Background:
Coronary artery bypass graft (CABG) is associated with oxidative stress and
tissue damage. Vitamin C, as an antioxidant agent, has an important role in attenuating the oxidative
stress damage and might have cardio-protective effects after CABG. We aimed to evaluate the probable
roles of vitamin C supplementation in cardiac biomarkers after CABG.
Methods::
In this randomized control trial, 122 patients undergoing CABG were randomly assigned
to the intervention (n=54) and control group (n=68) and received vitamin C (2 g intravenously) or
placebo, respectively. The surgical methods of the patients in the two groups were identical. The
primary efficacy endpoint of this trial is the difference in the levels of CK-MB, Troponin and Total
Antioxidant Capacity (TAC) were measured at study entry and 24 hrs after surgery between the two
groups.
Results::
The two groups were not significantly different in terms of basic variables. Within-group
comparison showed significant rises in the level of troponin (P < 0.001) and CK-MB (P < 0.001)
over time. However, between-group comparison showed no significant difference between the two
groups in terms of CK-MB (P=0.826) and troponin (P=0.821). As a whole, the correlation between
cardiac enzymes and surgical characteristic was not seen.
Conclusion::
The results showed that pretreatment with vitamin C could not reduce cardiac marker
following CABG. After the intervention, TAC did not differ between and within the intervention and
the control groups. Pretreatment with vitamin C as an antioxidant agent could not reduce ischemicreperfusion
resulting in CABG.
The efficacy of topical human amniotic membrane-mesenchymal stem cell-conditioned medium (hAMMSC-CM) and a mixture of topical hAMMSC-CM + vitamin C and hAMMSC-CM + vitamin E on chronic plantar ulcers in leprosy:a randomized control trial