scholarly journals The relationship between periodontite and diabetes mellitus type ii facing the new classification of periodontal diseases: literature review

2020 ◽  
Vol 68 ◽  
Author(s):  
Lívia Maria Lopes de OLIVEIRA ◽  
Lívia Mirelle BARBOSA
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Literature Review ◽  
Periodontal Disease ◽  
Periodontal Diseases ◽  
New Classification ◽  
The Relationship

ABSTRACT Periodontal disease and type 2 diabetes mellitus are considered chronic diseases that at their core have a deep relationship with inflammation. It is assumed that there is a bidirectional relationship between periodontal disease and type 2 diabetes mellitus. It is estimated that approximately 10% of the world’s population is affected by periodontal disease, in its most severe form, almost the same percentage estimated for people with diabetes, which is considered a 21st century emergency. The World Workshop for the Classification of Periodontal and Peri-implant Diseases and Conditions took place from September 9-11, 2017. The aim of this study is to analyze the results of this workshop with regard to the relationship between periodontal diseases/conditions and diabetes mellitus, in addition to conducting an integrative review on the topic. A literature review was conducted, using the Medline electronic databases via Pubmed, Scientific Electronic Library Online, Scientific and Technical Literature of Latin America and the Caribbean and Virtual Health Library. A new classification of periodontal disease included tools for individual assessment of the patient and recognizing risk factors that might negatively interfere in response to treatment. The occurrence of metabolic lack of control in periodontal patients with type 2 diabetes mellitus is now considered a factor of great importance for the assessment of individual susceptibility to the progression of periodontitis. Diabetes is believed to promote a hyper inflammatory response to bacterial challenge by modifying the tissue response of periodontal tissues.

scholarly journals The Correlation between Periodontal Diseases and Chronological Age among Type 2 Diabetes Mellitus Patients attending at National Healthcare Network (NHN) Mirpur Centre, Dhaka, Bangladesh

2013 ◽  
Vol 3 (2) ◽  
pp. 74-69 ◽  
Author(s):  
Shaikh Zakir Mahmud ◽  
Sheikh Mohammad Alif ◽  
Monowar Ahmad Tarafder ◽  
Sarder Mahmud Hossain
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Periodontal Diseases ◽  
Chronological Age ◽  
Diabetic Patients ◽  
National Healthcare ◽  
Healthcare Network ◽  
The Relationship

Background: The relationship between diabetes and periodontal diseases has been studied extensively during the past 50 years. Type 2 diabetes occurs mainly in people aged over 40, although it is affecting a growing number of young people. Patients with uncontrolled diabetes have poor resistance to infection with effects in mouth cavity and elsewhere in the body and show an unusually high susceptibility to periodontal diseases and increased susceptibility to acute lateral periodontal abscesses. Objective: This descriptive type of cross-sectional study was conducted to find out the relationship between periodontal diseases and chronological age among type 2 diabetes mellitus patients attending at National Healthcare Network (NHN) Mirpur Centre, Dhaka. Materials and Methods: A total 120 type 2 diabetic patients attended at diabetic centre for routine checkup over a period of six months from August 2011 to January 2012 who fulfilled the eligibility criteria were selected consecutively. Pre-tested semi structured interviewer administered questionnaires were used to collect the information. Cross tabulations and associations were determined by using the chi-square test and simple linear regression from Statistical Package for the Social Sciences where applicable. Results: Chronological age of the patients was significantly associated with the manifestation of periodontal diseases (p=0.004). Moreover, age was useful as a predictor of periodontal diseases as the correlation coefficients showed statistically significant result (p=0.008). In addition, for each year increase of age of the patients there was 0.20% increase of occurrence of periodontal diseases. Conclusion: Periodontal diseases can adversely affect the metabolic control of diabetes. Conversely, treatment of periodontal disease and reduction of oral inflammation may have a positive effect on the diabetic condition, although evidence for this remains somewhat equivocal. Birdem Med J 2013; 3(2): 74-79 DOI: http://dx.doi.org/10.3329/birdem.v3i2.17209

