Characterizing the DNA damage response in fibrosarcoma stem cells by in-situ cell tracking

2018 ◽  
Vol 95 (2) ◽  
pp. 99-106
Author(s):  
Qibin Fu ◽  
Jing Wang ◽  
Tuchen Huang
Keyword(s):  
Stem Cells ◽  
Dna Damage ◽  
Dna Damage Response ◽  
Cell Tracking ◽  
Damage Response

scholarly journals Characterizing the DNA damage response in putative stem cells of resected normal lung and matched NSCLC patient samples

2017 ◽  
Vol 28 ◽  
pp. ii4
Author(s):  
T.M. Marti ◽  
C.C. Tièche ◽  
R. Peng ◽  
S.R.R. Hall ◽  
L. Froment ◽  
...  
Keyword(s):  
Stem Cells ◽  
Dna Damage ◽  
Dna Damage Response ◽  
Nsclc Patient ◽  
Normal Lung ◽  
Damage Response

scholarly journals Cell cycle inertia underlies a bifurcation in cell fates after DNA damage

2021 ◽  
Vol 7 (3) ◽  
pp. eabe3882
Author(s):  
Jenny F. Nathans ◽  
James A. Cornwell ◽  
Marwa M. Afifi ◽  
Debasish Paul ◽  
Steven D. Cappell
Keyword(s):  
Dna Damage ◽  
Dna Damage Response ◽  
Cell Tracking ◽  
Time Lapse ◽  
S Phase ◽  
Cdk Inhibitor ◽  
Cyclin Dependent Kinase ◽  
Cell Fates ◽  
Damage Response ◽  
Time Lapse Imaging

The G1-S checkpoint is thought to prevent cells with damaged DNA from entering S phase and replicating their DNA and efficiently arrests cells at the G1-S transition. Here, using time-lapse imaging and single-cell tracking, we instead find that DNA damage leads to highly variable and divergent fate outcomes. Contrary to the textbook model that cells arrest at the G1-S transition, cells triggering the DNA damage checkpoint in G1 phase route back to quiescence, and this cellular rerouting can be initiated at any point in G1 phase. Furthermore, we find that most of the cells receiving damage in G1 phase actually fail to arrest and proceed through the G1-S transition due to persistent cyclin-dependent kinase (CDK) activity in the interval between DNA damage and induction of the CDK inhibitor p21. These observations necessitate a revised model of DNA damage response in G1 phase and indicate that cells have a G1 checkpoint.

scholarly journals Lack of DNA Damage Response at Low Radiation Doses in Adult Stem Cells Contributes to Organ Dysfunction

2018 ◽  
Vol 24 (24) ◽  
pp. 6583-6593 ◽  
Author(s):  
Peter W. Nagle ◽  
Nynke A. Hosper ◽  
Lara Barazzuol ◽  
Anne L. Jellema ◽  
Mirjam Baanstra ◽  
...  
Keyword(s):  
Stem Cells ◽  
Dna Damage ◽  
Organ Dysfunction ◽  
Dna Damage Response ◽  
Adult Stem Cells ◽  
Radiation Doses ◽  
Damage Response ◽  
Low Radiation Doses

In Situ Analysis of DNA Damage Response and Repair Using Laser Microirradiation

2007 ◽  
pp. 377-407 ◽  
Author(s):  
Jong‐Soo Kim ◽  
Jason T. Heale ◽  
Weihua Zeng ◽  
Xiangduo Kong ◽  
Tatiana B. Krasieva ◽  
...  
Keyword(s):  
Dna Damage ◽  
Dna Damage Response ◽  
In Situ Analysis ◽  
Damage Response ◽  
Laser Microirradiation

scholarly journals DNA Damage Response/Repair in Cancer Stem Cells — Potential vs. Controversies

10.5772/61355 ◽  
2015 ◽  
Author(s):  
Maria Louka ◽  
Effrossyni Boutou ◽  
Vasiliki Bakou ◽  
Vassiliki Pappa ◽  
Anastasios Georgoulis ◽  
...  
Keyword(s):  
Stem Cells ◽  
Dna Damage ◽  
Cancer Stem Cells ◽  
Dna Damage Response ◽  
Damage Response

scholarly journals Pluripotent Stem Cells and DNA Damage Response to Ionizing Radiations

2016 ◽  
Vol 186 (1) ◽  
pp. 17-26 ◽  
Author(s):  
Kalpana Mujoo ◽  
E. Brian Butler ◽  
Raj K. Pandita ◽  
Clayton R. Hunt ◽  
Tej K. Pandita
Keyword(s):  
Stem Cells ◽  
Dna Damage ◽  
Dna Damage Response ◽  
Pluripotent Stem Cells ◽  
Damage Response ◽  
Ionizing Radiations

Systems Biology Approach Identifies the Kinase Csnk1a1 as a Regulator of the DNA Damage Response in Embryonic Stem Cells

2013 ◽  
Vol 6 (259) ◽  
pp. ra5-ra5 ◽  
Author(s):  
J. Carreras Puigvert ◽  
L. von Stechow ◽  
R. Siddappa ◽  
A. Pines ◽  
M. Bahjat ◽  
...  
Keyword(s):  
Stem Cells ◽  
Dna Damage ◽  
Systems Biology ◽  
Embryonic Stem Cells ◽  
Dna Damage Response ◽  
Embryonic Stem ◽  
Damage Response

scholarly journals Distinct Regulatory Mechanisms and Functions for p53-Activated and p53-Repressed DNA Damage Response Genes in Embryonic Stem Cells

2012 ◽  
Vol 46 (1) ◽  
pp. 30-42 ◽  
Author(s):  
Mangmang Li ◽  
Yunlong He ◽  
Wendy Dubois ◽  
Xiaolin Wu ◽  
Jianxin Shi ◽  
...  
Keyword(s):  
Stem Cells ◽  
Dna Damage ◽  
Embryonic Stem Cells ◽  
Dna Damage Response ◽  
Embryonic Stem ◽  
Regulatory Mechanisms ◽  
Damage Response
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