Biodegradable thermo-sensitive nanoparticles from poly(l-lactic acid)/poly(ethylene glycol) alternating multi-block copolymer for potential anti-cancer drug carrier

2006 ◽  
Vol 27 (2-3) ◽  
pp. 115-122 ◽  
Author(s):  
Kun Na ◽  
Kwang Hee Lee ◽  
Don Haeng Lee ◽  
You Han Bae
Keyword(s):  
Lactic Acid ◽  
Block Copolymer ◽  
Ethylene Glycol ◽  
Drug Carrier ◽  
Cancer Drug ◽  
Poly Ethylene Glycol ◽  
Anti Cancer ◽  
Poly Ethylene

scholarly journals Assessing the Molecular Interaction between Poly Lactic-co-glycolic Acid (PLGA) 50:50 and Poly Ethylene Glycol in Presence of Diethyl Phthalate Using in silico Study - A Novel Approach of Pre-Formulation Study

2021 ◽  
pp. 144-150
Author(s):  
V. Senthil Kumar ◽  
Navabshan Irfan ◽  
T. V. Ajay Kumar ◽  
V. Parthasarathy
Keyword(s):  
Ethylene Glycol ◽  
In Silico ◽  
Glycolic Acid ◽  
Drug Carrier ◽  
Drug Formulation ◽  
Diethyl Phthalate ◽  
Cancer Drug ◽  
Poly Ethylene Glycol ◽  
Study Results ◽  
Poly Ethylene

The efficacy of a drug relies on drug formulation and targeting. Imatinib is an anti-cancer drug identified to be effective in the treatment of cancers like myeloid leukemia and lymphoblastic leukemia, and gastrointestinal tumors. The prediction of mixing energy and identification of docking interactions and scores can help identify the most efficient drug carrier/plasticizer molecule that could exert maximum pharmaceutical efficiency. The results of a preliminary study explicitly showed the potent carrier molecule before conducting formulation studies. Hence, the present study was designed to screen the interaction energies between different combinations of Poly (lactic-co-glycolic acid) (PGLA) or Poly Ethylene Glycol (PEG) or diethyl phthalate with Imatinib using in silico computational methods. The study results suggested that the binding energy and the score obtained for docking interactions for Imatinib versus diethyl phthalate was better when compared to the other combinations. Therefore, Diethyl phthalate might be a signature candidate to act as Imatinib-carrier/plasticizer. More formulation studies are warranted further to demonstrate the desired continuous drug release and maximum efficacy with Imatinib chemotherapy.

NiFe2O4/poly(ethylene glycol)/lipid–polymer hybrid nanoparticles for anti-cancer drug delivery

2020 ◽  
Vol 44 (42) ◽  
pp. 18162-18172
Author(s):  
K. S. Joshy ◽  
Robin Augustine ◽  
Anshida Mayeen ◽  
Susan M. Alex ◽  
Anwarul Hasan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ethylene Glycol ◽  
Nickel Ferrite ◽  
Hybrid Nanoparticles ◽  
Cancer Drug ◽  
Poly Ethylene Glycol ◽  
Polymer Hybrid ◽  
Anti Cancer ◽  
Poly Ethylene ◽  
Cancer Drug Delivery

The present study reports the fabrication of hybrid nanoparticles consisting of nickel ferrite (NFO) for anti cancer drug delivery.

Poly(lactic acid)/poly(ethylene glycol) block copolymer based shell or core cross-linked micelles for controlled release of hydrophobic drug

RSC Advances ◽  
2015 ◽  
Vol 5 (25) ◽  
pp. 19484-19492 ◽  
Author(s):  
Junjie Li ◽  
Shuangzhuang Guo ◽  
Min Wang ◽  
Lei Ye ◽  
Fanglian Yao
Keyword(s):  
Lactic Acid ◽  
Block Copolymer ◽  
Ethylene Glycol ◽  
Poly Lactic Acid ◽  
Release Behavior ◽  
Hydrophobic Drug ◽  
Poly Ethylene Glycol ◽  
Block Copolymer Micelles ◽  
Copolymer Micelles ◽  
Poly Ethylene

