Fat embolism syndrome is one of the many complications in traumatology, which carries a serious danger due to the difficult diagnosis at the early stages of its development. In many medical sources, fat embolism syndrome is described as a severe condition characterized by obturation of blood vessels by embolus, which are represented by fat droplets larger than 7-9 microns. Fat embolism is usually caused by trauma, accompanied by crushing of tissues. This is especially common in fractures of the tubular bones as a result of high-energy trauma. As exemplified in the medical literature about 6-7 % of isolated fractures and 37 % of combined injuries lead to the appearance of fat embolism syndrome. Much more often, fat embolism develops in open fractures, and the frequency of its occurrence increases with a combination of open and closed fractures. Due to the fact that fat embolism is a life-threatening condition, early detection of this pathology is necessary. The purpose of this literature review is to study the pathogenesis of fat embolism, as well as the possibilities, problems and methods of early diagnosis of this pathology in trauma practice...