How Black and Latino young men who have sex with men in the United States experience and engage with eligibility criteria and recruitment practices: implications for the sustainability of community-based research

2021 ◽  
pp. 1-11
Author(s):  
Morgan M. Philbin ◽  
Adrian Guta ◽  
Heather Wurtz ◽  
Elizabeth N. Kinnard ◽  
Ian Bradley-Perrin ◽  
...  
Keyword(s):  
United States ◽  
Young Men ◽  
The United States ◽  
Community Based ◽  
Eligibility Criteria ◽  
Community Based Research ◽  
Recruitment Practices ◽  
States Experience ◽  
Sex With Men ◽  
Black And Latino

scholarly journals Estimated Impact of Targeted Pre-Exposure Prophylaxis: Strategies for Men Who Have Sex with Men in the United States

2019 ◽  
Vol 16 (9) ◽  
pp. 1592 ◽  
Author(s):  
Richard A. Elion ◽  
Mina Kabiri ◽  
Kenneth H. Mayer ◽  
David A. Wohl ◽  
Joshua Cohen ◽  
...  
Keyword(s):  
United States ◽  
The United States ◽  
Black Msm ◽  
Number Needed To Treat ◽  
Latino Msm ◽  
Sex With Men ◽  
Young Black Msm ◽  
Exposure Prophylaxis ◽  
The Impact ◽  
Black And Latino

Pre-exposure prophylaxis (PrEP) effectively reduces human immunodeficiency virus (HIV) transmission. We aimed to estimate the impact of different PrEP prioritization strategies among Black and Latino men who have sex with men (MSM) in the United States, populations most disproportionately affected by HIV. We developed an agent-based simulation to model the HIV epidemic among MSM. Individuals were assigned an HIV incidence risk index (HIRI-MSM) based on their sexual behavior. Prioritization strategies included PrEP use for individuals with HIRI-MSM ≥10 among all MSM, all Black MSM, young (≤25 years) Black MSM, Latino MSM, and young Latino MSM. We estimated the number needed to treat (NNT) to prevent one HIV infection, reductions in prevalence and incidence, and subsequent infections in non-PrEP users avoided under these strategies over 5 years (2016–2020). Young Black MSM eligible for PrEP had the lowest NNT (NNT = 10) followed by all Black MSM (NNT = 33) and young Latino MSM (NNT = 35). All Latino MSM and all MSM had NNT values of 63 and 70, respectively. Secondary infection reduction with PrEP was the highest among young Latino MSM (53.2%) followed by young Black MSM (37.8%). Targeting all MSM had the greatest reduction in prevalence (14.7% versus 2.9%–3.9% in other strategies) and incidence (49.4% versus 9.4%–13.9% in other groups). Using data representative of the United States MSM population, we found that a strategy of universal PrEP use by MSM was most effective in reducing HIV prevalence and incidence of MSM. Targeted use of PrEP by Black and Latino MSM, however, especially those ≤25 years, had the greatest impact on HIV prevention.

scholarly journals A three-city comparison of drug use and drug use before sex among young men who have sex with men in the United States

2017 ◽  
Vol 30 (1) ◽  
pp. 82-101 ◽  
Author(s):  
Brian A. Feinstein ◽  
Raymond L. Moody ◽  
Steven A. John ◽  
Jeffrey T. Parsons ◽  
Brian Mustanski
Keyword(s):  
United States ◽  
Drug Use ◽  
Young Men ◽  
The United States ◽  
Sex With Men

scholarly journals Influence of Partner Type on Acceptability and Likelihood of Use of a Rectal Microbicide Among Young Men Who Have Sex With Men in the United States and Puerto Rico

2015 ◽  
Vol 53 (6) ◽  
pp. 633-641 ◽  
Author(s):  
Rebecca Giguere ◽  
Curtis Dolezal ◽  
José A. Bauermeister ◽  
Timothy Frasca ◽  
Juan Valladares ◽  
...  
Keyword(s):  
United States ◽  
Puerto Rico ◽  
Young Men ◽  
The United States ◽  
Partner Type ◽  
Sex With Men ◽  
Rectal Microbicide

scholarly journals Myocardial Infarction and Stroke Risk in Young Healthy Men Treated with Injectable Testosterone

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Robert S. Tan ◽  
Kelly R. Cook ◽  
William G. Reilly
Keyword(s):  
United States ◽  
Myocardial Infarction ◽  
Medical Records ◽  
Stroke Risk ◽  
Significant Risk ◽  
The United States ◽  
Community Based ◽  
Eligibility Criteria ◽  
Healthy Men ◽  
Younger Men

