PLGA Nanoparticles for the Oral Delivery of 5-Fluorouracil Using High Pressure Homogenization-Emulsification as the Preparation Method and In Vitro/In Vivo Studies

2008 ◽  
Vol 34 (1) ◽  
pp. 107-115 ◽  
Author(s):  
XueMing Li ◽  
YuanLong Xu ◽  
GuoGuang Chen ◽  
Ping Wei ◽  
QiNeng Ping
Keyword(s):  
High Pressure ◽  
Oral Delivery ◽  
Preparation Method ◽  
Plga Nanoparticles ◽  
In Vivo Studies ◽  
High Pressure Homogenization

scholarly journals PLGA nanoparticles for the oral delivery of nuciferine: preparation, physicochemical characterization and in vitro/in vivo studies

Drug Delivery ◽  
2017 ◽  
Vol 24 (1) ◽  
pp. 443-451 ◽  
Author(s):  
Ying Liu ◽  
Xin Wu ◽  
Yushuai Mi ◽  
Bimeng Zhang ◽  
Shengying Gu ◽  
...  
Keyword(s):  
Oral Delivery ◽  
Physicochemical Characterization ◽  
Plga Nanoparticles ◽  
In Vivo Studies

Biopharmaceutical and Preclinical Studies of Zaleplon as Semisolid Dispersions with Self-emulsifying Lipid Surfactants for Oral Delivery

1970 ◽  
Vol 9 (1) ◽  
pp. 3102-3111
Author(s):  
Narendar Dudhipala ◽  
Arjun Narala ◽  
Dinesh Suram ◽  
Karthik Yadav Janga
Keyword(s):  
Oral Delivery ◽  
Molecular State ◽  
In Vivo Studies ◽  
In Vitro Dissolution ◽  
Content Uniformity ◽  
Phase Solubility ◽  
Microscopic Studies ◽  
Pure Drug

The objective of this present study is to develop a semisolid dispersion (SSD) of zaleplon with the aid of self-emulsifying lipid based amphiphilic carriers (TPGS E or Gelucire 44/14) addressing the poor solubility of this drug. A linear relationship between the solubility of drug with respect to increase in the concentration of lipid surfactant in aqueous medium resulting in AL type phase diagram was observed from phase solubility studies. Fusion method was employed to obtain semisolid dispersions (SSD) of zaleplon which showed high content uniformity of drug. The absence of chemical interactions between the pure drug, excipients and formulations were conferred by Fourier transmission infrared spectroscopic examinations. The photographic images from polarized optical microscopic studies revealed the change in crystalline form of drug to amorphous or molecular state. The superior dissolution parameters of zaleplon from SSD over pure crystalline drug interpreted from in vitro dissolution studies envisage the ability of these lipid surfactants as solubility enhancers. Further, the caliber of TPGS E or Gelucire 44/14 in encouraging the GI absorption of drug was evident with the higher human effective permeability coefficient and fraction oral dose of drug absorbed from SSD in situ intestinal permeation study. In conclusion, in vivo studies in Wister rats demonstrated an improvement in the oral bioavailability of zaleplon from SSD over control pure drug suspension suggesting the competence of Gelucire 44/14 and TPGS E as conscientious carriers to augment the dissolution rate limited bioavailability of this active

Use of mPEG-PLGA nanoparticles to improve bioactivity and hemocompatibility of streptokinase: In-vitro and in-vivo studies

2021 ◽  
Vol 118 ◽  
pp. 111427
Author(s):  
Akram Hasanpour ◽  
Fariba Esmaeili ◽  
Hossein Hosseini ◽  
Amir Amani
Keyword(s):  
Plga Nanoparticles ◽  
In Vivo Studies

Oil based nanocarrier for improved oral delivery of silymarin: In vitro and in vivo studies

