Hospitalization-induced exacerbation of the ill effects of chemotherapy on rest-activity rhythm and quality of life of breast cancer patients: a prospective and comparative cross-sectional follow-up study

Abstract Purpose To evaluate symptoms of late radiation toxicity, side effects, and quality of life in breast cancer patients treated with hyperbaric oxygen therapy (HBOT). Methods For this cohort study breast cancer patients treated with HBOT in 5 Dutch facilities were eligible for inclusion. Breast cancer patients with late radiation toxicity treated with ≥ 20 HBOT sessions from 2015 to 2019 were included. Breast and arm symptoms, pain, and quality of life were assessed by means of the EORTC QLQ-C30 and -BR23 before, immediately after, and 3 months after HBOT on a scale of 0–100. Determinants associated with persistent breast pain after HBOT were assessed. Results 1005/1280 patients were included for analysis. Pain scores decreased significantly from 43.4 before HBOT to 29.7 after 3 months (p < 0.001). Breast symptoms decreased significantly from 44.6 at baseline to 28.9 at 3 months follow-up (p < 0.001) and arm symptoms decreased significantly from 38.2 at baseline to 27.4 at 3 months follow-up (p < 0.001). All quality of life domains improved at the end of HBOT and after 3 months follow-up in comparison to baseline scores. Most prevalent side effects of HBOT were myopia (any grade, n = 576, 57.3%) and mild barotrauma (n = 179, 17.8%). Moderate/severe side effects were reported in 3.2% (n = 32) of the patients. Active smoking during HBOT and shorter time (i.e., median 17.5 vs. 22.0 months) since radiotherapy were associated with persistent breast pain after HBOT. Conclusion Breast cancer patients with late radiation toxicity reported reduced pain, breast and arm symptoms, and improved quality of life following treatment with HBOT.

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Factors associated with disease progression among hormone receptor-positive breast cancer patients treated with endocrine therapy: A 5-year cross-sectional, retrospective follow-up study

Journal of Applied Pharmaceutical Science ◽

10.7324/japs.2021.110107 ◽

2020 ◽

Author(s):

Rani Nurul Sahida ◽

Wahab Mohd Shahezwan Abd ◽

Zulkifly Hanis Hanum ◽

Mohamad Siti Hartinie

Keyword(s):

Breast Cancer ◽

Cancer Patients ◽

Hormone Receptor ◽

Breast Cancer Patients ◽

Cross Sectional ◽

Factors Associated ◽

Follow Up Study ◽

Hormone Receptor Positive ◽

Positive Breast Cancer

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Determination of the Influence of Peripheral Neuropathy Symptoms on Quality of Life in Breast Cancer Patients Receiving Paclitaxel: Prospective Cross Sectional Study With Four Follow-ups

10.21203/rs.3.rs-984164/v1 ◽

2021 ◽

Author(s):

BERNA KURT ◽

ZEYNEP SİPAHİ KARSLI ◽

BERNA ÖMÜR ÇAKMAK ÖKSÜZOĞLU ◽

EMİNE ÖZTÜRK ◽

NESLİHAN DEMİRÖRS ◽

...

Keyword(s):

Breast Cancer ◽

Quality Of Life ◽

Peripheral Neuropathy ◽

Assessment Tool ◽

Life Questionnaire ◽

Breast Cancer Patients ◽

Cross Sectional ◽

Quality Of Life Questionnaire

Abstract Background The objective of this study is to evaluate the impact of peripheral neuropathy on the quality of life of breast cancer patients throughout with monthly follow-up during 4 months of paclitaxel treatment.Material and methods The research was conducted with a prospective cross sectional with four follow-ups descriptive design. The study population consisted of female patients with breast cancer at Ankara Oncology Training and Research Hospital between August 2018 and January 2019. Data were collected the ‘’Patient Information Form’’,‘’EORTC C30 Cancer Quality Of Life Questionnaire’’ and ‘’Chemotherapy-Induced Peripheral Neuropathy Assessment Tool’’. The study was undertaken in accordance with the STROBE checklist for cross-sectional studies. Results Of 79 patients included in the Chemotherapy-Induced Peripheral Neuropathy Assessment Tool except for the general activity subdimension were statistically significant in the ratings of 2nd, compared to 1st; 3rd compared to 1st and 2nd; 4th compared to 1st, 2nd, and 3rd follow-up periods. The overall mean of EORTC C30 Cancer Quality of Life Questionnaire, functional subdimension, symptom severity, and general well-being in the evaluations of 2nd, compared with 1st; 3rd compared with 1st and 2nd; 4th compared with 1st, 2nd, and 3rd follow-up periods it was found that the mean values of symptom that decreased gradually were statistically significant.Conclusion The neuropathy scale was found to be higher in 2nd, 3rd, 4th follow-up periods than in 1st follow-up. Also, EORTC C30 Cancer QLQ subdimensions were high initially but gradually decreased after the fourth cycle. Thus, it was found that the increase in neuropathy symptoms negatively affects the quality of life.