This study was conducted to examine the association between testosterone therapy and new myocardial infarction (MI) and stroke events in a series of patients treated at Low T Centers across the United States, consisting of mainly young (mean age = 46), otherwise, healthy men. Electronic medical records were queried between the years 2009 and 2014 to identify patients diagnosed with hypogonadism, MI, and stroke, as indicated by ICD-9 codes. The incidence of MI and stroke events was compared to community-based registries. 39,936 patients recruited from 40 Low T Centers across the United States were treated and 19,968 met eligibility criteria for receiving testosterone treatment. The incidence rate ratio (IRR) for MI in testosterone- (T-) treated versus nontreated patients was 0.14 (C.I. = 0.08 to 0.18,P<0.0001) whereas the IRR for stroke for T-treated versus nontreated patients was 0.11 (C.I. = 0.02 to 0.13,P<0.0001). There was no evidence of worsening preexisting MI or stroke in patients treated with testosterone. The experience in Low T Centers shows that, in an injectable testosterone patient registry, testosterone is generally safe for younger men who do not have significant risk factors. Of patients that developed MI with testosterone, there was no association with testosterone or hematocrit levels.

scholarly journals Title: Keep It Up! 3.0: Study Protocol for a Type III Hybrid Implementation-Effectiveness Cluster-Randomized Trial

2020 ◽  
Author(s):  
Brian Mustanski ◽  
Justin Patrick Jones ◽  
Kathryn Macapagal ◽  
Nanette Benbow ◽  
Dennis H. Li ◽  
...  
Keyword(s):  
Hiv Prevention ◽  
Randomized Trial ◽  
Young Men ◽  
Cluster Randomized Trial ◽  
The United States ◽  
Community Based ◽  
Direct To Consumer ◽  
Community Based Organization ◽  
Sex With Men ◽  
Cluster Randomized

Abstract BackgroundYoung men who have sex with men are disproportionately impacted by the HIV epidemic in the United States. Few rigorously tested HIV prevention interventions have been developed for young men who have sex with men; previous interventions have primarily focused on in-person programming, with high variability in fidelity. With nearly all young men who have sex with men going online daily, eHealth approaches to prevention may successfully bridge research and practice. Keep It Up! is an eHealth HIV Prevention program for young men who have sex with men. Previous research has demonstrated its effectiveness in reducing sexually transmitted infections and condomless anal sex and efficiency in delivering HIV prevention education. Aim 1 is to compare two strategies for implementing KIU—implementation in community-based organizations and a centralized direct-to-consumer recruitment arm. Aim 2 is to examine adoption characteristics which explain variability in implementation success. Our exploratory aim will develop recommendations and materials for sustainment of KIU after completion of the trial.MethodsThis is a Type III Hybrid Effectiveness-Implementation cluster randomized trial. Using estimates of young men who have sex with men per county in the United States, we identified 113 counties for our sample frame. Using an iterative process, we selected 66 counties to randomize 2:1 to our two strategies in Aim 1. The RE-AIM model for implementation science will be used to drive our outcome measurements in reach, effectiveness, implementation variability, and cost. Outcome measures will be collected from community-based organization staff participants, young men who have sex with men participants, and the technology provider. Our second aim will use mixed-methods research mapped onto the domains of the consolidated framework for implementation research. DiscussionThe trial has launched and is ongoing. This study is among the first to use a cluster randomized trial design in HIV implementation science. In comparing the community-based organization and direct to consumer models for recruitment and ongoing participant engagement, we are examining two strategies which have shown effectiveness in delivering health and technology interventions in the past, but with little base knowledge on their comparative advantages and disadvantages in implementation. The results of the trial will further understanding of the implementation of eHealth prevention interventions.Trial RegistrationNCT03896776, clinicaltrials.gov, 1 April 2019

scholarly journals Molecular analysis allows inference into HIV transmission among young men who have sex with men in the United States

AIDS ◽  
2015 ◽  
Vol 29 (18) ◽  
pp. 2517-2522 ◽  
Author(s):  
Y. Omar Whiteside ◽  
Ruiguang Song ◽  
Joel O. Wertheim ◽  
Alexandra M. Oster
Keyword(s):  
United States ◽  
Molecular Analysis ◽  
Hiv Transmission ◽  
Young Men ◽  
The United States ◽  
Sex With Men
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