The syntheses, structures, and drug release behavior of shell or core cross-linked poly(lactic acid)/poly(ethylene glycol) block copolymer micelles.

scholarly journals Synthesis and Characterization of Star-Shaped Block Copolymer sPCL-b-PEG-GA

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Yi Zhang ◽  
Qian Zhao ◽  
Hewei Shao ◽  
Shiyu Zhang ◽  
Xiaoyan Han
Keyword(s):  
Molecular Weight ◽  
Block Copolymer ◽  
Ethylene Glycol ◽  
Condensation Reaction ◽  
Drug Carrier ◽  
Drug Loading ◽  
Glycyrrhetinic Acid ◽  
Glycyrrhetic Acid ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

Compared to linear polymers with the same molecular weight, star-shaped polymers have the superiority of drug loading and delivery. The glycyrrhetinic acid (GA) from licorice is remarkably characteristic of liver distribution and liver cells targetability. In this paper, four-armed star-shaped polycaprolactone was synthesized and amino polyethylene glycol was modified by glycyrrhetinic acid (NH2-PEG-GA). Then the condensation reaction between the two above polymers finally produced four-armed star-shaped poly(ethylene glycol)-b-poly(ε-caprolactone) block copolymer (sPCL-b-PEG-GA). The structures of the intermediates and product were characterized by1H NMR. The results indicated that the structure and molecular weight of sPCL-b-PEG-GA can be controlled by the varied ratios of pentaerythritol (PTOL) toε-caprolactone (ε-CL) in the presence of stannous octoate (Sn(Oct)2), and the amphiphilic copolymer sPCL-b-PEG-GA consists of PTOL as core, PCL as inner hydrophobic segments, PEG as external hydrophilic segments, and terminal glycyrrhetic acid as targeting ligand. The work explored a new synthesis route of star poly(ethylene glycol)-b-poly(ε-caprolactone) copolymer with liver targetability. The star-shaped polymer is expected to be an efficient drug carrier.

Poly(ethylene glycol)-Based Polymer Carrier of Doxorubicin Degradable by Both Enzymatic and Chemical Hydrolyses

2005 ◽  
Vol 70 (3) ◽  
pp. 327-338 ◽  
Author(s):  
Michal Pechar ◽  
Alena Braunová ◽  
Karel Ulbrich
Keyword(s):  
Ethylene Glycol ◽  
Water Soluble ◽  
Cancer Drug ◽  
Poly Ethylene Glycol ◽  
Polymer Carrier ◽  
Chemical Hydrolysis ◽  
Anti Cancer ◽  
Hydrazide Derivative ◽  
Poly Ethylene

The synthesis and characterization of a water-soluble biodegradable multiblock polyurethane based on poly(ethylene glycol) blocks interconnected by a pentapeptide derivative N,N'-bis(aspartylprolyl)lysine is described. The pentapeptide linkages are susceptible both to chemical hydrolysis in neutral and mild acid medium (pH 5) and to enzymatic degradation by lysosomal enzyme cathepsin B. Anti-cancer drug doxorubicin was attached to a hydrazide derivative of the polymer via a hydrolytically labile hydrazone bond. Both the pH-triggered hydrolytic release of the drug and the degradation of the polymer carrier by enzymatic and chemical hydrolysis were studied using liquid chromatography.

Polymer micelles as novel drug carrier: Adriamycin-conjugated poly(ethylene glycol)-poly(aspartic acid) block copolymer

1990 ◽  
Vol 11 (1-3) ◽  
pp. 269-278 ◽  
Author(s):  
Yokoyama Masayuki ◽  
Miyauchi Mizue ◽  
Yamada Noriko ◽  
Okano Teruo ◽  
Sakurai Yasuhisa ◽  
...  
Keyword(s):  
Block Copolymer ◽  
Ethylene Glycol ◽  
Aspartic Acid ◽  
Drug Carrier ◽  
Polymer Micelles ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene ◽  
Novel Drug
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