Carbamazepine and levetiracetam-loaded PLGA nanoparticles prepared by nanoprecipitation method: in vitro and in vivo studies

2020 ◽  
Vol 46 (7) ◽  
pp. 1063-1072
Author(s):  
Busra Kandilli ◽  
Afife Busra Ugur Kaplan ◽  
Meltem Cetin ◽  
Numan Taspinar ◽  
Muhammed Sait Ertugrul ◽  
...  
Keyword(s):  
Plga Nanoparticles ◽  
In Vivo Studies ◽  
Nanoprecipitation Method

Use of mPEG-PLGA nanoparticles to improve bioactivity and hemocompatibility of streptokinase: In-vitro and in-vivo studies

2021 ◽  
Vol 118 ◽  
pp. 111427
Author(s):  
Akram Hasanpour ◽  
Fariba Esmaeili ◽  
Hossein Hosseini ◽  
Amir Amani
Keyword(s):  
Plga Nanoparticles ◽  
In Vivo Studies

scholarly journals Garcinol loaded vitamin E TPGS emulsified PLGA nanoparticles: preparation, physicochemical characterization, in vitro and in vivo studies

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Raghuvir H. Gaonkar ◽  
Soumya Ganguly ◽  
Saikat Dewanjee ◽  
Samarendu Sinha ◽  
Amit Gupta ◽  
...  
Keyword(s):  
Vitamin E ◽  
Physicochemical Characterization ◽  
Plga Nanoparticles ◽  
In Vivo Studies ◽  
Vitamin E Tpgs

scholarly journals Monitoring the Fate of Orally Administered PLGA Nanoformulation for Local Delivery of Therapeutic Drugs

Pharmaceutics ◽  
2019 ◽  
Vol 11 (12) ◽  
pp. 658 ◽  
Author(s):  
Lucia Morelli ◽  
Sara Gimondi ◽  
Marta Sevieri ◽  
Lucia Salvioni ◽  
Maria Guizzetti ◽  
...  
Keyword(s):  
Oral Administration ◽  
Systemic Exposure ◽  
Plga Nanoparticles ◽  
In Vivo Studies ◽  
Cancer Drug ◽  
Therapeutic Drugs ◽  
Human Disorders ◽  
Carcinoma Colon

One of the goals of the pharmaceutical sciences is the amelioration of targeted drug delivery. In this context, nanocarrier-dependent transportation represents an ideal method for confronting a broad range of human disorders. In this study, we investigated the possibility of improving the selective release of the anti-cancer drug paclitaxel (PTX) in the gastro-intestinal tract by encapsulating it into the biodegradable nanoparticles made by FDA-approved poly(lactic-co-glycolic acid) (PLGA) and coated with polyethylene glycol to improve their stability (PLGA-PEG-NPs). Our study was performed by combining the synthesis and characterization of the nanodrug with in vivo studies of pharmacokinetics after oral administration in mice. Moreover, fluorescent PLGA-nanoparticles (NPs), were tested both in vitro and in vivo to observe their fate and biodistribution. Our study demonstrated that PLGA-NPs: (1) are stable in the gastric tract; (2) can easily penetrate inside carcinoma colon 2 (CaCo2) cells; (3) reduce the PTX absorption from the gastrointestinal tract, further limiting systemic exposure; (4) enable PTX local targeting. At present, the oral administration of biodegradable nanocarriers is limited because of stomach degradation and the sink effect played by the duodenum. Our findings, however, exhibit promising evidence towards our overcoming these limitations for a more specific and safer strategy against gastrointestinal disorders.

scholarly journals PLGA nanoparticles for the oral delivery of nuciferine: preparation, physicochemical characterization and in vitro/in vivo studies

Drug Delivery ◽  
2017 ◽  
Vol 24 (1) ◽  
pp. 443-451 ◽  
Author(s):  
Ying Liu ◽  
Xin Wu ◽  
Yushuai Mi ◽  
Bimeng Zhang ◽  
Shengying Gu ◽  
...  
Keyword(s):  
Oral Delivery ◽  
Physicochemical Characterization ◽  
Plga Nanoparticles ◽  
In Vivo Studies

scholarly journals IN-VITRO AND IN VIVO STUDIES OF CETUXIMAB LOADED POLYMERIC NANOPARTICLES

2018 ◽  
Vol 8 (5-s) ◽  
pp. 184-188 ◽  
Author(s):  
Ajinder Kaushik ◽  
Hemant Kumar Sharma
Keyword(s):  
Zeta Potential ◽  
Physicochemical Properties ◽  
Polymeric Nanoparticles ◽  
Plga Nanoparticles ◽  
In Vivo Studies ◽  
Biodegradable Nanoparticles

Nanoparticles speak to one of the appealing choices in the compelling treatment of tumor chemo-treatment. In the present work, definition and improvement of a novel Cetuximab (MTX)- stacked biodegradable nanoparticles utilizing poly(D,L-lactide-co-glycolide) (PLGA) was done. The arranged nanoparticles were assessed for physicochemical properties, for example, molecule measure, zeta potential, discharge thinks about, and so forth. Molecule size of upgraded definition was < 200 nm. Our essential outcomes exhibit that the created Cetuximab-stacked PLGA nanoparticles discharging the medication for delayed timeframe. Keywords: Cetuximab; PLGA 50:50; nanoparticles

scholarly journals Improved Controlled Release and Brain Penetration of the Small Molecule S14 Using PLGA Nanoparticles

2021 ◽  
Vol 22 (6) ◽  
pp. 3206
Author(s):  
Vanesa Nozal ◽  
Elisa Rojas-Prats ◽  
Inés Maestro ◽  
Carmen Gil ◽  
Daniel I. Perez ◽  
...  
Keyword(s):  
Controlled Release ◽  
Inflammatory Diseases ◽  
Polymeric Nanoparticles ◽  
Cyclic Adenosine Monophosphate ◽  
Adenosine Monophosphate ◽  
Plga Nanoparticles ◽  
In Vivo Studies ◽  
Drug Release Profile

Phosphodiesterase 7 (PDE7) is an enzyme responsible for the degradation of cyclic adenosine monophosphate (cAMP), an important cellular messenger. PDE7’s role in neurotransmission, expression profile in the brain and the druggability of other phosphodiesterases have motivated the search for potent inhibitors to treat neurodegenerative and inflammatory diseases. Different heterocyclic compounds have been described over the years; among them, phenyl-2-thioxo-(1H)-quinazolin-4-one, called S14, has shown very promising results in different in vitro and in vivo studies. Recently, polymeric nanoparticles have been used as new formulations to target specific organs and produce controlled release of certain drugs. In this work, we describe poly(lactic-co-glycolic acid) (PLGA)-based polymeric nanoparticles loaded with S14. Their preparation, optimization, characterization and in vivo drug release profile are here presented as an effort to improve pharmacokinetic properties of this interesting PDE7 inhibitor.

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