Maltitol inhibits small intestinal glucose absorption and increases insulin mediated muscle glucose uptake ex vivo but not in normal and type 2 diabetic rats

2016 ◽  
Vol 68 (1) ◽  
pp. 73-81 ◽  
Author(s):  
Chika Ifeanyi Chukwuma ◽  
Mohammed Auwal Ibrahim ◽  
Md. Shahidul Islam
Keyword(s):  
Glucose Uptake ◽  
Ex Vivo ◽  
Glucose Absorption ◽  
Diabetic Rats ◽  
Intestinal Glucose Absorption ◽  
Small Intestinal ◽  
Type 2 Diabetic

scholarly journals Sorbitol increases muscle glucose uptake ex vivo and inhibits intestinal glucose absorption ex vivo and in normal and type 2 diabetic rats

2017 ◽  
Vol 42 (4) ◽  
pp. 377-383 ◽  
Author(s):  
Chika Ifeanyi Chukwuma ◽  
Md. Shahidul Islam
Keyword(s):  
Glycemic Control ◽  
Glucose Uptake ◽  
Ex Vivo ◽  
Glucose Absorption ◽  
Diabetic Rats ◽  
Dependent Manner ◽  
Intestinal Glucose Absorption ◽  
Type 2 Diabetic ◽  
Isolated Rat

Previous studies have suggested that sorbitol, a known polyol sweetener, possesses glycemic control potentials. However, the effect of sorbitol on intestinal glucose absorption and muscle glucose uptake still remains elusive. The present study investigated the effects of sorbitol on intestinal glucose absorption and muscle glucose uptake as possible anti-hyperglycemic or glycemic control potentials using ex vivo and in vivo experimental models. Sorbitol (2.5% to 20%) inhibited glucose absorption in isolated rat jejuna (IC50= 14.6% ± 4.6%) and increased glucose uptake in isolated rat psoas muscle with (GU50= 3.5% ± 1.6%) or without insulin (GU50= 7.0% ± 0.5%) in a concentration-dependent manner. Furthermore, sorbitol significantly delayed gastric emptying, accelerated digesta transit, inhibited intestinal glucose absorption, and reduced blood glucose increase in both normoglycemic and type 2 diabetic rats after 1 h of coingestion with glucose. Data of this study suggest that sorbitol exhibited anti-hyperglycemic potentials, possibly via increasing muscle glucose uptake ex vivo and reducing intestinal glucose absorption in normal and type 2 diabetic rats. Hence, sorbitol may be further investigated as a possible anti-hyperglycemic sweetener.

D-mannitol modulates glucose uptake ex vivo; suppresses intestinal glucose absorption in normal and type 2 diabetic rats

2019 ◽  
Vol 29 ◽  
pp. 30-36 ◽  
Author(s):  
Chika Ifeanyi Chukwuma ◽  
Motlalepula Gilbert Matsabisa ◽  
Ochuko L. Erukainure ◽  
Collins U. Ibeji ◽  
Md. Shahidul Islam
Keyword(s):  
Glucose Uptake ◽  
Ex Vivo ◽  
Glucose Absorption ◽  
Diabetic Rats ◽  
Intestinal Glucose Absorption ◽  
Type 2 Diabetic

Antidiabetic with antilipidemic and antioxidant effects of flindersine by enhanced glucose uptake through GLUT4 translocation and PPARγ agonism in type 2 diabetic rats

2021 ◽  
pp. 114883
Author(s):  
Santiagu Stephen Irudayaraj ◽  
Jacob Jincy ◽  
Christudas Sunil ◽  
Veeramuthu Duraipandiyan ◽  
Savarimuthu Ignacimuthu ◽  
...  
Keyword(s):  
Glucose Uptake ◽  
Diabetic Rats ◽  
Glut4 Translocation ◽  
Antioxidant Effects ◽  
Type 2 Diabetic

Metformin reduces the rate of small intestinal glucose absorption in type 2 diabetes

2016 ◽  
Vol 19 (2) ◽  
pp. 290-293 ◽  
Author(s):  
Tongzhi Wu ◽  
Cong Xie ◽  
Hang Wu ◽  
Karen L. Jones ◽  
Michael Horowitz ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Glucose Absorption ◽  
Intestinal Glucose Absorption ◽  
Small Intestinal

Boerhaavia diffusa inhibits key enzymes linked to type 2 diabetes in vitro and in silico; and modulates abdominal glucose absorption and muscle glucose uptake ex vivo

2018 ◽  
Vol 106 ◽  
pp. 1116-1125 ◽  
Author(s):  
Olajumoke A. Oyebode ◽  
Ochuko L. Erukainure ◽  
Chika I. Chukwuma ◽  
Collins U. Ibeji ◽  
Neil A. Koorbanally ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Glucose Uptake ◽  
In Silico ◽  
Ex Vivo ◽  
Glucose Absorption ◽  
Key Enzymes ◽  
Boerhaavia Diffusa

Increased PC-1 phosphodiesterase activity and inhibition of glucose uptake in adipocytes of type 2 diabetic rats

2006 ◽  
Vol 293 (1-2) ◽  
pp. 9-14 ◽  
Author(s):  
Karlene Barrett ◽  
Donovan McGrowder ◽  
Paul Brown ◽  
Dalip Ragoobirsingh
Keyword(s):  
Glucose Uptake ◽  
Diabetic Rats ◽  
Phosphodiesterase Activity ◽  
Type 2 Diabetic
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