Corticotropin Releasing Hormone and Arginine Vasopressin Stimulation of Acth and Substance P in Human Mononuclear Leukocytes

SummaryStress-induced stimulation of corticotropic function involves the activation of hypothalamic corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP), which can be measured by improved methods of neuroendocrine investigation. The antiserotoninergic tricyclic antidepressant, tianeptine, reduces the corticotropic response to stress, as shown by a reduction in hypothalamo-hypophyseal portal CRH and AVP levels.

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Release of hypothalamic corticotropin-releasing hormone and arginine-vasopressin by interleukin 1β and αMSH: studies in rats with different susceptibility to inflammatory disease

Brain Research ◽

10.1016/0006-8993(93)91181-q ◽

1993 ◽

Vol 631 (1) ◽

pp. 22-26 ◽

Cited By ~ 29

Author(s):

Piotr Zelazowski ◽

Vladimir K. Patchev ◽

Elzbieta B. Zelazowska ◽

George P. Chrousos ◽

Philip W. Gold ◽

...

Keyword(s):

Arginine Vasopressin ◽

Inflammatory Disease ◽

Interleukin 1Β ◽

Corticotropin Releasing Hormone ◽

Releasing Hormone

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Brain oxytocin receptors mediate corticotropin-releasing hormone-induced anorexia

AJP Regulatory Integrative and Comparative Physiology ◽

10.1152/ajpregu.1991.260.2.r448 ◽

1991 ◽

Vol 260 (2) ◽

pp. R448-R452 ◽

Cited By ~ 13

Author(s):

B. R. Olson ◽

M. D. Drutarosky ◽

E. M. Stricker ◽

J. G. Verbalis

Keyword(s):

Food Intake ◽

Adrenocorticotropic Hormone ◽

Central Administration ◽

Corticotropin Releasing Hormone ◽

Releasing Hormone ◽

Oxytocin Receptors ◽

Artificial Cerebrospinal Fluid ◽

Pituitary Secretion ◽

Inhibit Food Intake ◽

Stimulation Of

Central administration of corticotropin-releasing hormone (CRH) is known to inhibit food intake and stimulate pituitary oxytocin (OT) secretion in rats. These experiments addressed the possibility that the inhibition of food intake that follows central CRH administration is mediated through oxytocinergic pathways. Male food-deprived rats, with stable baseline food intakes after intracerebroventricular (icv) injections of artificial cerebrospinal fluid, received 150 pmol of CRH icv. Food intake was inhibited by 62 +/- 5% during a 90-min test period. Pretreatment with 9 nmol of the OT antagonist [d(CH2)5, Tyr(Me)2, Orn8]vasotocin icv completely eliminated the inhibition of food intake produced by icv CRH. In contrast, pretreatment with the OT-receptor antagonist did not significantly alter pituitary secretion of adrenocorticotropic hormone and OT stimulated by icv CRH. The results of these experiments implicate OT as a possible central mediator of CRH-induced anorexias in rats, particularly those that are accompanied by stimulation of neurohypophysial OT secretion.

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Consistent Reduction of ACTH responses to stimulation with CRH, Vasopressin and Hypoglycaemia in Patients with Major Depression

The British Journal of Psychiatry ◽

10.1192/bjp.155.4.468 ◽

1989 ◽

Vol 155 (4) ◽

pp. 468-478 ◽

Cited By ~ 48

Author(s):

Roger G. Kathol ◽

Richard S. Jaeckle ◽

Juan F. Lopez ◽

William H. Meller

Keyword(s):

Major Depression ◽

Hpa Axis ◽

Negative Correlation ◽

Arginine Vasopressin ◽

Corticotropin Releasing Hormone ◽

Hypothalamic Pituitary Adrenal ◽

Releasing Hormone ◽

Control Subjects ◽

Basal Cortisol ◽

Cortisol Responses

Eleven patients with major depression and 12 control subjects were administered corticotropin-releasing hormone (CRH), aqueous arginine vasopressin (AVP), and insulin hypoglycaemia (IH) to test for differences in hypothalamic–pituitary–adrenal (HPA) axis function. Patients with major depression demonstrated lower ACTH responses to CRH when compared with controls, and a trend toward such after administration of AVP. Despite lower ACTH responses in patients with depression, there were no differences in Cortisol responses to these stimuli. In the CRH and AVP tests, there was no correlation between the basal Cortisol and ACTH responses in either controls or patients, but in the IH test there was a negative correlation between these responses for both groups. The ACTH responses to CRH and AVP were positively correlated in controls and patients. Cortisol responses to all three provocative stimuli were positively correlated in both subject groups. These findings are consistent with the hypothesis that hypothalamic or supra-hypothalamic overactivity may be involved in the development of HPA-axis abnormalities in patients with depression.

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