Ocular Permeability of Pirenzepine Hydrochloride Enhanced by Methoxy poly(ethylene glycol)–poly(D,L-lactide) Block Copolymer

2007 ◽  
Vol 33 (10) ◽  
pp. 1142-1150 ◽  
Author(s):  
Jiasheng Tu ◽  
Hui Pang ◽  
Zhen Yan ◽  
Pengmei Li
Keyword(s):  
Block Copolymer ◽  
Ethylene Glycol ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

scholarly journals Local Toxicity of Topically Administrated Thermoresponsive Systems: In Vitro Studies with In Vivo Correlation

2018 ◽  
Vol 47 (3) ◽  
pp. 426-432 ◽  
Author(s):  
Sivan Yogev ◽  
Ayelet Shabtay-Orbach ◽  
Abraham Nyska ◽  
Boaz Mizrahi
Keyword(s):  
Block Copolymer ◽  
Ethylene Glycol ◽  
Medical Devices ◽  
Poly Lactic Acid ◽  
Poly Ethylene Glycol ◽  
Thermoresponsive Polymers ◽  
Wide Range ◽  
Poly Ethylene

Thermoresponsive materials have the ability to respond to a small change in temperature—a property that makes them useful in a wide range of applications and medical devices. Although very promising, there is only little conclusive data about the cytotoxicity and tissue toxicity of these materials. This work studied the biocompatibility of three Food and Drug Administration approved thermoresponsive polymers: poly( N-isopropyl acrylamide), poly(ethylene glycol)-poly(propylene glycol)-poly(ethylene glycol) tri-block copolymer, and poly(lactic acid-co-glycolic acid) and poly(ethylene glycol) tri-block copolymer. Fibroblast NIH 3T3 and HaCaT keratinocyte cells were used for the cytotoxicity testing and a mouse model for the in vivo evaluation. In vivo results generally showed similar trends as the results seen in vitro, with all tested materials presenting a satisfactory biocompatibility in vivo. pNIPAM, however, showed the highest toxicity both in vitro and in vivo, which was explained by the release of harmful monomers and impurities. More data focusing on the biocompatibility of novel thermoresponsive biomaterials will facilitate the use of existing and future medical devices.

Star-shaped poly(l-lactide)-b-poly(ethylene glycol) with porphyrin core: synthesis, self-assembly, drug-release behavior and singlet oxygen research

2014 ◽  
Vol 38 (8) ◽  
pp. 3569-3578 ◽  
Author(s):  
Xiao-Hui Dai ◽  
Zhi-Ming Wang ◽  
Lu-You Gao ◽  
Jian-Ming Pan ◽  
Xiao-Hong Wang ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Block Copolymer ◽  
Drug Release ◽  
Ethylene Glycol ◽  
Self Assembly ◽  
Release Behavior ◽  
Poly Ethylene Glycol ◽  
Drug Release Behavior ◽  
Porphyrin Core ◽  
Poly Ethylene

pH-induced block copolymer SPPLA-b-PEG with porphyrin core for photodynamic therapy.

In SituSynthesis of Block Copolymer Nanoassemblies via Polymerization-Induced Self-Assembly in Poly(ethylene glycol)

2016 ◽  
Vol 49 (10) ◽  
pp. 3789-3798 ◽  
Author(s):  
Chengqiang Gao ◽  
Heng Zhou ◽  
Yaqing Qu ◽  
Wei Wang ◽  
Habib Khan ◽  
...  
Keyword(s):  
Block Copolymer ◽  
Ethylene Glycol ◽  
Self Assembly ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene
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