Is Autologous Fat Grafting an Oncologically Safe Procedure following Breast Conserving Surgery for Breast Cancer? A Comprehensive Review

ABSTRACT Objective: to evaluate local and systemic recurrence of breast cancer in patients submitted to autologous fat grafting in the immediate reconstruction after conservative surgery for breast cancer. Methods: this is a historical cohort study comparing 167 patients submitted to conservative surgery without reconstruction (conservative surgery group) with 27 patients submitted to conservative treatment with immediate graft reconstruction, following the Coleman's technique (lipofilling group). All patients had invasive carcinoma and were operated by a single surgeon from 2004 to 2011. The postoperative follow-up time was 36 months. Results: the overall incidence of local recurrence was 2.4%. No patient in the lipofilling group had local recurrence during the study period. For systemic recurrence, the rates obtained were 3.7% (one patient) for the fat grafting group and 1.8% (three patients) for the conservative surgery group without reconstruction. Conclusion: there was no significant difference for local or systemic recurrence in the groups studied. Immediate autologous fat grafting appears to be a safe procedure.

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Surgical Outcome and Cosmetic Results of Autologous Fat Grafting After Breast Conserving Surgery and Radiotherapy for Breast Cancer: A Retrospective Cohort Study of 222 Fat Grafting Sessions in 109 Patients

Aesthetic Plastic Surgery ◽

10.1007/s00266-017-0946-4 ◽

2017 ◽

Vol 41 (6) ◽

pp. 1334-1341 ◽

Cited By ~ 10

Author(s):

Arjen A. van Turnhout ◽

Saskia Fuchs ◽

Kristel Lisabeth-Broné ◽

Eline J. C. Vriens-Nieuwenhuis ◽

Wouter B. van der Sluis

Keyword(s):

Breast Cancer ◽

Cohort Study ◽

Retrospective Cohort Study ◽

Surgical Outcome ◽

Retrospective Cohort ◽

Breast Conserving Surgery ◽

Fat Grafting ◽

Autologous Fat Grafting ◽

Autologous Fat ◽

Cosmetic Results

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Autologous fat grafting for breast reconstruction after breast cancer: a 12-year experience

Archives of Gynecology and Obstetrics ◽

10.1007/s00404-021-06241-1 ◽

2021 ◽

Author(s):

Sally Kempa ◽

Eva Brix ◽

Norbert Heine ◽

Vanessa Hösl ◽

Catharina Strauss ◽

...

Keyword(s):

Breast Cancer ◽

Tumor Recurrence ◽

Tumor Resection ◽

Distant Metastases ◽

Fat Grafting ◽

Breast Cancer Surgery ◽

Long Term Results ◽

Safe Procedure ◽

Autologous Fat Grafting ◽

Autologous Fat

Abstract Purpose The aim of our study was to examine the surgical outcome and complications (efficiency) as well as the incidence of locoregional recurrence and distant metastases (oncological safety) in patients who underwent autologous fat grafting (AFG) of the breast following breast cancer surgery. Methods In our monocentric cohort study, retrospective and prospective data were collected from all consecutive patients who underwent AFG after breast cancer between 2008 and 2020; a total of 93 patients met the inclusion criteria. Results Our long-term results showed no increase in tumor recurrence and distant metastases in the studied collective when compared to the available literature. We observed 1 local recurrence (1.1%), 2 distant metastases (2.2%), and 1 tumor-related death (1.1%). There was a high degree of patient satisfaction; 67.12% of patients reported adequate satisfaction with autologous fat grafting. Conclusion Currently, to our knowledge, this is the study with the longest follow-up time (mean 6.7 years after AFG and 11.5 years after tumor resection). The results of our clinical study will contribute to improve evidence in the broad field of AFG, adipose stem cell and tumor research. Consistent with our study, the literature review shows a clear tendency of clinical trial results with a low incidence rate of tumor recurrence and metastasis following the use of AFG. AFG seems to be a safe procedure also after breast cancer treatment.

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