Role of GABAB Receptor Agonist Baclofen in Acute Pain Modulation during the Early Postnatal Period

Pharmacology ◽  
2009 ◽  
Vol 84 (2) ◽  
pp. 104-110 ◽  
Author(s):  
Miloslav Franek ◽  
Simon Vaculin
Keyword(s):  
Acute Pain ◽  
Receptor Agonist ◽  
Postnatal Period ◽  
Pain Modulation ◽  
Early Postnatal Period

Sex-dependent role of vesicular glutamate transporter 3 in stress-regulation and related anxiety phenotype during the early postnatal period

Stress ◽  
2016 ◽  
Vol 19 (4) ◽  
pp. 434-438 ◽  
Author(s):  
Diána Balázsfi ◽  
Lívia Farkas ◽  
Péter Csikota ◽  
Anna Fodor ◽  
Sándor Zsebők ◽  
...  
Keyword(s):  
Glutamate Transporter ◽  
Postnatal Period ◽  
Early Postnatal Period ◽  
Vesicular Glutamate Transporter ◽  
Stress Regulation

F109 THE ROLE OF BETA 1 AND BETA 2 ADRENORECEPTOR IN ACUTE PAIN MODULATION

2011 ◽  
Vol 5 (S1) ◽  
pp. 105-106
Author(s):  
P. Lamothe Molina ◽  
A. Melo-Carrillo ◽  
A. Castillo Tovar ◽  
A. Lopez-Avila
Keyword(s):  
Acute Pain ◽  
Pain Modulation ◽  
Beta 2

scholarly journals MAPKs Are Highly Abundant but Do Not Contribute to α1-Adrenergic Contraction of Rat Saphenous Arteries in the Early Postnatal Period

2021 ◽  
Vol 22 (11) ◽  
pp. 6037
Author(s):  
Dina K. Gaynullina ◽  
Tatiana V. Kudryashova ◽  
Alexander V. Vorotnikov ◽  
Rudolf Schubert ◽  
Olga S. Tarasova
Keyword(s):  
P38 Mapk ◽  
Postnatal Period ◽  
Early Postnatal Period ◽  
Adult Rats ◽  
Mapk Activity ◽  
Phosphorylation Level ◽  
Adrenoceptor Agonist ◽  
Old Rats ◽  
Saphenous Artery

Previously, the abundance of p42/44 and p38 MAPK proteins had been shown to be higher in arteries of 1- to 2-week-old compared to 2- to 3-month-old rats. However, the role of MAPKs in vascular tone regulation in early ontogenesis remains largely unexplored. We tested the hypothesis that the contribution of p42/44 and p38 MAPKs to the contraction of peripheral arteries is higher in the early postnatal period compared to adulthood. Saphenous arteries of 1- to 2-week-old and 2- to 3-month-old rats were studied using wire myography and western blotting. The α1-adrenoceptor agonist methoxamine did not increase the phosphorylation level of p38 MAPK in either 1- to 2-week-old or 2- to 3-month-old rats. Accordingly, inhibition of p38 MAPK did not affect arterial contraction to methoxamine in either age group. Methoxamine increased the phosphorylation level of p42/44 MAPKs in arteries of 2- to 3-month-old and of p44 MAPK in 1- to 2-week-old rats. Inhibition of p42/44 MAPKs reduced methoxamine-induced contractions in arteries of 2- to 3-month-old, but not 1- to 2-week-old rats. Thus, despite a high abundance in arterial tissue, p38 and p42/44 MAPKs do not regulate contraction of the saphenous artery in the early postnatal period. However, p42/44 MAPK activity contributes to arterial contractions in adult rats.

scholarly journals The early postnatal period, mini-puberty, provides a window on the role of testosterone in human neurobehavioural development

2016 ◽  
Vol 38 ◽  
pp. 69-73 ◽  
Author(s):  
Melissa Hines ◽  
Debra Spencer ◽  
Karson TF Kung ◽  
Wendy V Browne ◽  
Mihaela Constantinescu ◽  
...  
Keyword(s):  
Postnatal Period ◽  
Early Postnatal Period

scholarly journals Role of brown adipose tissue in body temperature control during the early postnatal period in Syrian hamsters and mice

2019 ◽  
Vol 81 (10) ◽  
pp. 1461-1467 ◽  
Author(s):  
Ayumi TSUBOTA ◽  
Yuko OKAMATSU-OGURA ◽  
Jussiaea Valente BARIUAN ◽  
Junnosuke MAE ◽  
Shinya MATSUOKA ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Body Temperature ◽  
Brown Adipose Tissue ◽  
Temperature Control ◽  
Postnatal Period ◽  
Early Postnatal Period ◽  
Syrian Hamsters ◽  
Brown Adipose

scholarly journals Thyroid hormone insufficiency alters the expression of psychiatric disorder-related molecules in the hypothyroid mouse brain during the early postnatal period

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Katsuya Uchida ◽  
Kentaro Hasuoka ◽  
Toshimitsu Fuse ◽  
Kenichi Kobayashi ◽  
Takahiro Moriya ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Critical Period ◽  
Neuronal Development ◽  
Perinatal Period ◽  
Postnatal Period ◽  
Early Postnatal Period ◽  
Cortical Layers ◽  
Neuronal Nuclei ◽  
Antithyroid Agents

AbstractThe functional role of thyroid hormone (TH) in the cortex and hippocampus of mouse during neuronal development was investigated in this study. TH insufficiency showed a decrease in the expression of parvalbumin (PV) in the cortex and hippocampus of pups at postnatal day (PD) 14, while treatment with thyroxine from PD 0 to PD 14 ameliorated the PV loss. On the other hand, treatment with antithyroid agents in adulthood did not result in a decrease in the expression of PV in these areas. These results indicate the existence of a critical period of TH action during the early postnatal period. A decrease in MeCP2-positive neuronal nuclei was also observed in the cortical layers II–IV of the cerebral cortex. The brains were then stained with CUX1, a marker for cortical layers II–IV. In comparison with normal mice, CUX1 signals were decreased in the somatosensory cortex of the hypothyroid mice, and the total thickness of cortical layers II–IV of the mice was lower than that of normal mice. These results suggest that TH insufficiency during the perinatal period strongly and broadly affects neuronal development.

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