2011 ◽  
Vol 413 (1-2) ◽  
pp. 245-253 ◽  
Author(s):  
Rabea Parveen ◽  
Sanjula Baboota ◽  
Javed Ali ◽  
Alka Ahuja ◽  
Suruchi S. Vasudev ◽  
...  
Keyword(s):  
Oral Delivery ◽  
In Vivo Studies

Nanocarrier based formulation of Thymoquinone improves oral delivery: Stability assessment, in vitro and in vivo studies

2013 ◽  
Vol 102 ◽  
pp. 822-832 ◽  
Author(s):  
Anjali Singh ◽  
Iqbal Ahmad ◽  
Sohail Akhter ◽  
Gaurav K. Jain ◽  
Zeenat Iqbal ◽  
...  
Keyword(s):  
Oral Delivery ◽  
In Vivo Studies ◽  
Stability Assessment

Carbamazepine and levetiracetam-loaded PLGA nanoparticles prepared by nanoprecipitation method: in vitro and in vivo studies

2020 ◽  
Vol 46 (7) ◽  
pp. 1063-1072
Author(s):  
Busra Kandilli ◽  
Afife Busra Ugur Kaplan ◽  
Meltem Cetin ◽  
Numan Taspinar ◽  
Muhammed Sait Ertugrul ◽  
...  
Keyword(s):  
Plga Nanoparticles ◽  
In Vivo Studies ◽  
Nanoprecipitation Method

scholarly journals Garcinol loaded vitamin E TPGS emulsified PLGA nanoparticles: preparation, physicochemical characterization, in vitro and in vivo studies

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Raghuvir H. Gaonkar ◽  
Soumya Ganguly ◽  
Saikat Dewanjee ◽  
Samarendu Sinha ◽  
Amit Gupta ◽  
...  
Keyword(s):  
Vitamin E ◽  
Physicochemical Characterization ◽  
Plga Nanoparticles ◽  
In Vivo Studies ◽  
Vitamin E Tpgs

scholarly journals Monitoring the Fate of Orally Administered PLGA Nanoformulation for Local Delivery of Therapeutic Drugs

Pharmaceutics ◽  
2019 ◽  
Vol 11 (12) ◽  
pp. 658 ◽  
Author(s):  
Lucia Morelli ◽  
Sara Gimondi ◽  
Marta Sevieri ◽  
Lucia Salvioni ◽  
Maria Guizzetti ◽  
...  
Keyword(s):  
Oral Administration ◽  
Systemic Exposure ◽  
Plga Nanoparticles ◽  
In Vivo Studies ◽  
Cancer Drug ◽  
Therapeutic Drugs ◽  
Human Disorders ◽  
Carcinoma Colon

One of the goals of the pharmaceutical sciences is the amelioration of targeted drug delivery. In this context, nanocarrier-dependent transportation represents an ideal method for confronting a broad range of human disorders. In this study, we investigated the possibility of improving the selective release of the anti-cancer drug paclitaxel (PTX) in the gastro-intestinal tract by encapsulating it into the biodegradable nanoparticles made by FDA-approved poly(lactic-co-glycolic acid) (PLGA) and coated with polyethylene glycol to improve their stability (PLGA-PEG-NPs). Our study was performed by combining the synthesis and characterization of the nanodrug with in vivo studies of pharmacokinetics after oral administration in mice. Moreover, fluorescent PLGA-nanoparticles (NPs), were tested both in vitro and in vivo to observe their fate and biodistribution. Our study demonstrated that PLGA-NPs: (1) are stable in the gastric tract; (2) can easily penetrate inside carcinoma colon 2 (CaCo2) cells; (3) reduce the PTX absorption from the gastrointestinal tract, further limiting systemic exposure; (4) enable PTX local targeting. At present, the oral administration of biodegradable nanocarriers is limited because of stomach degradation and the sink effect played by the duodenum. Our findings, however, exhibit promising evidence towards our overcoming these limitations for a more specific and safer strategy against gastrointestinal disorders.

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