Using Genetic Algorithm and ELM Neural Networks for Feature Extraction and Classification of Type 2-Diabetes Mellitus

2018 ◽  
Vol 33 (4) ◽  
pp. 311-328 ◽  
Author(s):  
Abir Alharbi ◽  
Munirah Alghahtani
Author(s):  
Lívia Maria Lopes de OLIVEIRA ◽  
Lívia Mirelle BARBOSA

ABSTRACT Periodontal disease and type 2 diabetes mellitus are considered chronic diseases that at their core have a deep relationship with inflammation. It is assumed that there is a bidirectional relationship between periodontal disease and type 2 diabetes mellitus. It is estimated that approximately 10% of the world’s population is affected by periodontal disease, in its most severe form, almost the same percentage estimated for people with diabetes, which is considered a 21st century emergency. The World Workshop for the Classification of Periodontal and Peri-implant Diseases and Conditions took place from September 9-11, 2017. The aim of this study is to analyze the results of this workshop with regard to the relationship between periodontal diseases/conditions and diabetes mellitus, in addition to conducting an integrative review on the topic. A literature review was conducted, using the Medline electronic databases via Pubmed, Scientific Electronic Library Online, Scientific and Technical Literature of Latin America and the Caribbean and Virtual Health Library. A new classification of periodontal disease included tools for individual assessment of the patient and recognizing risk factors that might negatively interfere in response to treatment. The occurrence of metabolic lack of control in periodontal patients with type 2 diabetes mellitus is now considered a factor of great importance for the assessment of individual susceptibility to the progression of periodontitis. Diabetes is believed to promote a hyper inflammatory response to bacterial challenge by modifying the tissue response of periodontal tissues.


1987 ◽  
Vol 29 (3) ◽  
pp. 340-344
Author(s):  
Nobuo Matsuura ◽  
Kenji Fujieda ◽  
Yuhei Mikami ◽  
Hiroko Fujita ◽  
Shohei Harada ◽  
...  

1970 ◽  
Vol 1 (1) ◽  
pp. 1-6
Author(s):  
Hiroshi Bando ◽  
Yoshikane Kato ◽  
Setsuko Kanazawa ◽  
Mayumi Tanaka ◽  
Etsuko Sueki ◽  
...  

Authors have continued clinical research on type 2 diabetes mellitus (T2DM). The trigger of this research was to make notice of elevated HbA1c of younger male diabetics for hot climate in the summer 2018. Enrolled subjects were 89 male patients with T2DM. Methods include the classification of 6 groups by the age, which are 21-40, 41-50, 51-60, 61-70, 71-80 and 81-90. HbA1c values in median were calculated for five seasons of 15 months. Basal HbA1c in 6 groups was 7.0%, 7.1%, 7.2%, 7.2%, 6.9% and 7.0%, respectively. Seasonal changes in HbA1c values are as follows: i) groups 21-50 showed highest in the summer, ii) groups 51-70 showed gradually decrease from winter to summer, iii) groups 71-90 showed gradually decrease from winter to autumn, and increase for winter. For seasonal HbA1c changes, influence of hot climate during from spring to summer may be involved for 21-50 years. More activity in spring to summer may be related for 51-70 years. Less exercise and more eating may be observed for 71-90 years. There are not enough analyze for related factors, then further study concerning various biomarkers would be expected.


2021 ◽  
Vol 9 (1) ◽  
pp. 14-20
Author(s):  
S.Yu. Mogilevskyy ◽  
K.A. Hudzenko

Background. Numerous literature data made it possible to establish the dependence of primary open-angle glaucoma (POAG) in patients with diabetic retinopathy (DR) on type 2 diabetes mellitus (DM2). The purpose was to determine the prevalence and characteristics of primary open-angle glaucoma in patients with diabetic retinopathy in type 2 diabetes mellitus. Material and me­thods. One thousand four hundred and fifty patients with DM2 were examined, in whom the stage of DR was determined according to the classification of American Academy of Ophthalmology (2002). POAG stage was established according to the classification of A.P. Nesterov and A.Ya. Bunin (1976) and classification of perimetric changes by glaucoma stages. The age of patients, 970 (66.9 %) men and 480 (33.1 %) women, was from 45 to 75 years. The duration of DM2 was from 2 to 15 years. For statistical studies, MedStat and MedCalc v.15.1 (Medcalc Software bvba) were used. Results. In patients with DM2 and DR of different stages, the prevalence of POAG amounted to 20.8 %, which is 4–6 times higher than in the general population. Among individuals with DR stage I (no retinopathy), 71.6 % had POAG stage I and II, among patients with non-proliferative DR, 87.6 % had stages II and III, and among those with proliferative DR, 78.4 % had stages III and IV. Among all patients with DR and POAG, the proportion of normal tension glaucoma was 18.6 %, which did not differ from that in POAG without DM2. 42.9 % of patients initially had the development of DM2 in past medical history, joined by POAG in 1–7 years, and 57.1 % first had POAG, joined by DM2 in 1–8 years. Depending on the duration of the disease, the severity of both DR and POAG increased, which indicated the dependence of DR and POAG severity on disease duration and acceleration of their development if they combined. Conclusions. The results of the study confirmed the wider pre­valence and mutual burden of DR course in DM2 and POAG, which justifies the need to study the general mechanisms of their pathogenesis.


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