Sex-dependent role of vesicular glutamate transporter 3 in stress-regulation and related anxiety phenotype during the early postnatal period

Stress ◽  
2016 ◽  
Vol 19 (4) ◽  
pp. 434-438 ◽  
Author(s):  
Diána Balázsfi ◽  
Lívia Farkas ◽  
Péter Csikota ◽  
Anna Fodor ◽  
Sándor Zsebők ◽  
...  
Keyword(s):  
Glutamate Transporter ◽  
Postnatal Period ◽  
Early Postnatal Period ◽  
Vesicular Glutamate Transporter ◽  
Stress Regulation

scholarly journals Axonal Segregation and Role of the Vesicular Glutamate Transporter VGLUT3 in Serotonin Neurons

2016 ◽  
Vol 10 ◽  
Author(s):  
Aurore N. Voisin ◽  
Ouissame Mnie-Filali ◽  
Nicolas Giguère ◽  
Guillaume M. Fortin ◽  
Erika Vigneault ◽  
...  
Keyword(s):  
Glutamate Transporter ◽  
Vesicular Glutamate Transporter ◽  
Serotonin Neurons

Role of the atypical vesicular glutamate transporter VGLUT3 in l-DOPA-induced dyskinesia

2016 ◽  
Vol 87 ◽  
pp. 69-79 ◽  
Author(s):  
Giuseppe Gangarossa ◽  
Monica Guzman ◽  
Vania F. Prado ◽  
Marco A.M. Prado ◽  
Stephanie Daumas ◽  
...  
Keyword(s):  
Glutamate Transporter ◽  
Vesicular Glutamate Transporter

scholarly journals MAPKs Are Highly Abundant but Do Not Contribute to α1-Adrenergic Contraction of Rat Saphenous Arteries in the Early Postnatal Period

2021 ◽  
Vol 22 (11) ◽  
pp. 6037
Author(s):  
Dina K. Gaynullina ◽  
Tatiana V. Kudryashova ◽  
Alexander V. Vorotnikov ◽  
Rudolf Schubert ◽  
Olga S. Tarasova
Keyword(s):  
P38 Mapk ◽  
Postnatal Period ◽  
Early Postnatal Period ◽  
Adult Rats ◽  
Mapk Activity ◽  
Phosphorylation Level ◽  
Adrenoceptor Agonist ◽  
Old Rats ◽  
Saphenous Artery

Previously, the abundance of p42/44 and p38 MAPK proteins had been shown to be higher in arteries of 1- to 2-week-old compared to 2- to 3-month-old rats. However, the role of MAPKs in vascular tone regulation in early ontogenesis remains largely unexplored. We tested the hypothesis that the contribution of p42/44 and p38 MAPKs to the contraction of peripheral arteries is higher in the early postnatal period compared to adulthood. Saphenous arteries of 1- to 2-week-old and 2- to 3-month-old rats were studied using wire myography and western blotting. The α1-adrenoceptor agonist methoxamine did not increase the phosphorylation level of p38 MAPK in either 1- to 2-week-old or 2- to 3-month-old rats. Accordingly, inhibition of p38 MAPK did not affect arterial contraction to methoxamine in either age group. Methoxamine increased the phosphorylation level of p42/44 MAPKs in arteries of 2- to 3-month-old and of p44 MAPK in 1- to 2-week-old rats. Inhibition of p42/44 MAPKs reduced methoxamine-induced contractions in arteries of 2- to 3-month-old, but not 1- to 2-week-old rats. Thus, despite a high abundance in arterial tissue, p38 and p42/44 MAPKs do not regulate contraction of the saphenous artery in the early postnatal period. However, p42/44 MAPK activity contributes to arterial contractions in adult rats.

scholarly journals Elimination of Glutamatergic Transmission From Hb9 Interneurons Does Not Impact Treadmill Locomotion

2021 ◽  
Author(s):  
Lina M Koronfel ◽  
Kevin C Kanning ◽  
Angelita Alcos ◽  
Christopher E Henderson ◽  
Robert M Brownstone
Keyword(s):  
Motor Neurons ◽  
Neural Circuits ◽  
Glutamate Transporter ◽  
Homeobox Gene ◽  
Vesicular Glutamate Transporter ◽  
Glutamatergic Neurotransmission ◽  
Glutamatergic Transmission ◽  
Glutamatergic Neurons ◽  
Treadmill Locomotion

Abstract The spinal cord contains neural circuits that can produce the rhythm and pattern of locomotor activity. It has previously been postulated that a rhythmogenic population of glutamatergic neurons, termed Hb9 interneurons, contributes to this rhythmogenesis. The homeobox gene, Hb9, is expressed in these interneurons as well as motor neurons. We developed a mouse line in which cre recombinase activity is inducible in neurons expressing Hb9. We then used this line to eliminate vesicular glutamate transporter 2 from Hb9 interneurons, and found that there were no deficits in treadmill locomotion. We conclude that glutamatergic neurotransmission by Hb9 interneurons is not required for locomotor rhythmogenesis. The role of these neurons in neural circuits remains elusive.

scholarly journals Elimination of glutamatergic transmission from Hb9 interneurons does not impact treadmill locomotion

2021 ◽  
Author(s):  
Lina M. Koronfel ◽  
Kevin C. Kanning ◽  
Angelita Alcos ◽  
Christopher E. Henderson ◽  
Robert M. Brownstone
Keyword(s):  
Motor Neurons ◽  
Neural Circuits ◽  
Glutamate Transporter ◽  
Homeobox Gene ◽  
Vesicular Glutamate Transporter ◽  
Glutamatergic Neurotransmission ◽  
Glutamatergic Transmission ◽  
Glutamatergic Neurons ◽  
Treadmill Locomotion

ABSTRACTThe spinal cord contains neural circuits that can produce the rhythm and pattern of locomotor activity. It has previously been postulated that a rhythmogenic population of glutamatergic neurons, termed Hb9 interneurons, contributes to this rhythmogenesis. The homeobox gene, Hb9, is expressed in these interneurons as well as motor neurons. We developed a mouse line in which cre recombinase activity is inducible in neurons expressing Hb9. We then used this line to eliminate vesicular glutamate transporter 2 from Hb9 interneurons, and found that there were no deficits in treadmill locomotion. We conclude that glutamatergic neurotransmission by Hb9 interneurons is not required for locomotor rhythmogenesis. The role of these neurons in neural circuits remains elusive.

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