Chemical Constituents and Chemotypes of Fresh Leaf Essential Oil of Wild Species Belonging to Sect. Camphor (Trew.) Meissn. in Southeastern China

2019 ◽  
Vol 22 (4) ◽  
pp. 1115-1122 ◽  
Author(s):  
Beihong Zhang ◽  
Chunsheng Wu ◽  
Zufei Xiao ◽  
Haiyan Zhang ◽  
Meng Cao ◽  
...  
2021 ◽  
Vol 14 (2) ◽  
pp. 064-076
Author(s):  
Enimeya Dressman Akuegbe ◽  
Idris Ajayi Oyemitan ◽  
Ifeoluwa Isaac Ogunlowo ◽  
Gugulethu Mathew Miya ◽  
Opeoluwa Oyehan Oyedeji ◽  
...  

Objectives: This study determined the chemical composition of essential oil obtained from fresh leaf of Plectranthus aegyptiacus, and evaluated it for novelty-induced behavioural (NIB) and determine its mechanism(s) of action in mice. Methods: The oil was hydro-distillated, and analyzed using gas chromatography-mass spectrometry. The effects of the oil (50, 100 and 150 mg/kg; i.p., n=6) on novelty-induced behavioural was assessed using open field test and head dipping on hole board. Probable mechanism(s) were evaluated using antagonists: flumazenil, naloxone and cyproheptadine at 2 mg/kg each, atropine and yohimbine at 5 mg/kg and 1 mg/kg respectively. Key Findings: The LD50 values obtained were 2154 and 490 mg/kg for oral and intraperitoneal routes respectively. The oil (50, 100 and150 mg/kg) significantly (p<0.05, 0.01 and 0.01) inhibited all NIB and head dips. Flumazenil significantly (p<0.05) reversed the effect of the oil on NIB; atropine, naloxone and cyproheptadine significantly (p<0.01, 0.01 and 0.001) potentiated inhibitory effect on NIB respectively, while yohimbine showed no significantly effect. The analyzed oil showed 61 compounds, and the major compounds were carvacrol, germacrene-D, p-cymene and [1,1'-Bicyclopentyl]-2,2'-diol. Conclusions: The study concluded that the oil possessed central nervous system depressant activity, which could be mediated mainly through augmentation of GABAergic neurotransmission, while cholinergic-(muscarinic), adrenergic and serotonergic pathways may be involved.


2016 ◽  
Vol 19 (6) ◽  
pp. 1527-1531 ◽  
Author(s):  
Sudipta Jena ◽  
Asit Ray ◽  
Ambika Sahoo ◽  
Basudeba Kar ◽  
Pratap Chandra Panda ◽  
...  

2016 ◽  
Vol 13 (4) ◽  
pp. 1-7 ◽  
Author(s):  
Samuel Okhale ◽  
Chukkol Buba ◽  
Peters Oladosu ◽  
Henry Egharevba ◽  
Grace Ugbabe ◽  
...  

2010 ◽  
Vol 50 (S1) ◽  
pp. 70-73 ◽  
Author(s):  
A. Senthil Kumar ◽  
V. Venkatesalu ◽  
K. Kannathasan ◽  
M. Chandrasekaran

2008 ◽  
Vol 3 (9) ◽  
pp. 1934578X0800300
Author(s):  
Adebayo A. Gbolade ◽  
Vânia Tira-Picos ◽  
J.M.F. Nogueira

The essential oil from Tithonia rotundifolia leaf growing wild in Osun State, Nigeria obtained by hydro-distillation has been characterised for the first time by combined GC and GC-MS analyses. Forty-six components representing 93.8% of the total oil have been fully identified. The oil is characterised largely by sesquiterpene hydrocarbons (78.1%), represented chiefly by germacrene D (33%) and β-caryophyllene (25.8%). The less important classes of components are monoterpene hydrocarbons (5.1%), oxygenated monoterpenes (0.3%), oxygenated sesquiterpenes (3.1%) and non-terpenes (7.2%).


INDIAN DRUGS ◽  
2018 ◽  
Vol 55 (06) ◽  
pp. 14-20
Author(s):  
S Sultana ◽  
◽  
M. Ali ◽  
S. R Mir ◽  

Piper betle L. (Piperaceae) is used in traditional medicinal diseases. Our study was planned to isolate chemical constituents from the leaves of P. betle variety desi and to characterized their structures. Phytochemical investigation of the methanolic extract of the leaves of P. betle variety desi led to isolate n-nonyl benzene (1-phenylnonane, 1), 4′-phenyl butanoxy n-hexanoate (4′-phenyl butanoxy caproate, 2), caffeic acid (3),1′-phenoloxy 5′α-hydroxyltetradecane (4) and 5-prop-2a-enyl-4,4′-(2′′α-arachidyloxy-3′′α-hydroxypropyl)-bispyrocatechol (1′′, 2′′-dihydro-2′′α-arachidyloxy-3′′α-hydroxybischavicol, 5). The structures of these phytoconstituents, isolated from this variety of P. betle for the first time, were established by spectroscopic methods and chemical constituents. The leaf essential oil was characterized by high percentage of farnesol (41.13%), acetyl eugenol (26.40%), valencene (6.34%), α - amorphene (3.43%), γ - cadinene (3.56%), isovanillin (2.27%), eugenol (1.21%), cadina-1,4-dione (1.77%) and α - bisabolene (1.15%).


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