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Prevalence of comorbidities and quality of life assessment among breast cancer patients at the Komfo Anokye Teaching Hospital: A descriptive cross-sectional study

10.5348/c01-2017-4-oa-1 ◽

2020 ◽

Keyword(s):

Breast Cancer ◽

Quality Of Life ◽

Cancer Patients ◽

Cross Sectional Study ◽

Life Assessment ◽

Breast Cancer Patients ◽

Sectional Study ◽

Quality Of Life Assessment ◽

Cross Sectional

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Quality of Life of Breast Cancer Patients in Amhara Region, Ethiopia: A Cross-Sectional Study

10.21203/rs.3.rs-122800/v1 ◽

2020 ◽

Author(s):

Tamrat Alem ◽

Dabere Nigatu ◽

Amsalu Birara ◽

Tamene Fetene ◽

Mastewal Giza

Keyword(s):

Breast Cancer ◽

Quality Of Life ◽

Cancer Patients ◽

Associated Factors ◽

Cross Sectional Study ◽

Breast Cancer Patients ◽

Sectional Study ◽

Amhara Region ◽

Cross Sectional

Abstract BackgroundAlthough breast cancer has a markedly higher incidence in developed countries, 50% of the new diagnosis and 70% of deaths occur in developing countries. There are limited data available on the quality of life among breast cancer patients in Ethiopia, notably in the Amhara region. This study aimed to assess the quality of life and associated factors among patients with breast cancer in the Amhara Region, Ethiopia, 2019.MethodsInstitutional based cross-sectional study was conducted from March 25 to July 7/2019 among 256 patients with breast cancer in the Amhara region. A systematic random sampling technique was used. Data were collected by using a standardized interviewer-administered Amharic version of the European Organization for research and treatment of cancer quality of life questionnaire core 30(EORTC QLQ C30) and breast cancer supplementary measure (QLQ-BR23). Data were analyzed by SPSS version 23. A binary logistic regression model was fitted to identify the associated factors. The odds ratio (OR) with 95% confidence interval (CI) was used to measure the strength of association.ResultsSixty-eight point four percent (68.4%) of breast cancer patient's QoL was poor. The mean score of quality of life was 70.6(standard deviation (SD) ±13.9; 95% CI: 69.0-72.4). All functional component scores were less than 75, from the symptom scale; diarrhea (11.6), constipation (17.5), and dyspnea (24.7) were less noticeable. Unmarried patients (AOR=2.59, 95% CI: 1.32-5.07), poor (AOR=2.39, 95%CI: 1.32-5.03), non housewife (AOR=3.25, 95% CI: 1.16-7.22), and complaints to dyspnea (AOR=3.48, 95% CI: 1.79-6.79), and insomnia (AOR=2.03, 95% CI: 1.05-3.91) were significantly associated with quality of life.ConclusionsHealth care professionals should give attention to unmarried, and non-housewife breast cancer patients, besides the treatment to improve the health of breast cancer patients.

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Effect of Inhibited T lymphocyte Function on Depressive Symptoms in Breast Cancer Patients with Depression

10.21203/rs.3.rs-967907/v1 ◽

2021 ◽

Author(s):

Jun-He Zhou ◽

Wei-Han Li ◽

De-Long Zhang ◽

Bai-Le Ning ◽

Lin Zhao ◽

...

Keyword(s):

Breast Cancer ◽

Quality Of Life ◽

T Lymphocytes ◽

Cancer Patients ◽

T Lymphocyte ◽

Structural Equations ◽

Lymphocyte Function ◽

Breast Cancer Patients ◽

Cross Sectional

Abstract Background: Depression has a high incidence among patients with breast cancer, but the relationship between depression and cancer-related physiological changes is not clear.Objectives: To explore the effect of T lymphocytes on breast cancer depression and the patient’s quality of life.Methods: This is a cross-sectional study. A total of 93 breast cancer patients with depression were recruited, 46 of whom underwent T lymphocyte, cortisol, BDNF, TNF-α, and IL-1β collection. We analysed the correlation between the indicators in these 46 participants and constructed two intermediary structural equations between their T lymphocytes and depression, as well as their T lymphocytes and their quality of life.Results: The results showed that CD4+ had a positive correlation with BDNF (r=0.334, P=0.023) and that BDNF had a negative correlation with HAMD-24 (r=-0.390, P=0.007). Both CD3+ and CD8+ cells were negatively correlated with cortisol (r=-0.358, P=0.015, r=-0.411, P=0.005), and cortisol was positively correlated with FACT-B (r=0.435, P=0.003). The equations including CD4+, BDNF, and HAMD-24, as well as the equations including CD3+, CD8+, cortisol, and FACT-B, were established. BDNF was the mediating variable between CD4+ and HAMD-24. Cortisol was the mediating variable between CD3+, CD8+ and FACT-B. Neither HAMD-24 nor FACT-B could form a direct path with T lymphocytes.Conclusion: T lymphocytes may be involved in the depression of breast cancer patients since a poor quality of life could inhibit T lymphocytes, and this may be the underlying physiological cause of breast cancer-related depression.

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