The impact of comorbidities on survival in oral cancer patients: a population-based, case-control study

2020 ◽  
pp. 1-7
Author(s):  
Mustafa Ghanizada ◽  
Kathrine Kronberg Jakobsen ◽  
Jakob Schmidt Jensen ◽  
Irene Wessel ◽  
Jesper Filtenborg Tvedskov ◽  
...  
Author(s):  
VivekM Tarsariya ◽  
Nilesh Raval ◽  
DhavalN Mehta ◽  
MukeshK Asrani ◽  
VijayK Asrani ◽  
...  

2021 ◽  
Vol 9 ◽  
Author(s):  
Baochang He ◽  
Jing Wang ◽  
Jing Lin ◽  
Jinfa Chen ◽  
Zhaocheng Zhuang ◽  
...  

Cerium (Ce), the most abundant of rare earth elements in the earth's crust, has received much health concerns due to its wide application in industry, agriculture, and medicine. The current study aims to evaluate whether there is an association between Ce exposures and the risk of developing oral cancer. Serum Ce level of 324 oral cancer patients and 650 matched healthy controls were measured by inductively coupled plasma mass spectrometry. Association between Ce level and the risk of oral cancer was estimated with an unconditional logistic regression model. Serum Ce concentrations in the oral cancer patients and controls were 0.57 (0.21–3.02) μg/L and 2.27 (0.72–4.26) μg/L, respectively. High level of Ce was associated with a decreased risk of oral cancer (OR: 0.60, 95% CI: 0.43–0.84). Stronger inverse associations between high level of Ce and oral cancer risk were observed among those with smoking (OR: 0.46, 95% CI: 0.27–0.79), drinking (OR: 0.50, 95% CI: 0.26–0.96), limited intake of leafy vegetables (OR: 0.40, 95% CI: 0.22–0.71) and fish (OR: 0.52, 95% CI: 0.33–0.83). There were significant multiplicative interactions between Ce level and alcohol drinking or intake of leafy vegetables and fish (all Pinteraction <0.05). This preliminary case-control study suggests an inverse association between high serum Ce level and the risk of oral cancer. Further prospective studies with a larger sample size are needed to confirm the findings.


2014 ◽  
Vol 4 (1) ◽  
pp. 4-7
Author(s):  
SA Urmi ◽  
I Zerin ◽  
MSA Farzan ◽  
MA Kabir

DOI: http://dx.doi.org/10.3329/bjdre.v4i1.18008 Bangladesh Journal of Dental Research & Education Vol.4(1) 2014: 4-7


2016 ◽  
Vol 139 ◽  
pp. 29-37 ◽  
Author(s):  
Aneel A. Ashrani ◽  
Rachel E. Gullerud ◽  
Tanya M. Petterson ◽  
Randolph S. Marks ◽  
Kent R. Bailey ◽  
...  

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
C. Airoldi ◽  
C. Magnani ◽  
F. Lazzarato ◽  
D. Mirabelli ◽  
S. Tunesi ◽  
...  

Abstract Background Neighborhood exposure to asbestos increases the risk of developing malignant mesothelioma (MM) in residents who live near asbestos mines and asbestos product plants. The area of Casale Monferrato (Northwest Italy) was impacted by several sources of asbestos environmental pollution, due to the presence of the largest Italian asbestos cement (AC) plant. In the present study, we examined the spatial variation of MM risk in an area with high levels of asbestos pollution and secondly, and we explored the pattern of clustering. Methods A population-based case–control study conducted between 2001 and 2006 included 200 cases and 348 controls. Demographic and occupational data along with residential information were recorded. Bivariate Kernel density estimation was used to map spatial variation in disease risk while an adjusted logistic model was applied to estimate the impact of residential distance from the AC plant. Kulldorf test and Cuzick Edward test were then performed. Results One hundred ninety-six cases and 322 controls were included in the analyses. The contour plot of the cases to controls ratio showed a well-defined peak of MM incidence near the AC factory, and the risk decreased monotonically in all directions when large bandwidths were used. However, considering narrower smoothing parameters, several peaks of increased risk were reported. A constant trend of decreasing OR with increasing distance was observed, with estimates of 10.9 (95% CI 5.32–22.38) and 10.48 (95%CI 4.54–24.2) for 0–5 km and 5–10 km, respectively (reference > 15 km). Finally, a significant (p < 0.0001) excess of cases near the pollution source was identified and cases are spatially clustered relative to the controls until 13 nearest neighbors. Conclusions In this study, we found an increasing pattern of mesothelioma risk in the area around a big AC factory and we detected secondary clusters of cases due to local exposure points, possibly associated to the use of asbestos materials.


2005 ◽  
Vol 36 (2) ◽  
pp. 106-107 ◽  
Author(s):  
Jennie Borg ◽  
Deborah Christie ◽  
Pietro Coen ◽  
Robert Booy ◽  
Russell Viner

Author(s):  
Mark Elwood

This chapter shows a large population-based case-control study, to address the quantitative relationship between alcohol consumption and breast cancer. It shows the logistic and design issues, and the assessment of dose-response, consistency and specificity. The critical assessment follows the scheme set out in chapter 10: describing the study, assessing the non-causal explanations of observation bias, confounding, and chance variation; assessing time relationships, strength, dose-response, consistency and specificity, and applying the results to the eligible, source, and target populations; and then comparing the results with evidence from other studies, considering consistency and specificity, biological mechanisms, and coherence with the distribution of exposures and outcomes. The chapter gives a summary and table of the critical assessment and its conclusions; and comments on the impact of the study and research carried out since.


Oral Oncology ◽  
2019 ◽  
Vol 96 ◽  
pp. 1-6 ◽  
Author(s):  
Christian Grønhøj ◽  
Kathrine Kronberg Jakobsen ◽  
Eva Kjær ◽  
Jeppe Friborg ◽  
Christian von Buchwald

2008 ◽  
Vol 15 (6) ◽  
pp. 372-382 ◽  
Author(s):  
Sarah Polack ◽  
Hannah Kuper ◽  
Cristina Eusebio ◽  
Wanjiku Mathenge ◽  
Zakia Wadud ◽  
...  

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