The interaction of the dentist with an endocrinologist – a team approach in the treatment of inflammatory periodontal diseases in patients with type 2 diabetes mellitus (literature review)

2019 ◽  
Vol 24 (2) ◽  
pp. 140-144
Author(s):  
T. G. Petrova ◽  
N. B. Borodina ◽  
S. D. Rymar ◽  
O. D. Rymar
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Glycemic Control ◽  
Periodontal Disease ◽  
Periodontal Diseases ◽  
Epidemiological Studies ◽  
Team Approach ◽  
Therapeutic Implications

Relevance. Numerous epidemiological studies have found a high degree of association between DM and periodontal disease, and periodontal disease has even been proposed as a sixth complication of DM. It has also been demonstrated that this relationship is bidirectional, with periodontitis exerting an effect on DM. These fndings have diagnostic and therapeutic implications. Thus, the high prevalence of periodontal disease in DM indicates the need to evaluate glucose levels in periodontal patients. Conversely, intervention studies have demonstrated that the treatment of periodontal disease improves the glycemic control of DM patients. To alert health professionals about the risk that periodontitis represents for the onset or exacerbation of complications in individuals with type 2 diabetes mellitus (DM) and to emphasize that the mechanical treatment of periodontal disease and reestablishment of oral health are essential for the metabolic control of these patients.Materials and methods. A review of the literature on the topic of 30 sources from them 5 domestic and 25 foreign data.Some researchers demonstrate the Periodontal screening must be part of the overall clinical examination of patients with diabetes and, if diagnosed, periodontal disease must be treated appropriately to avoid or exacerbate diabetes complications besides improving glycemic control in these individuals.Results: In the postoperative period during the frst three days, patients of both groups had moderate soft tissue edema, slight flap hyperemia and palpation pain.Conclusions. Increased knowledge of dentists, endocrinologists and the public is required to improve early diagnosis of diabetes, adequate management, prevention and treatment of dental diseases in patients with DM.

Systematic Literature Review and Network Meta-analysis (NMA) of SGLT2i as Monotherapy for Type 2 Diabetes Mellitus (T2DM)

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1159-P
Author(s):  
GLENN M. DAVIES ◽  
ANN MARIE MCNEILL ◽  
ELIZA KRUGER ◽  
STACEY L. KOWAL ◽  
FLAVIA EJZYKOWICZ ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Literature Review ◽  
Systematic Literature Review ◽  
Meta Analysis

scholarly journals The Relationship between the Gut Microbiome and Metformin as a Key for Treating Type 2 Diabetes Mellitus

2021 ◽  
Vol 22 (7) ◽  
pp. 3566
Author(s):  
Chae Bin Lee ◽  
Soon Uk Chae ◽  
Seong Jun Jo ◽  
Ui Min Jerng ◽  
Soo Kyung Bae
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Glucose Metabolism ◽  
Gut Microbiome ◽  
Metabolic Disorders ◽  
Current Knowledge ◽  
Potential Target ◽  
The Relationship

Metformin is the first-line pharmacotherapy for treating type 2 diabetes mellitus (T2DM); however, its mechanism of modulating glucose metabolism is elusive. Recent advances have identified the gut as a potential target of metformin. As patients with metabolic disorders exhibit dysbiosis, the gut microbiome has garnered interest as a potential target for metabolic disease. Henceforth, studies have focused on unraveling the relationship of metabolic disorders with the human gut microbiome. According to various metagenome studies, gut dysbiosis is evident in T2DM patients. Besides this, alterations in the gut microbiome were also observed in the metformin-treated T2DM patients compared to the non-treated T2DM patients. Thus, several studies on rodents have suggested potential mechanisms interacting with the gut microbiome, including regulation of glucose metabolism, an increase in short-chain fatty acids, strengthening intestinal permeability against lipopolysaccharides, modulating the immune response, and interaction with bile acids. Furthermore, human studies have demonstrated evidence substantiating the hypotheses based on rodent studies. This review discusses the current knowledge of how metformin modulates T2DM with respect to the gut microbiome and discusses the prospect of harnessing this mechanism in treating T2DM.

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