with rats fed ad libitum for the same period. Casein- and soy-fed groups were compared. There was a significant decrease in bone quality in both CR groups, which was independent of the source of protein in the diet. In contrast, the group fed soy protein ad libitum showed better bone quality and higher levels of bone formation compared with casein-fed animals. Notably, bone marrow adipocytes were not mobilized upon CR as demonstrated by an absence of change in adipocyte number and tissue expression of leptin. This study demonstrates that the negative effect of CR on bone quality could not be prevented by the most common protein regimes.

Suppression of food intake, body weight, and body fat by jejunal fatty acid infusions

2000 ◽  
Vol 278 (3) ◽  
pp. R604-R610 ◽  
Author(s):  
James E. Cox ◽  
William J. Tyler ◽  
Alan Randich ◽  
Gary R. Kelm ◽  
Satinder S. Bharaj ◽  
...  
Keyword(s):  
Body Weight ◽  
Oleic Acid ◽  
Linoleic Acid ◽  
Caloric Intake ◽  
Sprague Dawley ◽  
Total Load ◽  
Total Intake ◽  
Sprague Dawley Rats ◽  
Saline Administration ◽  
Ad Libitum

Three experiments investigated effects of jejunal lipid infusions given on 4 or 21 consecutive days in adult, male Sprague-Dawley rats. In experiment 1, 7-h infusions of linoleic or oleic acid (0.2 ml/h for 7 h; total load = 11.5 kcal) on 4 consecutive days reduced total intake (ad libitum consumption of the liquid diet Boost, Mead Johnson, plus load) by ∼15% and decreased weight gain compared with 4-day tests with saline administration. In experiment 2, linoleic acid at 0.1 ml/h for 7 h (5.7 kcal) was ineffective, whereas the same load delivered in 3.5 h produced effects similar in magnitude to those in the first experiment. In experiment 3, jejunal infusions of linoleic acid (0.2 ml/h for 7 h) on 21 consecutive days reduced mean total intake by 16%, body weight by 10%, and carcass fat by 48% compared with controls receiving saline. The net decrease in caloric intake may reflect the combined activation of pre- and postabsorptive mechanisms, and it suggests a possible treatment for obesity.

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